Tasting inhibition: A proof-of-concept study of the food stop-signal game

Kirsten, Hannah; Dechant, Martin; Gibbons, Henning; Friehs, Maximilian A.

doi:10.1016/bs.pbr.2022.12.002

Cited by 6 publications

(2 citation statements)

References 75 publications

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“…Overall, performance was in the expected range, and comparable to previous studies utilizing a similar gamified task version Kirsten et al, 2023;Schroeder et al, 2021Schroeder et al, , 2023.…”

Section: Resultssupporting

confidence: 84%

Effects of 1 Hz offline TMS on performance in the stop-signal game

Friehs¹,

Hartwigsen²,

Matzke³

et al. 2023

Preprint

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Stopping an already initiated action is crucial for human everyday behavior and empirical evidence points toward the prefrontal cortex playing a key role in response inhibition. Two regions that have been consistently implicated in response inhibition are the right inferior frontal gyrus (IFG) and the more superior region of the dorsolateral prefrontal cortex (DLPFC). The present study investigated the effect of offline 1 Hz transcranial magnetic stimulation (TMS) over the right IFG and DLPFC on performance in a gamified stop-signal task (SSG). We hypothesized that perturbing each area would decrease performance in the SSG, albeit with a quantitative difference in the performance decrease after stimulation. After offline TMS, functional short-term reorganization is possible, and the domain-general area (i.e., the right DLPFC) might be able to compensate for the perturbation of the domain-specific area (i.e., the right IFG). Results showed that 1 Hz offline TMS over the right DLPFC and the right IFG at 110% intensity of the resting motor threshold had no effect on performance in the SSG. In fact, evidence in favor of the null hypothesis was found. One theoretically intriguing interpretation of this result is that within-network compensation was triggered, canceling out the potential TMS effects as has been suggested in recent theorizing on TMS effects. This interpretation is particularly intriguing given that our task was closer to a real-life situation due to its increased complexity as compared to the standard stop-signal task version.

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Section: Resultssupporting

confidence: 84%

Effects of 1 Hz offline TMS on performance in the stop-signal game

Friehs¹,

Hartwigsen²,

Matzke³

et al. 2023

Preprint

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show abstract

“…In fact, recent evidence suggest that older adults and children can benefit from additional manipulations of classical cognitive tasks, such as the addition of affective information (Zinchenko et al 2017 , 2019 ). Similarly, understanding the basis of response inhibition in the healthy population could inspire new and improved interventions for psychiatric disorders, such as substance abuse, binge-eating, compulsive gambling, ADHD, and obsessive compulsive disorder; all of which correlate with reduced response inhibition (Goudriaan et al 2006 ; Kirsten et al 2022 ; Lijffijt et al 2005 ; Lipszyc and Schachar 2010 ; Woolley et al 2008 ).…”

Section: Discussionmentioning

confidence: 99%

A touching advantage: cross-modal stop-signals improve reactive response inhibition

Friehs,

Schmalbrock,

Merz

et al. 2024

Exp Brain Res

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The ability to inhibit an already initiated response is crucial for navigating the environment. However, it is unclear which characteristics make stop-signals more likely to be processed efficiently. In three consecutive studies, we demonstrate that stop-signal modality and location are key factors that influence reactive response inhibition. Study 1 shows that tactile stop-signals lead to better performance compared to visual stop-signals in an otherwise visual choice-reaction task. Results of Study 2 reveal that the location of the stop-signal matters. Specifically, if a visual stop-signal is presented at a different location compared to the visual go-signal, then stopping performance is enhanced. Extending these results, study 3 suggests that tactile stop-signals and location-distinct visual stop-signals retain their performance enhancing effect when visual distractors are presented at the location of the go-signal. In sum, these results confirm that stop-signal modality and location influence reactive response inhibition, even in the face of concurrent distractors. Future research may extend and generalize these findings to other cross-modal setups.

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