Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation

Luo, Zhenzhao; Liu, Li; Li, Xing; Chen, Weiqun; Lu, Zhongxin

doi:10.1007/s10571-021-01134-y

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…ANXA1 has been extensively studied in gastric cancer and breast cancer ( Maschler et al, 2010 ; Cheng et al, 2012 ). Some studies in gliomas have shown that ANXA1 is a risk prognostic factor ( Xu et al, 2017 ; Luo et al, 2021 ; Wei et al, 2021 ) Therefore, we investigated the expression, prognosis, and related mechanisms of ANXA1 using a public database to provide new markers and potential therapeutic targets for glioma patients.…”

Section: Introductionmentioning

confidence: 99%

ANXA1: An Important Independent Prognostic Factor and Molecular Target in Glioma

et al. 2022

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Objective: The expression, prognosis, and related mechanisms of ANXA1 are investigated in glioma, with the objective to find potential therapeutic molecular targets for glioma.Methods: We analyzed the gene expression of ANXA1 using glioma-related databases, including the Chinese Glioma Genome Atlas (CGGA) database, The Cancer Genome Atlas (TCGA) database, and the Gene Expression Omnibus (GEO) database. Moreover, we collected the sample tissues and corresponding paracancerous tissues of 23 glioma patients and then conducted a Western blot experiment to verify the expression and correlate survival of ANXA1. Moreover, we generated survival ROC curves, performing univariate and multivariate Cox analyses and the construction of the nomogram. Differential expression analysis was conducted by high and low grouping based on the median of the ANXA1 gene expression values. We conducted Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and Gene Set Enrichment Analysis (GSEA) to explore possible mechanisms, and gene co-expression analysis was also performed.Results: The results showed that the ANXA1 expression level was higher in gliomas than in normal tissues, and a high expression level of ANXA1 in gliomas was associated with poorer prognosis. The independent prognosis analysis showed that the ANXA1 gene was an independent prognostic factor of glioma. In the analysis of KEGG and Gene Set Enrichment Analysis (GSEA), it is shown that ANXA1 may play an important role in glioma patients by affecting extracellular matrix (ECM)–receptor interaction and the focal adhesion signal pathway. The core genes, including COL1A1, COL1A2, FN1, ITGA1, and ITGB1, were screened for gene correlation and prognosis analysis. The expression level of the five genes was verified by qPCR in glioma. We concluded that these five core genes and ANXA1 could play a synergistic role in gliomas.Conclusion: The results indicated that a high expression level of ANXA1 leads to worse prognosis and ANXA1 is an independent prognostic factor and a potentially important target for the treatment of gliomas.

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Section: Introductionmentioning

confidence: 99%

ANXA1: An Important Independent Prognostic Factor and Molecular Target in Glioma

et al. 2022

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“…RNF12 is involved in down-regulation of RB1 and induces MAPK in GBM progression [ 88 ]. Tat-NTS is suggested to be involved in preventing nuclear translocation of annexin-A1 for carcinogenesis [ 89 ].…”

Section: Lncrnas In Proliferation and Invasionmentioning

confidence: 99%

Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma

Hashemi,

Mousavian Roshanzamir,

Orouei

et al. 2024

Non-coding RNA Research

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“…Eriodictyol, a natural flavonoid, can suppress GBM cell migration and invasion by downregulating the PI3K/AKT/NF-κB pathway [ 102 ]. Tat-NTS is a synthesized small molecular peptide that represses annexin-A1 (ANXA1) nuclear translocation, and it can suppress GBM cell migration and invasion by diminishing the phosphorylation level of p65 [ 103 ]. Fentanyl can inhibit p65 activation to decrease the invasiveness of GBM cells [ 104 ].…”

Section: Nf-κb Activation Is Involved In Development and Progression ...mentioning

confidence: 99%

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

Shi

Cui

2023

IJMS

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Glioblastoma multiforme (GBM) is the most common and invasive primary central nervous system tumor in humans, accounting for approximately 45–50% of all primary brain tumors. How to conduct early diagnosis, targeted intervention, and prognostic evaluation of GBM, in order to improve the survival rate of glioblastoma patients, has always been an urgent clinical problem to be solved. Therefore, a deeper understanding of the molecular mechanisms underlying the occurrence and development of GBM is also needed. Like many other cancers, NF-κB signaling plays a crucial role in tumor growth and therapeutic resistance in GBM. However, the molecular mechanism underlying the high activity of NF-κB in GBM remains to be elucidated. This review aims to identify and summarize the NF-κB signaling involved in the recent pathogenesis of GBM, as well as basic therapy for GBM via NF-κB signaling.

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Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation

Cited by 6 publications

References 38 publications

ANXA1: An Important Independent Prognostic Factor and Molecular Target in Glioma

ANXA1: An Important Independent Prognostic Factor and Molecular Target in Glioma

Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

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