Taste Function in Xerostomia before and after Treatment with a Saliva Substitute Containing Carboxymethylcellulose

Temmel, Andreas F P; Quint, Christian; Schickinger-Fischer, Bettina; Hummel, Thomas

doi:10.2310/7070.2005.04008

Cited by 21 publications

(13 citation statements)

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“…These findings are consistent with many other studies that have demonstrated that topical dry mouth products can improve symptoms of dry mouth in a variety of patient populations (20–24, 64–73). However, the vast majority of these clinical investigations were conducted in patients with radiotherapy‐induced salivary hypofunction or Sjögren's syndrome.…”

Section: Discussionsupporting

confidence: 92%

Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy‐induced dry mouth

Ship¹,

McCutcheon²,

Spivakovsky³

et al. 2007

J of Oral Rehabilitation

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Polypharmacy is a common cause of salivary hypofunction, producing symptoms of dry mouth or xerostomia, especially among older populations. As the number of older people continues to increase, polypharmacy-induced salivary hypofunction is becoming an increasing problem. Many over-the-counter products are available for relieving symptoms of dry mouth, but few have been tested in controlled clinical investigations. The purpose of this investigation was to evaluate the safety and efficacy of a group of topical dry mouth products (toothpaste, mouth rinse, mouth spray and gel) containing olive oil, betaine and xylitol. Forty adults were entered into this single-blinded, open-label, cross-over clinical study and 39 completed all the visits. Subjects were randomly assigned at baseline to using the novel topical dry mouth products daily for 1 week, or to maintain their normal dry mouth routine care. After 1 week, they were crossed over to the other dry mouth regimen. The results demonstrated that the use of the novel topical dry mouth products increased significantly unstimulated whole salivary flow rates, reduced complaints of xerostomia and improved xerostomia-associated quality of life. No clinically significant adverse events were observed. These data suggest that the daily use of topical dry mouth products containing olive oil, betaine and xylitol is safe and effective in relieving symptoms of dry mouth in a population with polypharmacy-induced xerostomia.

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Section: Discussionsupporting

confidence: 92%

Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy‐induced dry mouth

Ship¹,

McCutcheon²,

Spivakovsky³

et al. 2007

J of Oral Rehabilitation

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“…A variety of artificial saliva substitutes were developed to supplement the reduced production of saliva, although few were appropriately evaluated [1,13,15,17,20,21]. Because saliva is such a complex substance, it is difficult to replace.…”

Section: Discussionmentioning

confidence: 99%

“…Products based on carboxymethylcellulose (CMC) or mucin were studied for many years, albeit with mixed results [1,15,17,20,21]. A possible explanation for this observation is the fact that those saliva substitutes do not restore the immunological protection of saliva [6].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the BioXtra dry mouth care system in the treatment of radiotherapy-induced xerostomia

Dirix¹,

Nuyts²,

Poorten³

et al. 2007

Support Care Cancer

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“…The combination of radiation and chemotherapy may produce additional damage to the oral mucosa . Former studies showed that xerostomia and rhinitis sicca, which mostly occurs in patients with head and neck cancer, cause taste or smell loss . It is known that the mucus of the nose and mouth is important for smell and taste .…”

Section: Introductionmentioning

confidence: 99%

“…11 Former studies showed that xerostomia and rhinitis sicca, which mostly occurs in patients with head and neck cancer, cause taste or smell loss. [12][13][14] It is known that the mucus of the nose and mouth is important for smell and taste. 15 Patients who received tumor surgery and adjuvant radiochemotherapy in the head and neck area often suffer from dryness in the mouth or nose.…”

Section: Introductionmentioning

confidence: 99%

Liposomal treatment of xerostomia, odor, and taste abnormalities in patients with head and neck cancer

et al. 2015

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Taste Function in Xerostomia before and after Treatment with a Saliva Substitute Containing Carboxymethylcellulose

Cited by 21 publications

References 0 publications

Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy‐induced dry mouth

Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy‐induced dry mouth

Efficacy of the BioXtra dry mouth care system in the treatment of radiotherapy-induced xerostomia

Liposomal treatment of xerostomia, odor, and taste abnormalities in patients with head and neck cancer

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