Taste perception genomics in gestational diabetes mellitus: A systematic review

A meta-analysis on polymorphic trait of taste perception mediated by TAS2R38 genotype.

“…TAS2R38, located on chromosome 7q36, is one of the genes influencing the ability to taste bitterness to bitter containing compounds such as thiocyanate, caffeine, quinine, β-glucopyranosides, and expressed predominantly in the oral cavity and other sites such as gastrointestinal tract and lungs (Barajas-Ramírez et al, 2016;Barbarossa et al, 2015;Cáceres et al, 2023;Calò et al, 2011;Duffy et al, 2004;Khataan et al, 2010;Mennella et al, 2005;Schembre et al, 2013). Studies reported that TAS2R38 polymorphisms are associated with obesity, higher body mass index, metabolic disorders, thyroid dysfunction, gestational diabetes mellitus, Parkinson's disease, autism spectrum disorder, anorexia nervosa, carcinogenesis, longevity, and chronic health disorders (Cerri et al, 2019;Choi et al, 2017;Costa et al, 2023;Ortega et al, 2016;Riccio et al, 2018;Shivam et al, 2024;Tepper et al, 2008). Several studies reported around nine combinations of polymorphisms in TAS2R38 gene such as proline-alanine-valine (PAV), alanine-valine-isoleucine (AVI), alanine-alanine-valine, alanine-alanine-isoleucine, prolinevaline-isoleucine, proline-alanine-valine, proline-valine-isoleucine, This document is copyrighted by the American Psychological Association or one of its allied publishers.…”