Tat peptide and hexadecylphosphocholine introduction into pegylated liposomal doxorubicin: An in vitro and in vivo study on drug cellular delivery, release, biodistribution and antitumor activity

Teymouri, Manouchehr; Badiee, Ali; Golmohammadzadeh, Shiva; Sadri, Kayvan; Akhtari, Javad; Mellat, Mostafa; Nikpoor, Amin Reza; Jaafari, Mahmoud Reza

doi:10.1016/j.ijpharm.2016.06.117

Cited by 26 publications

(15 citation statements)

References 31 publications

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“…The linkage efficacy was monitored by silica thin layer chromatography (TLC) with a developing solvent of chloroform/methanol/water (90/10/2) and iodine vapor exposure. Then, the solvents were removed under a warmed nitrogen stream and the tube’s content was freeze-dried overnight 46 . The resulting white powder was re-suspended in an appropriate amount of deionized water.…”

Section: Methodsmentioning

confidence: 99%

Liposomal formulation of Galbanic acid improved therapeutic efficacy of pegylated liposomal Doxorubicin in mouse colon carcinoma

Nik

Malaekeh‐Nikouei

Amin

et al. 2019

Sci Rep

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Galbanic acid (Gba), a sesquiterpene coumarin , with strong antiangiogenic activity could serve as an excellent anti-cancer agent. However, Gba is a poor water-solube which hampered its clinical application. In this study, a pegylated liposomal Gba (PLGba) with HSPC/Cholesterol/mPEG 2000 -DSPE (56.2, 38.3, 5.3% molar ratio) was developed by the thin film hydration plus extrusion and calcium acetate gradient remote loading method, to address the issue of poor Gba solubility. Moreover, an integrin-targeting ligand (RGD peptide, cyclo[Arg-Gly-Asp-D-Tyr-Cys]) was post-inserted into liposomes in order to increase Gba cell delivery. Using fluorescently-labeled model liposomes, it was found that the targeting could improve the integrin-mediated cellular uptake of the liposomes in vitro in human umbilical vein endothelial cells (HUVECs), and in vivo as evidenced by chicken chorioallantoic membrane angiogenesis (CAM) model. It also could enrich the liposome accumulation in C26 tumor. Interestingly, co-treatment with PLGba and pegylated liposomal doxorubicin (PLD, also known as Doxil ® ) had a synergistic and antagonistic antiproliferative effect on the C26 tumor cell line and the normal HUVEC, respectively. In C26 tumor bearing BALB/c mice, the PLGba and PLD combinatorial therapy improved the antitumor efficacy of the treatment as compared to those of single agents. This results have clear implications for cancer therapy.

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Section: Methodsmentioning

confidence: 99%

Liposomal formulation of Galbanic acid improved therapeutic efficacy of pegylated liposomal Doxorubicin in mouse colon carcinoma

Nik

Malaekeh‐Nikouei

Amin

et al. 2019

Sci Rep

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“…The antitumor effect of doxorubicin has been introduced for the selection of this compound in order to deal with a range of cancers, such as leukemia, lymphoma, and solid tumors in humans (3). However, the limiting factor in the use of doxorubicin in the treatment of cancer is its toxic effects on vital organs, such as the heart, kidneys, and liver (4,5).…”

Section: Doxorubicinmentioning

confidence: 99%

Protective effects of olive in renal failure; a review on current knowledge

et al. 2018

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Context: The pathogenesis of renal damage as a risk factor of renal failure can be due to oxidative stress resulting from an imbalance between the production of free radicals and antioxidants. Therefore, antioxidant therapy can be a good strategy to decrease the effects of such diseases. Hence, the aim of this review was to evaluate the protective effect of olive oil as an herb rich in antioxidant compounds on kidney damage in previous studies. Evidence Acquisitions: Present review is based on scrutinizing the contents of relevant papers searched in PubMed, Google Scholar, EBSCO, Embase, directory of open access journals (DOAJ), Web of Science and Scopus. Results: Numerous studies have introduced herbal treatments, being rich sources of antioxidants, as appropriate alternatives for several diseases, including renal damage, when considering the pathogenesis of the diseases. The olive has also been recommended as a plant that has different therapeutic effects, and its therapeutic effects on the kidneys are mentioned in several studies, including the reduction of renal damage parameters and an increase in the antioxidant power of enzymes in the body. Conclusions: Considering the numerous studies on animal models, particularly rats and renal cell lines, olive oil can be used as a reliable method for the treatment of various kidney damages. However, further studies are also recommended in humans.

