Taste alterations and cancer treatment

Oort, Sophie van; Kramer, Ellen; Groot, Jan-Willem de; Visser, Otto

doi:10.1097/spc.0000000000000346

Cited by 35 publications

(24 citation statements)

References 22 publications

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“…It is seen in about 70% of breast cancer patients (Bernhardson et al, 2008). Taste alterations due to chemotherapy may be attributed to various causes, such as neurotransmission blockage, decreased salivation, or psychological effects (McLaughlin and Mahon, 2012;Sakaguchi et al, 2013;Sözeri and Kutlutürkan, 2015;van Oort et al, 2018). The treatment for coping with taste alterations include zinc intake (Murtaza et al, 2017), use of herbal medicines (Ben Arye et al, 2018), and gargling and dietary changes (Speck et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of a self-monitoring intervention in breast cancer patients suffering from taste alterations induced by chemotherapy: A randomized, parallel-group controlled trial

Kinjo

Kanda

Fujimoto

2021

European Journal of Oncology Nursing

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This study evaluates the effect of a self-monitoring intervention on taste alterations in breast cancer patients undergoing outpatient chemotherapy. Methods: The study was a randomized controlled trial. Thirty-four participants were divided into two groups: a self-monitoring (SMG) group (n = 17) and a control group (CG) (n = 17). A conceptual framework was developed with reference to the components of self-management, cognitive behavioral therapy, and the concepts of self-monitoring. Interventions were based on this framework. SMGs recorded their taste symptoms as homework and worked with the researcher to set goals and provide feedback four times every three weeks. In the feedback, the researcher actively listened to the SMG about their feelings and coping strategies during the taste changes, and gave approval and praise for these. The implementation period was 9 weeks for each participant; the CG was provided with conventional nursing support. The intervention was evaluated by comparing the items of symptom improvement, quality of life (QOL), and self-efficacy between the groups before and after the start of the intervention using a scale score. Scale scores were also compared for recognition of taste changes, concerns during treatment, distress, and impacts on each treatment day. Results: SMG had significantly lower scores than CG for perceived change in taste (p = 0.009), and there was an interaction with CG (p = 0.008). SMG had also significantly lower scores than CG in concern during treatment (p = 0.015). Conclusion:This study showed that a self-monitoring intervention reduced negative cognition of taste alterations and reduced discomfort. The results suggest that the self-monitoring intervention is effective nursing support for chemotherapy-induced taste alterations.

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Section: Introductionmentioning

confidence: 99%

Effects of a self-monitoring intervention in breast cancer patients suffering from taste alterations induced by chemotherapy: A randomized, parallel-group controlled trial

Kinjo

Kanda

Fujimoto

2021

European Journal of Oncology Nursing

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“…In patients treated with chemotherapy, the threshold to detect sweet and salty tastes is usually described to be higher, while our patients reported a lower detection for sweet and a varying higher and lower detection for salt [23]. It should be noted that our study used subjective data and the detection could therefore be misperceived by the patients.…”

Section: Discussionmentioning

confidence: 53%

“…Several hypotheses on the potential mechanisms exist, but it is not understood why differences in the perception of taste and smell occur between patients using TKIs. A diminished amount of saliva and also oral mucositis can occur in both patients using chemotherapy and TKIs, which could lead to diminished taste and smell [10,23,25]. A mechanism that may explain specific changes in sweet, salt, bitter, and sour taste is the inhibitory effect of imatinib, sunitinib, and regorafenib on β-catenin.…”

Section: Discussionmentioning

confidence: 99%

Taste, smell and mouthfeel disturbances in patients with gastrointestinal stromal tumors treated with tyrosine-kinase inhibitors

Elst

IJzerman

Mathijssen

et al. 2021

Support Care Cancer

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Context Taste, smell, and mouthfeel disturbances are underrated and underreported, but important side effects of anti-cancer medication. These symptoms are associated with a lower quality of life (QoL). The prevalence and the impact of taste, smell, and mouthfeel disturbances on daily life in patients with a gastrointestinal stromal tumor (GIST) are largely unknown. Objectives This exploratory study assessed the prevalence and type of taste, smell, and mouthfeel disturbances and their impact on daily life and QoL in patients with a GIST treated with a tyrosine-kinase inhibitor (TKI). Methods Patients currently treated with TKIs for GIST completed a standardized questionnaire. The questionnaire addressed changes in taste, smell, and mouthfeel and, if changes occurred, impact on daily life and QoL. Statistics are descriptive. Results A total of 65 GIST patients on TKI treatment completed the questionnaire. Of these patients, 79%, 12%, and 9% currently used imatinib, sunitinib, and regorafenib respectively. Taste, smell, and mouthfeel disturbances were reported by 25 (38%), 15 (23%), and 36 (55%) patients respectively. Salty and sweet tastes were mostly affected, respectively in 14 and 13 patients. A dry mouth was experienced by 29 (45%) patients. Taste disturbances were more often reported to have impact on daily life and QoL (80% and 60%) than smell (47% and 31%) and mouthfeel disturbances (47% and 30%). Conclusion Taste, smell, and mouthfeel disturbances are frequent side effects of TKIs in GIST patients. Daily life and QoL are affected in a considerable number of those patients. Trial registration ClinicalTrials.gov Identifier: NL7827 (2019-06-25).

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“…It can decrease the appetite leading to reduced oral intake and weight loss. Zinc supplements have shown to be useful to improve the dysgeusia in a few studies (17)(18)(19).…”

Section: Dental Care For Hnc Patientsmentioning

confidence: 99%

The Multidisciplinary Team (MDT) Approach and Quality of Care

et al. 2020

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The core function of a multidisciplinary team (MDT) is to bring together a group of healthcare professionals from different fields in order to determine patients' treatment plan. Most of head and neck cancer (HNC) units are currently led by MDTs that at least include ENT and maxillofacial surgeons, radiation and medical oncologists. HNC often compromise relevant structures of the upper aerodigestive tract involving functions such as speech, swallowing and breathing, among others. The impairment of these functions can significantly impact patients' quality of life and psychosocial status, and highlights the crucial role of specialized nurses, dietitians, psycho-oncologists, social workers, and onco-geriatricians, among others. Hence, these professionals should be integrated in HNC MDTs. In addition, involving translational research teams should also be considered, as it will help reducing the existing gap between basic research and the daily clinical practice. The aim of this comprehensive review is to assess the role of the different supportive disciplines integrated in an MDT and how they help providing a better care to HNC patients during diagnosis, treatment and follow up.

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Taste alterations and cancer treatment

Abstract: Taste is a combination of different sensations: smell, texture, temperature and saliva play an important role in determining the overall flavor of food. The mechanism for taste and smell abnormalities in cancer patients treated with systemic therapies remains unclear.

Cited by 35 publications

References 22 publications

Effects of a self-monitoring intervention in breast cancer patients suffering from taste alterations induced by chemotherapy: A randomized, parallel-group controlled trial

Effects of a self-monitoring intervention in breast cancer patients suffering from taste alterations induced by chemotherapy: A randomized, parallel-group controlled trial

Taste, smell and mouthfeel disturbances in patients with gastrointestinal stromal tumors treated with tyrosine-kinase inhibitors

The Multidisciplinary Team (MDT) Approach and Quality of Care

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