Taste of Ten Drugs Frequently Prescribed in Nursing Homes Crushed and Mixed in Food: Observational Study in 16 Healthy Volunteers

Lamure, Julie; Brocker, P.; Schneider, Stéphane; Collomp, Rémy; Bertin-Hugault, François; Denormandie, P.; Prêcheur, Isabelle

doi:10.14283/jnhrs.2015.12

Jour Nursing Home Res

2015

DOI: 10.14283/jnhrs.2015.12

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Taste of Ten Drugs Frequently Prescribed in Nursing Homes Crushed and Mixed in Food: Observational Study in 16 Healthy Volunteers

Julie Lamure¹,

P. Brocker²,

Stéphane Schneider³

et al.

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In Vitro Screening of the Antibacterial and Anti- Candida Properties of Crushed Nonantimicrobial Drugs Frequently Prescribed in Nursing Homes

Lamure¹,

Chevalier²,

Rathelot³

et al. 2018

Research in Gerontological Nursing

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Frail older adults often experience swallowing disorders, prompting nursing staff to crush tablets, open capsules, and mix drugs into their meals or gelled water. However, crushing drugs can lead to pharmacological and gustatory problems. As crushed drugs can stay in prolonged contact with oral microbial biofilm, the current study aimed to investigate their antimicrobial properties. Crushed drugs were diluted in 1 mL of isotonic water and assayed in vitro for: (a) growth inhibition of five bacterial strains and Candida albicans by the diffusion method; (b) inhibition of Streptococcus salivarius and C. albicans biofilm formation; and (c) elimination of a preformed biofilm of S. salivarius and C. albicans after 5-minute contact. Eight of 29 crushed drugs inhibited bacterial and/or fungal growth on agar plates. Twenty-eight of 29 crushed drugs reduced the total biomass when incubated with S. salivarius, and 28 of 29 crushed drugs inhibited C. albicans biofilm formation. Preformed biomass was reduced by ≥25% by seven of 29 drugs. Crushed drugs may unbalance oral ecosystems and contribute to oral inflammation. [Res Gerontol Nurs. 2018; 11(2):82-90.].

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In Vitro Screening of the Antibacterial and Anti- Candida Properties of Crushed Nonantimicrobial Drugs Frequently Prescribed in Nursing Homes

Lamure¹,

Chevalier²,

Rathelot³

et al. 2018

Research in Gerontological Nursing

View full text Add to dashboard Cite

show abstract

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Taste of Ten Drugs Frequently Prescribed in Nursing Homes Crushed and Mixed in Food: Observational Study in 16 Healthy Volunteers

Cited by 1 publication

References 0 publications

In Vitro Screening of the Antibacterial and Anti- Candida Properties of Crushed Nonantimicrobial Drugs Frequently Prescribed in Nursing Homes

In Vitro Screening of the Antibacterial and Anti- Candida Properties of Crushed Nonantimicrobial Drugs Frequently Prescribed in Nursing Homes

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