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“…The PEG moiety limits the interactions of the micelles with reticuloendothelial systems and the low critical micelle concentration confers micellar stability in the circular system when they are diluted in blood following intravenous (i.v.) administration (Liu et al, ; Teymouri et al, ). The drug loading capacity of the polymeric micelle was much higher (∼10%) than the previously mentioned liposomes.…”

Section: Cellular and Molecular Targets Of Dimc Causing Cancer Cell Amentioning

confidence: 99%

“…This indicates that the issue of DiMC‐nanoparticulation still needs further investigation and improvement. As Dox and DiMC share ROS cellular alteration as one of their cellular features (Barenholz, ; Kunwar et al, ), their combined nanoparticles administration might provide a superior anti‐tumor activity with diminished side effect (Liu et al, ; Teymouri et al, ).…”

Section: Cellular and Molecular Targets Of Dimc Causing Cancer Cell Amentioning

confidence: 99%

Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential

Teymouri

Barati

Pirro

et al. 2017

Journal Cellular Physiology

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Dimethoxycurcumin (DiMC) is a synthetic analog of curcumin with superior inter-related pro-oxidant and anti-cancer activity, and metabolic stability. Numerous studies have shown that DiMC reserves the biologically beneficial features, including anti-inflammatory, anticarcinogenic, and cytoprotective properties, almost to the same extent as curcumin exhibits. DiMC lacks the phenolic-OH groups as opposed to curcumin, dimethoxycurcumin, and bis-demethoxycurcumin that all vary in the number of methoxy groups per molecule, and has drawn the attentions of researchers who attempted to discover the structureactivity relationship (SAR) of curcumin. In this regard, tetrahydrocurcumin (THC), the reduced and biologically inert metabolite of curcumin, denotes the significance of the conjugated α,β diketone moiety for the curcumin activity. DiMC exerts unique molecular activities compared to curcumin, including induction of androgen receptor (AR) degradation and suppression of the transcription factor activator protein-1 (AP-1). The enhanced AR degradation on DiMC treatment suggests it as a novel anticancer agent against resistant tumors with androgenic etiology. Further, DiMC might be a potential treatment for acne vulgaris. DiMC induces epigenetic alteration more effectively than curcumin, although both showed no direct DNA hypomethylating activity. Given the metabolic stability, nanoparticulation of DiMC is more promising for in vivo effectiveness. However, studies in this regard are still in its infancy. In the current review, we portray the various molecular and biological functions of DiMC reported so far. Whenever possible, the efficiency is compared with curcumin and the reasons for DiMC being more metabolically stable are elaborated. We also provide future perspective investigations with respect to varying DiMC-nanoparticles. K E Y W O R D Sandrogen, anti-oxidant, curcumin, cytoprotective, dimethoxycurcumin, pro-oxidant

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Tat peptide and hexadecylphosphocholine introduction into pegylated liposomal doxorubicin: An in vitro and in vivo study on drug cellular delivery, release, biodistribution and antitumor activity

Cited by 26 publications

References 31 publications

Liposomal formulation of Galbanic acid improved therapeutic efficacy of pegylated liposomal Doxorubicin in mouse colon carcinoma

Liposomal formulation of Galbanic acid improved therapeutic efficacy of pegylated liposomal Doxorubicin in mouse colon carcinoma

Protective effects of olive in renal failure; a review on current knowledge

Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential

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