Taste Masking of Nizatidine Using Ion-Exchange Resins

Panraksa, Pattaraporn; Boonsermsukcharoen, Kasidech; Hwang, Kyu-Mok; Park, Eun-Seok; Jantrawut, Pensak

doi:10.3390/pr7110779

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…The nizatidine showed high complexation efficiency in a stoichiometric ratio of 1:3 (drug:resin) with Dowex-50 because of like-charged ions, the H + compared to Amberlite IRP-69 with Na + ions. The dissolution studies exhibited the complete release within 1 h. The in vivo taste masking studies reported a pleasant taste for the DRC [115].…”

Section: Drug-resin Complexes (Drc)mentioning

confidence: 85%

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

et al. 2023

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Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main problem encountered during the formulation development of new actives and for generic development. A complexation approach has been widely investigated to address this issue, which subsequently improves the bioavailability of these drugs. This review discusses the various types of complexes such as metal complex (drug-metal ion), organic molecules (drug-caffeine or drug-hydrophilic polymer), inclusion complex (drug-cyclodextrin), and pharmacosomes (drug-phospholipids) that improves the aqueous solubility, dissolution, and permeability of the drug along with the numerous case studies reported in the literature. Besides improving solubility, drug-complexation provides versatile functions like improving stability, reducing the toxicity of drugs, increasing or decreasing the dissolution rate, and enhancing bioavailability and biodistribution. Apart, various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex are discussed. Graphical Abstract

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Section: Drug-resin Complexes (Drc)mentioning

confidence: 85%

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

et al. 2023

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“…Patients report feeling satisfied with their treatment after using this tried-and-true dose form, which features improved absorption. [38][39] It was observed that, out of the three resins that were put to the test, Indion 204 had the best results when combined with a ratio of 1:1.5, which made it possible for the most complexation to take place after only four hours of stirring. The resinate is processed into granules, which are characterised by adequate levels of angle of repose, bulk density, and flow property respectively.…”

Section: Discussionmentioning

confidence: 99%

Design of Fast Dissolving Oral Film of Lamivudine using Ion Exchange Resins Indion 204, Tulsion 335 and Doshion P551

Bidkar¹,

Rao²,

Dama³

et al. 2022

IJDDT

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Ion exchange resigns are suitable for usage as flavor masking agents and sustained pharmaceutical release due to their inherent properties such as high ion exchangeability, modified administration capacity, physiochemical stability, and non-solubility in any solvent. Ion-exchange resins (IERs) are macromolecular polymers with differing cationic and anionic functional groups qualitatively as well as quantitatively. The polymer chain is fabricated in such a way that it consists of different salt-forming groups in repeating mode. In this study, we have tried to create a rapid dissolving oro-film of lamivudine using the ion exchange resins indion 204, tulsion 335, and doshion P551. FDOFs attempt to boost patient compliance by shortening the time it takes for the treatment to take effect, in addition to having a quick onset of action and higher bioavailability and also it’s a conventional dosage form. Out of three different resins, indion 204 gives a very excellent result with 1:1.5 ratio, where the maximum amount of complexation is within 4 hours of stirring. Their resinate are converted into granules and exhibit satisfactory value of angle of repose, bulk density, and flow property. Drug loading with indion 204 resin showed above 94%.”

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“…The powders or microspheres considered for this review (Table S1) were mainly prepared through spray drying. In these cases, the bitter-tasting drug was formulated with taste-masking polymers, such as various types of Eudragit ® [57,80], two types of Kollicoat ® [81] or carrageenan [82], cellulose derivates [83], or cation-exchange resins [84]. In one study, taste masking was achieved by using nanoemulsions of different oils.…”

Section: Powders Microspheres and Granulesmentioning

confidence: 99%

“…Samples for e-tongue measurements were typically prepared as follows: the powders were dissolved in from 5 to 100 mL of water or artificial saliva buffer solution for a duration of from 30 to 300 s [56,57,84,87]. A filtration step was then performed using 0.45 µm membrane filters to remove insoluble components or any remaining particles, ensuring a particle-free solution [57,84] (Figure 4).…”

Section: Powders Microspheres and Granulesmentioning

confidence: 99%

Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients

Steiner,

Meyer,

Immohr

et al. 2024

Pharmaceutics

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In this review, we aim to highlight the advantages, challenges, and limitations of electronic tongues (e-tongues) in pharmaceutical drug development. The authors, therefore, critically evaluated the performance of e-tongues regarding their qualification to assess peroral formulations containing bitter active pharmaceutical ingredients. A literature search using the keywords ‘electronic’, ‘tongue’, ‘bitter’, and ‘drug’ in a Web of Science search was therefore initially conducted. Reviewing the publications of the past decade, and further literature where necessary, allowed the authors to discuss whether and how e-tongues perform as expected and whether they have the potential to become a standard tool in drug development. Specifically highlighted are the expectations an e-tongue should meet. Further, a brief insight into the technologies of the utilized e-tongues is given. Reliable protocols were found that enable (i) the qualified performance of e-tongue instruments from an analytical perspective, (ii) proper taste-masking assessments, and (iii) under certain circumstances, the evaluation of bitterness.

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Taste Masking of Nizatidine Using Ion-Exchange Resins

Cited by 10 publications

References 21 publications

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

Design of Fast Dissolving Oral Film of Lamivudine using Ion Exchange Resins Indion 204, Tulsion 335 and Doshion P551

Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients

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