TAT-based formal representation of medical guidelines: Imatinib case-study

Abstract

Abstract-Computer-based interpretation of medical guidelines (GLs) has drawn lots of attention in the past three decades. It is essential to use a formalism for GLs representation that would enable the validation of GLs structural properties, be able to map medical actions into the time scale and support the automatic formal verification of GLs without additional translation paths. In this paper we preset a novel approach based on Timed Automata extended with Tasks (TAT) for the medical protocol formal representation using the TIMES toolbox. We discuss the verification issues with the help of the Imatinib case study.

Medical guidelines reconciling medical software and electronic devices: Imatinib case-study

“…Therefore, a graphical interpretation is a big advantage. We use TAT as a key formalism for protocols representation [23], since TIMES tool includes not only a GUI for system modeling but also a model-checker engine that supports verification of system properties that are expressed with CTL logic. A medical GL represented using TAT can be turned into a fully deterministic model [7] thus enabling further embedded or decision-support system code synthesis step.…”

“…In this paper we show that a novel approach of [23] for the medical GLs formal representation can bridge the gap between medical software and electronic devices. The approach is based on GLs formal representation with Timed Automaton extended with Tasks (TAT) [7] and exploits the TIMES toolbox [3] aimed to support the modeling and verification of real-time systems.…”

A Drug Administration Decision Support System

“…DADSS can be considered as a solid brick for any general DSS aimed at assisting medical doctors when applying the TDM approach. For instance, it can close the verification loop of the TAT-based medical protocol representation [15] by bridging the modeling gap between treatment applied to a patient and its body reaction to the treatment.…”

Safe Implementation of Embedded Software for a Portable Device Supporting Drug Administration

“…The automatization of such decision-making requires the computer-interpretable GLs representation. In our prior works [24], [25] we have presented an example of medical GL representation applying the TAT formal model. As was defined in Section II-A, TAT allows modeling of a system by composing it out of several TAT models combined into a network of interoperating automata.…”