Task-specific changes in motor evoked potentials of lower limb muscles after different training interventions

Beck, Sandra; Taube, Wolfgang; Grüber, Markus; Amtage, Florian; Gollhofer, Albert; Schubert, Martin

doi:10.1016/j.brainres.2007.08.048

Cited by 145 publications

(123 citation statements)

References 45 publications

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“…Besides cross-sectional evidence, M1 and its processes have been linked to serial improvements in muscle strength as well. In young adults, corticospinal output and excitability increase (Beck et al 2007;Griffin and Cafarelli 2007;Lee et al 2009;Weier et al 2012), and shortinterval intracortical inhibition lowers (Goodwill et al 2012;Weier et al 2012). Gains in strength may also implicate interhemispheric interactions because unilateral training is shown to influence processes in M1 ipsilateral to the trained limb (Goodwill et al 2012).…”

mentioning

confidence: 99%

“…Across older and younger participants, using TMS, we examined the representation of biceps brachii, a key elbow flexor. We examined its excitability at corticospinal, intracortical and interhemispheric levels because these mechanisms interact to define motor output (Chen 2004;Daskalakis et al 2002;Udupa et al 2010) and are shown to alter with aging (Hinder et al 2010;Kossev et al 2002;Marneweck et al 2011;McGinley et al 2010;Oliviero et al 2006;Peinemann et al 2001;Pitcher et al 2003;Sale and Semmler 2005;Talelli et al 2008b) and with gains in strength in the young (Beck et al 2007;Goodwill et al 2012;Griffin and Cafarelli 2007;Kidgell and Pearce 2010;Lee et al 2009;Weier et al 2012). Our methods are unconventional because age-related adaptations have almost invariably been defined in terms of dexterity using study of distal hand/wrist muscles (Marneweck et al 2011;McGinley et al 2010;Peinemann et al 2001;Pitcher et al 2003;Sale and Semmler 2005;Talelli et al 2008b).…”

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confidence: 99%

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Neurophysiological correlates of aging-related muscle weakness

Plow

Cunningham

Bonnett

et al. 2013

Journal of Neurophysiology

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Muscle weakness associated with aging implicates central neural degeneration. However, role of the primary motor cortex (M1) is poorly understood, despite evidence that gains in strength in younger adults are associated with its adaptations. We investigated whether weakness of biceps brachii in aging analogously relates to processes in M1. We enrolled 20 young (22.6 Ϯ 0.87 yr) and 28 old (74.79 Ϯ 1.37 yr) right-handed participants. Using transcranial magnetic stimulation, representation of biceps in M1 was identified. We examined the effect of age and sex on strength of left elbow flexion, voluntary activation of biceps, corticospinal excitability and output, and short-interval intracortical and interhemispheric inhibition. Interhemispheric inhibition was significantly exaggerated in the old (P ϭ 0.047), while strength tended to be lower (P ϭ 0.075). Overall, women were weaker (P Ͻ 0.001). Processes of M1 related to strength or voluntary activation of biceps, but only in older adults. Corticospinal excitability was lower in weaker individuals (r ϭ 0.38), and corticospinal output, intracortical inhibition and interhemispheric inhibition were reduced too in individuals who poorly activated biceps (r ϭ 0.43, 0.54 and 0.38). Lower intracortical inhibition may reflect compensation for reduced corticospinal excitability, allowing weaker older adults to spread activity in M1 to recruit synergists and attempt to sustain motor output. Exaggerated interhemispheric inhibition, however, conflicts with previous evidence, potentially related to greater callosal damage in our older sample, our choice of proximal vs. distal muscle and differing influence of measurement of inhibition in rest vs. active states of muscle. Overall, age-specific relation of M1 to strength and muscle activation emphasizes that its adaptations only emerge when necessitated, as in a weakening neuromuscular system in aging.

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confidence: 99%

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confidence: 99%

Neurophysiological correlates of aging-related muscle weakness

Plow

Cunningham

Bonnett

et al. 2013

Journal of Neurophysiology

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“…Especially in this research field, more research, better interdisciplinary and international collaborations as well as better education, are necessary to achieve the common goal to improve patients' clinical outcome as well as quality of life. [97][98][99][100]117,127,128,131,133,151 (modified from . …”

Section: Resultsmentioning

confidence: 99%

“…This can be achieved either via the choice of exercises, following the exercise principals: from easy to complex exercises e.g, from bipedal to monopedal exercises, gradually reducing the supporting surface, making it more and more instable or adding additional perturbations, irritations, tools (e.g. [97][98][99][100]117,127,128,131,133,151 (modified from .…”

Section: Sensorimotor Trainingmentioning

confidence: 99%

Exercise, concomitant to therapy, has a positive influence on therapy-induced side-effects in patients with haematological malignancies

