The sweetness of binary mixtures of sucrose, fructose, and glucose was studied in a series of five experiments, all conducted within the framework of integration psychophysics. that is, using factorial stimulus designs with rating as the response measure. In all cases mixture sweetness was found to approximate to simple algebraic additivity at low levels of sweetness; however, additivity failed at higher levels, with the data displaying a consistent, subadditive pattern. This finding is discussed with reference to taste mechanisms, and a neural model is found to provide a plausible description of the mixture perception. The results also suggest an explanation for the synergism, or supplemental action, previously documented with sugar mixtures. I thank Linda Bartoshuk for useful discussions during preparation of this article.