Taste Damage: Previously Unsuspected Consequences

Bartoshuk, Linda M.; Snyder, Derek J.; Grushka, Miriam; Berger, Ann M.; Duffy, Valerie B.; Kveton, John F.

doi:10.1093/chemse/bjh192

Cited by 127 publications

(72 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…236,237 Topical clonazepam has been used in the management of neuropathic oral conditions and anecdotal data in taste and smell complaints have been published. 238,239 Topical application, while relatively benign, may be a problem for patients with little or no saliva. Using a clonazepam solution may be acceptable but has not been tested.…”

Section: Managementmentioning

confidence: 99%

Oral complications of cancer and cancer therapy

Epstein

Thariat

Bensadoun

et al. 2012

CA A Cancer J Clinicians

431

356

View full text Add to dashboard Cite

Answer questions and earn CME/CNEOral complications resulting from cancer and cancer therapies cause acute and late toxicities that may be underreported, underrecognized, and undertreated. Recent advances in cancer treatment have led to changes in the incidence, nature, and severity of oral complications. As the number of survivors increases, it is becoming increasingly recognized that the aggressive management of oral toxicities is needed to ensure optimal long‐term oral health and general well‐being. Advances in care have had an impact on previously recognized oral complications and are leading to newly recognized adverse effects. Here, the authors briefly review advances in cancer therapy, including recent advances in surgery, oral care, radiation therapy, hematopoietic cell transplantation, and medical oncology; describe how these advances affect oral health; and discuss the frequent and/or severe oral health complications associated with cancer and cancer treatment and their effect upon long‐term health. Although some of the acute oral toxicities of cancer therapies may be reduced, they remain essentially unavoidable. The significant impact of long‐term complications requires increased awareness and recognition to promote prevention and appropriate intervention. It is therefore important for the primary oncologist to be aware of these complications so that appropriate measures can be implemented in a timely manner. Prevention and management is best provided via multidisciplinary health care teams, which must be integrated and communicate effectively in order to provide the best patient care in a coordinated manner at the appropriate time. CA Cancer J Clin 2012. © 2012 American Cancer Society.

show abstract

Section: Managementmentioning

confidence: 99%

Oral complications of cancer and cancer therapy

Epstein

Thariat

Bensadoun

et al. 2012

CA A Cancer J Clinicians

431

356

View full text Add to dashboard Cite

show abstract

“…Damage to the chorda tympani nerve can lead to the perception of taste phantoms (dysgeusia) and is thought to lead to the perception of oral pain phantoms as well. 18 Variation in chorda tympani nerve-mediated taste intensity has also been shown to influence vegetable consumption. 9 Unilateral reductions of taste on the tip of the tongue can be observed with unilateral sacrifice of the chorda tympani nerve during acoustic neuroma surgery.…”

Section: Choice Of Taste Stimuli For Use Inmentioning

confidence: 99%

Gustation assessment using the NIH Toolbox

et al. 2013

Self Cite

View full text Add to dashboard Cite

The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a set of brief measures for the assessment of cognitive function, emotional health, motor function, and sensory function for use in clinical trials and in epidemiologic and longitudinal studies. Gustatory perception is assessed as 1 of 6 areas of sensory function. A team of 11 scientists with expertise in taste perception selected 2 gustatory measures, 1 of which can be used in young pediatric populations. The measure selected for young pediatric populations assesses sucrose (sweet) taste preference and can also be used across the age span of 5 to 85 years. For adult populations, the selected measure is a regional test, which assesses variability in perceived intensity of quinine hydrochloride (bitter) when applied to the tongue tip as well as perceived with the whole mouth. The team also recommends the regional test for assessing other tastants, such as sodium chloride (salty). Validation studies have demonstrated that the measures modified for the NIH Toolbox correlate with more traditional assessments, and can identify known population differences in gustation. Neurology â 2013;80 (Suppl 3):S20-S24 DEFINITION OF GUSTATION Gustation consists of the perception of sensations that are usually described as having 1 or more basic taste qualities: sweet, salty, sour, bitter, or umami (savory/brothy). These sensations facilitate consumption of nutrients (sweet, salty, umami) and contribute to rejection of toxins (bitter). The gustatory system's key function in guiding food intake makes it important to health and the prevention of chronic diseases and conditions. For example, individual differences in bitter taste perception are known to contribute to differences in food preferences and consumption of certain fruits and vegetables, thereby influencing health.1 Gustation arises from the cellular activation of taste receptors that are localized to the plasma membranes of modified epithelial cells. 2Along with supporting cells, these specialized cells form taste buds that are found inside papillae on the tongue surface or within the tissues of the soft palate and pharynx. Gustatory fibers in the facial, glossopharyngeal, and vagal cranial nerves innervate taste buds in the oral cavity. These fibers carry taste information from the oral cavity to the nucleus of the solitary tract in the brainstem.3 In primates, projections from the nucleus of the solitary tract carry taste information to the thalamus, which in turn projects to gustatory cortex. 3Psychophysical measures characterize different aspects of gustatory perception. These include the responsiveness of the system to taste stimuli as well as the hedonic value of the sensation. Measures of taste function include detection thresholds, just noticeable differences in taste perception, perceived intensity, and taste quality judgments. Measurements involving hedonic value usually consist of estimates of pleasantness, liking, or preference. For children younger than age 5, most ...

show abstract

“…However, a "hit-and-run" mechanism of neuropathic pain and dysesthesia could be one of a number of mechanisms that could not be evaluated in this study of viral serology. Despite the fact that this study was limited by a small number of subjects, it was felt that HSV or other viral involvement by blood testing was unlikely to identify a viral causative agent for BMS and that either large, multi-center, epidemiologic studies are required or that different methodology including anatomical examination of taste and pain fibers surrounding the fungiform papillae (14,15), are required. While the patient sample size in this pilot study is small, the findings do not support a neuropathic role of HSV, CMV or VZV in the etiology of BMS.…”

Section: Discussionmentioning

confidence: 99%