Taste Loss and Taste Phantoms: A Role of Inhibition in the Taste System

Bartoshuk, Linda M.; Kveton, John F.; Yanagisawa, Ken; Catalanotto, Frank

doi:10.1007/978-4-431-68355-1_232

Cited by 28 publications

(13 citation statements)

References 18 publications

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“…In human experiments supporting this view, CT anesthesia in humans enhances taste cues on the contralateral posterior tongue (innervated by IX) [47-49]. Other observations indicate that glossopharyngeal nerve loss drives CT disinhibition in a similar manner [50], and that damage to either nerve leads to elevated somatosensory input from the trigeminal nerve [e.g., 51]. …”

Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

“…Taste phantoms are associated with several neurological disorders [e.g., 72, 73], and clinical accounts link them to conditions involving oral sensory nerve damage [50]. About 40% of healthy subjects experience taste phantoms during CT anesthesia; these sensations are usually localized to the contralateral posterior tongue (i.e., IX) and vary in quality and intensity, fading with the anesthetic.…”

Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

“…Spatial testing indicated complete IX loss, yet the phantom became more intense with whole-mouth topical anesthesia. This “nerve-stimulation phantom” was probably caused by surgical damage to IX and further disinhibited by CT anesthesia [50]. Although it remains uncertain why some individuals develop nerve-stimulation phantoms with oral sensory nerve damage, others develop release-of-inhibition phantoms, and others experience no taste disturbance at all, the defining feature of these complaints is that local suppression produces or enhances a taste illusion elsewhere in the mouth (i.e., oral disinhibition).…”

Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

See 2 more Smart Citations

Oral sensory nerve damage: Causes and consequences

Snyder

Bartoshuk

2016

Rev Endocr Metab Disord

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Oral sensations (i.e., taste, oral somatosensation, retronasal olfaction) are integrated into a composite sense of flavor, which guides dietary choices with long-term health impact. The nerves carrying this input are vulnerable to peripheral damage from multiple sources (e.g., otitis media, tonsillectomy, head injury), and this regional damage can boost sensations elsewhere in the mouth because of central interactions among nerve targets. Mutual inhibition governs this compensatory process, but individual differences lead to variation in whole-mouth outcomes: some individuals are unaffected, others experience severe loss, and some encounter sensory increases that may (if experienced early in life) elevate sweet-fat palatability and body mass. Phantom taste, touch, or pain sensations (e.g., burning mouth syndrome) may also occur, particularly in those expressing the most taste buds. To identify and treat these conditions effectively, emerging clinical tests measure regional vs. whole-mouth sensation, stimulated vs. phantom cues, and oral anatomy. Scaling methods allowing valid group comparisons have strongly aided these efforts. Overall, advances in measuring oral sensory function in health and disease show promise for understanding the varied clinical consequences of nerve damage.

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Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

See 1 more Smart Citation

Oral sensory nerve damage: Causes and consequences

Snyder

Bartoshuk

2016

Rev Endocr Metab Disord

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“…In patients with BMS, taste alterations, especially to bitter stimuli in areas of the tongue innervated by the chorda tympani and the glossopharyngeal nerves, have been reported (12,13). Selective damage to the sensation of taste may result in a central loss of inhibition to pain, and may cause spontaneous taste and pain 'phantoms' resulting in BMS.…”

Section: Brûlures De Bouche Et Autres Troubles Sensoriels Buccaux : Hmentioning

confidence: 99%

Burning Mouth Syndrome and Other Oral Sensory Disorders: A Unifying Hypothesis

Grushka

Epstein

Gorsky

2003

Pain Research and Management

104

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Burning Mouth Syndrome (BMS) is a sensory disorder which results in constant, bilateral burning pain of the tongue, lips, and other oral mucous membranes. Atypical odontalgia (AO) is another sensory disorder, usually defined as a toothache-like pain for which no dental cause can be identified. Previous literature has suggested that AO is often associated with a concomitant temporomandibular disorder (TMD). This hypothesis paper explores the possibility that BMS, AO and TMD can be related through hyperactivity of both the sensory and motor components of the trigeminal nerve following loss of central inhibition as a result of taste damage in the chorda tympani and/or the glossopharyngeal nerves.

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“…Although hormonal changes at menopause have long been considered to be important factors in BMS (1), there has been little convincing evidence of the efficacy of hormone replacement therapy (HRT) in postmenopausal subjects with BMS. On the other hand, the ability to taste bitter is under hormonal control and has been found to be reduced following menopause (10,12,13). In many BMS subjects, this ability to taste bitter at the chorda tympani has been shown to be severely reduced or abolished.…”

Section: Bms: Clinical Featuresmentioning

confidence: 99%

Burning mouth syndrome: differential diagnosis

Grushka

Epstein²,

Gorsky

2002

Dermatol Ther

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Burning mouth syndrome (BMS) has been defined as a burning pain of the tongue or other oral mucous membranes in an individual who exhibits no clinical signs and no related laboratory findings. Recently this concept has been disputed as being too restrictive; it has been suggested instead that BMS may exist coincidentally with other oral conditions. BMS may be linked to other orofacial pain problems, such as atypical odontalgia (AO), temporomandibular disorder (TMD), and other sensory dysesthesia.

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Taste Loss and Taste Phantoms: A Role of Inhibition in the Taste System

Cited by 28 publications

References 18 publications

Oral sensory nerve damage: Causes and consequences

Oral sensory nerve damage: Causes and consequences

Burning Mouth Syndrome and Other Oral Sensory Disorders: A Unifying Hypothesis

Burning mouth syndrome: differential diagnosis

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