Streckmann¹

2014

JOSHA

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JOSHA is a service that helps scholars, researchers, and students descover, use, and build upon a wide range of content Exercise, concomitant to therapy, has a positive influence on therapyinduced side-effects in patients with haematological malignancies discussions. Special thanks also goes to Katja Zirlik, Christiane Guderian, Barbara Nuber and the team on ward Romberg for the many enlighting lunch breaks and skiing trips that were incredibly valuable during rougher times of work, but also for their academic support and advice. Furthermore, I am very grateful to the team of sport therapists, sport students and physiotherapists that worked on the training cite for oncological patients and supported me in the implementation of the exercise intervention. Especially to Svenja Simon-Hein, from whom I was able to learn a great deal. I also greatly appreciate the support of the research assistants, the recruiting doctors, the nurses, technical lab assistants as well as the IT support in the University Hospital of Freiburg as well as my colleagues in the University of Freiburg.A special thank you goes to all the patients who participated in the study and therefore made an essential contribution to this work as well as future research. ABSTRACTExercise interventions as a supportive measure in cancer therapy are becoming more and more relevant. With cancer therapy becoming more complex and effective, higher survival rates as well as longer life-spans are being achieved. Consequently, patients' quality of life is becoming increasingly important and the management of therapy-related side-effects therefore essential. An increasing amount of studies are demonstrating, that the previously propagated rest and immobility during cancer therapy is not only counterproductive but that exercise interventions hold enormous potential regarding the management of sideeffects in supportive cancer care and should therefore be taken more seriously.Especially haemato-oncological patients have to cope with many debilitating side-effects due to the disease itself, the long and complex medical therapy as well as the associated immobility. The symptoms cause physiological, psychological and social restraints, leading to acute as well as lasting reductions in patients' quality of life. Poor health and severe side-effects such as chemotherapy-induced peripheral neuropathy (CIPN) are highly relevant, as they can cause dose reductions, disruptions or discontinuation of medical therapy, consequently impacting the clinical outcome.Although the positive effects of exercise interventions are rather well documented in entities such as breast cancer, the amount of research in haematological patients, especially concomitant to therapy, is still relatively low. For instance only one previous randomized, controlled trial (RCT) 1 has evaluated lymphoma patients. Furthermore, the potential role of exercise regarding CIPN has never been investigated previously, although it is highly prevalent in haemato-oncological patients. Previous studies on patients wit...

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“…Regarding the facilitatory neuromodulative effects of muscle training, it could be demonstrated in several studies that even short-term muscle training increases the excitability in supraspinal and also in spinal centres [17,18]. This is one of the first mechanisms together with adaptations in motor unit recruitment which is involved in the very early changes after starting muscle training [18].…”

Section: Discussionmentioning

confidence: 99%

The facilitatory effect of duloxetine combined with pelvic floor muscle training on the excitability of urethral sphincter motor neurons

et al. 2009

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The facilitatory effect of duloxetine combined with pelvic floor muscle training on the excitability of urethral sphincter motor neurons The facilitatory effect of duloxetine combined with pelvic floor muscle training on the excitability of urethral sphincter motor neurons Abstract INTRODUCTION AND HYPOTHESIS: Aim of this study was to investigate the excitability of sphincter motor neurons under the influence of pelvic floor muscle training (PFMT) and duloxetine. Due to their mechanisms of action, there might be a synergistic effect of duloxetine and PFMT in regard to the facilitation of spinal reflexes controlling urethral sphincter contractions and hence continence. METHODS: In ten healthy female subjects, clitoral electric stimulation (CES) and transcranial magnetic stimulation (TMS) were used to determine individual motor thresholds for external urethral sphincter (EUS) contractions before and after PFMT, duloxetine, and PFMT + duloxetine. RESULTS: PFMT and duloxetine alone significantly decreased the motor thresholds for EUS contractions during CES and TMS. However, the combined treatment reduced the motor threshold for EUS contractions significantly stronger compared to PFMT or duloxetine alone. CONCLUSIONS: The results are suggestive for a synergistic facilitatory effect of PFMT and duloxetine on sphincter motor neuron activation.The facilitatory effect of duloxetine combined with pelvic floor muscle training on the excitability of urethral sphincter motor neurons.

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Task-specific changes in motor evoked potentials of lower limb muscles after different training interventions

Cited by 145 publications

References 45 publications

Neurophysiological correlates of aging-related muscle weakness

Neurophysiological correlates of aging-related muscle weakness

Exercise, concomitant to therapy, has a positive influence on therapy-induced side-effects in patients with haematological malignancies

The facilitatory effect of duloxetine combined with pelvic floor muscle training on the excitability of urethral sphincter motor neurons

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