Lasers have been widely used for tattoo removal, but the limited light penetration depth caused by high skin scattering property restricts the therapeutic outcome of deep tattoo. Skin optical clearing method, by introducing optical clearing agent (OCA) into skin, has shown some improvement in the e®ect of laser tattoo removal. In this study, the enhanced laser tattoo removal has been quantitatively assessed. OCA was applied to the skin of tattoo animal model and Q-switched Nd:YAG laser (1064 nm) irradiation was used to remove the tattoo. The skin evaluation instrument (Mexameter probe, MPA580) was applied to measure the content of tattoo pigment before and after laser treatment, and then the clearance rate of pigment was calculated. Further, Monte Carlo (MC) method was utilized to simulate the e®ect of skin optical clearing on light transmission in tattoo skin model. By comparing the pigment change of tattoo areas respectively treated with OCA plus laser and single laser, it was found that pigment clearance of the former tattoo area was increased by 1.5-fold. Further, the MC simulation veri¯ed that the reduced light scattering in skin could increase the e®ective dose of luminous°ux reaching to the deep tattoo regions. It can be concluded from both experiment and theoretical This is an Open Access article published by World Scienti¯c Publishing Company. It is distributed under the terms of the Creative Commons Attribution 3.0 (CC-BY) License. Further distribution of this work is permitted, provided the original work is properly cited. k Corresponding Authors. Vol. 8, No. 3 (2015) 1541007 (8 pages simulations that skin optical clearing technique could improve the outcome of laser tattoo removal, which should be bene¯cial for clinical laser tattoo removal and other laser pigment elimination.
Journal of Innovative Optical Health Sciences