Taste Perception and Caffeine Consumption: An fMRI Study

Gramling, Laura; Kapoulea, Eleni A.; Murphy, Claire

doi:10.3390/nu11010034

Cited by 12 publications

(8 citation statements)

References 63 publications

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“…During the hedonic evaluation of caffeine or sucrose, caffeine non-consumers had greater activation in neuronal areas associated with memory and reward, while during the hedonic evaluation of saccharin, greater activation in neuronal areas associated with memory, reward, and information processing occurred in the group of caffeine consumers. The results of the above studies support the observations on differential memory, reward, and information processing of taste between those who habitually consume caffeine and those who do not [50].…”

Section: Caffeine and Taste Perceptionsupporting

confidence: 83%

“…Gramling et al [ 50 ] examined 12 males and 16 females (both caffeine consumers and non-consumers) using functional magnetic resonance imaging (fMRI), and showed differences in blood-oxygenation-level-dependent activation. The study was based on hedonic evaluation of caffeine, sucrose, or saccharin.…”

Section: The Role Of Caffeine In Various Systems In the Human Bodymentioning

confidence: 99%

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Caffeine as a Factor Influencing the Functioning of the Human Body—Friend or Foe?

2021

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Nowadays, caffeine is one of the most commonly consumed substances, which presents in many plants and products. It has both positive and negative effects on the human body, and its activity concerns a variety of systems including the central nervous system, immune system, digestive system, respiratory system, urinary tract, etc. These effects are dependent on quantity, the type of product in which caffeine is contained, and also on the individual differences among people (sex, age, diet etc.). The main aim of this review was to collect, present, and analyze the available information including the latest discoveries on the impact of caffeine on human health and the functioning of human body systems, taking into account the role of caffeine in individual disease entities. We present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson’s disease, and others, not forgetting about the negative effects of excess caffeine (e.g., in people with hypertension, children, adolescents, and the elderly). In summary, we can conclude, however, that caffeine has a multi-directional influence on various organs of the human body, and because of its anti-oxidative properties, it was, and still is, an interesting topic for research studies including those aimed at developing new therapeutic strategies.

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Section: Caffeine and Taste Perceptionsupporting

confidence: 83%

Section: The Role Of Caffeine In Various Systems In the Human Bodymentioning

confidence: 99%

Caffeine as a Factor Influencing the Functioning of the Human Body—Friend or Foe?

2021

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“…The other network impacted by coffee intake was the limbic network, which is involved in processing the sensory input from the external and internal environment which, by modulating memory and motivation, determine emotional, autonomic, motor, and cognitive responses [45]. A previous resting-state PET study showed reduced metabolic activity in components of this network after caffeine ingestion [18] and a study using a hedonic fMRI task showed decreased activation in neuronal areas associated with memory and reward [46] in caffeine consumers compared to non-consumers; the present FC data are consistent with those reports.…”

Section: Discussionmentioning

confidence: 99%

Habitual coffee drinkers display a distinct pattern of brain functional connectivity

et al. 2021

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Coffee is the most widely consumed source of caffeine worldwide, partly due to the psychoactive effects of this methylxanthine. Interestingly, the effects of its chronic consumption on the brain’s intrinsic functional networks are still largely unknown. This study provides the first extended characterization of the effects of chronic coffee consumption on human brain networks. Subjects were recruited and divided into two groups: habitual coffee drinkers (CD) and non-coffee drinkers (NCD). Resting-state functional magnetic resonance imaging (fMRI) was acquired in these volunteers who were also assessed regarding stress, anxiety, and depression scores. In the neuroimaging evaluation, the CD group showed decreased functional connectivity in the somatosensory and limbic networks during resting state as assessed with independent component analysis. The CD group also showed decreased functional connectivity in a network comprising subcortical and posterior brain regions associated with somatosensory, motor, and emotional processing as assessed with network-based statistics; moreover, CD displayed longer lifetime of a functional network involving subcortical regions, the visual network and the cerebellum. Importantly, all these differences were dependent on the frequency of caffeine consumption, and were reproduced after NCD drank coffee. CD showed higher stress levels than NCD, and although no other group effects were observed in this psychological assessment, increased frequency of caffeine consumption was also associated with increased anxiety in males. In conclusion, higher consumption of coffee and caffeinated products has an impact in brain functional connectivity at rest with implications in emotionality, alertness, and readiness to action.

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“…Four studies reported results from sugars and sweeteners separately [ 13 , 17 , 20 , 21 ]. Two of them concluded that sugars elicited responses in more brain regions than sweeteners.…”

Section: Discussionmentioning

confidence: 99%

How Does Our Brain Process Sugars and Non-Nutritive Sweeteners Differently: A Systematic Review on Functional Magnetic Resonance Imaging Studies

Yeung

Wong

2020

Nutrients

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This systematic review aimed to reveal the differential brain processing of sugars and sweeteners in humans. Functional magnetic resonance imaging studies published up to 2019 were retrieved from two databases and were included into the review if they evaluated the effects of both sugars and sweeteners on the subjects’ brain responses, during tasting and right after ingestion. Twenty studies fulfilled the inclusion criteria. The number of participants per study ranged from 5 to 42, with a total number of study participants at 396. Seven studies recruited both males and females, 7 were all-female and 6 were all-male. There was no consistent pattern showing that sugar or sweeteners elicited larger brain responses. Commonly involved brain regions were insula/operculum, cingulate and striatum, brainstem, hypothalamus and the ventral tegmental area. Future studies, therefore, should recruit a larger sample size, adopt a standardized fasting duration (preferably 12 h overnight, which is the most common practice and brain responses are larger in the state of hunger), and reported results with familywise-error rate (FWE)-corrected statistics. Every study should report the differential brain activation between sugar and non-nutritive sweetener conditions regardless of the complexity of their experiment design. These measures would enable a meta-analysis, pooling data across studies in a meaningful manner.

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Taste Perception and Caffeine Consumption: An fMRI Study

Cited by 12 publications

References 63 publications

Caffeine as a Factor Influencing the Functioning of the Human Body—Friend or Foe?

Caffeine as a Factor Influencing the Functioning of the Human Body—Friend or Foe?

Habitual coffee drinkers display a distinct pattern of brain functional connectivity

How Does Our Brain Process Sugars and Non-Nutritive Sweeteners Differently: A Systematic Review on Functional Magnetic Resonance Imaging Studies

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