Taste responses of cortical neurons in freely ingesting rats

Yamamoto, Takashi; Matsuo, Ryuji; Kiyomitsu, Yoshitaka; Kitamura, Ryosuke

doi:10.1152/jn.1989.61.6.1244

Cited by 148 publications

(107 citation statements)

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“…0.38). On the contrary, the higher correlation between saccharin and quinine in the CTA group indicates that the cortical territories activated by the two tastants are more similar and this might directly be associated to the shift of tastant (CS) hedonic value, supporting the view of the GC as an important site for processing taste hedonics (13,14,19).…”

Section: Resultsmentioning

confidence: 77%

“…We took advantage of the unique features of the central taste system where changes in internal body states, such as satiety (20) or visceral malaise (16,19) have a direct influence on primary GC neuronal responses.…”

Section: Discussionmentioning

confidence: 99%

“…The role of the insular cortex (containing primary GC) in CTA has been the topic of several studies (12,21). Electrophysiological recordings in the GC showed that some neurons vary their response pattern before and after CTA (19,32). Cortical lesions studies demonstrated that the insular cortex (that contains the GC) is important for CTA acquisition (11,33), although some particular insular lesions only partially disrupt CTA (34).…”

Section: Discussionmentioning

confidence: 99%

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Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Accolla

Carleton²

2008

Proc. Natl. Acad. Sci. U.S.A.

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Primary sensory cortices are remarkably organized in spatial maps according to specific sensory features of the stimuli. These cortical maps can undergo plastic rearrangements after changes in afferent (''bottom-up'') sensory inputs such as peripheral lesions or passive sensory experience. However, much less is known about the influence of ''top-down'' factors on cortical plasticity. Here, we studied the effect of a visceral malaise on taste representations in the gustatory cortex (GC). Using in vivo optical imaging, we showed that inducing conditioned taste aversion (CTA) to a sweet and pleasant stimulus induced plastic rearrangement of its cortical representation, becoming more similar to a bitter and unpleasant taste representation. Using a behavior task, we showed that changes in hedonic perception are directly related to the maps plasticity in the GC. Indeed imaging the animals after CTA extinction indicated that sweet and bitter representations were dissimilar. In conclusion, we showed that an internal state of malaise induces plastic reshaping in the GC associated to behavioral shift of the stimulus hedonic value. We propose that the GC not only encodes taste modality, intensity, and memory but extends its integrative properties to process also the stimulus hedonic value.chemical senses ͉ map plasticity ͉ taste coding

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Section: Resultsmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Accolla

Carleton²

2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Further, a more recent study using neuronal activity mapping with Arc mRNA (Saddoris et al 2009) indicates that the integration of taste-related information mostly occurs in the anterior dysgranular region of the IC. Finally, based on early electrophysiological evidence (Yamamoto et al 1989), as well as in preliminary findings from our lab with Arc immunohistochemistry, we determined that layers IV/V best responded to taste stimulation. For these reasons, we decided to focus on the medial to deep layers of the dysgranular IC to perform our immunohistochemical analysis (Supplemental Fig.…”

Section: Resultsmentioning

confidence: 99%

Familiar taste induces higher dendritic levels of activity-regulated cytoskeleton-associated protein in the insular cortex than a novel one

Morin

Quiroz²,

Mendoza-Viveros³

et al. 2011

Learn. Mem.

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The immediate early gene (IEG) Arc is known to play an important role in synaptic plasticity; its protein is locally translated in the dendrites where it has been involved in several types of plasticity mechanisms. Because of its tight coupling with neuronal activity, Arc has been widely used as a tool to tag behaviorally activated networks. However, studies examining the modulation of Arc expression during and after learning have yielded somewhat contradictory results. Although some have reported that higher levels of Arc were induced by initial acquisition of a task rather than by reinstating a learned behavior, others have failed to observe such habituation of Arc transcription. Moreover, most of these studies have focused on the mRNA and, surprisingly, relatively little is known about how learning can affect Arc protein expression levels. Here we used taste recognition memory and examined Arc protein expression in the insular cortex of rats at distinct times during taste memory formation. Interestingly, we found that more Arc protein was induced by a familiar rather than by a novel taste. Moreover, this increase was inhibited by post-trial intrahippocampal anisomycin injections, a treatment known to inhibit safe-taste memory consolidation. In addition, confocal microscopy analysis of immunofluorescence stained tissue revealed that the proportion of IC neurons expressing Arc was the same in animals exposed to novel and familiar taste, but Arc immunoreactivity in dendrites was dramatically higher in rats exposed to the familiar taste. These results provide novel insights on how experience affects cortical plasticity.

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“…In these experiments, tastants were delivered only after water-deprived and head-restrained animals were sufficiently motivated to press a bar to receive both hedonically positive and negative tastants. Responses in the GC were investigated because it a primary cortical area involved in the processing of gustatory information [4,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Behavioral and neural responses to gustatory stimuli delivered non-contingently through intra-oral cannulas

Soares

Stapleton

Rodríguez

et al. 2007

Physiology & Behavior

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The act of eating requires a decision by an animal to place food in its mouth. The reasons to eat are varied and include hunger as well as the food's expected reward value. Previous studies of tastant processing in the rat primary gustatory cortex (GC) have used either anesthetized or awake behaving preparations that yield somewhat different results. Here we have developed a new preparation in which we explore the influences of intra-oral and non-contingent tastant delivery on rats' behavior and on their GC neural responses. We recorded single unit activity in the rat GC during two sequences of tastant deliveries, PRE and POST, which were separated by a waiting period. Six tastants ranging in hedonic value from sucrose to quinine were delivered in the first two protocols called 4TW and L-S. In the third one, the App L-S protocol, only hedonically positive tastants were used. In the 4TW protocol, tastants were delivered in blocks whereas in the two L-S protocols tastants were randomly interleaved.In the 4TW and L-S protocols the probability of ingesting tastants in the PRE sequence decreased exponentially with the trial number. Moreover, in both protocols this decrease was greater in the POST than in the PRE sequence likely because the subjects learned that unpleasant tastants were to be delivered. In the App L-S protocol the decrease in ingestion was markedly slower than in the other protocols, thus supporting the hypothesis that the decrease in appetitive behavior arises from the noncontingent intra-oral delivery of negatively hedonic tastants like quinine.Although neuronal responses in the three protocols displayed similar variability levels, significant differences existed between the protocols in the way the variability was partitioned between chemosensory and non-chemosensory neurons. While in the 4TW and L-S protocols the former population displayed more changes than the latter, in the App L-S protocol variability was homogeneously distributed between the two populations. We posit that these tuning changes arise,

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Taste responses of cortical neurons in freely ingesting rats

Cited by 148 publications

References 0 publications

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Familiar taste induces higher dendritic levels of activity-regulated cytoskeleton-associated protein in the insular cortex than a novel one

Behavioral and neural responses to gustatory stimuli delivered non-contingently through intra-oral cannulas

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