2023
DOI: 10.1101/2023.02.19.528206
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Tau expression and phosphorylation in enteroendocrine cells

Abstract: There is mounting evidence to suggest that the gut-brain axis is involved in the development of Parkinson's disease (PD). In this regard, the enteroendocrine cells (EEC), which faces the gut lumen and are connected with both enteric neurons and glial cells have received growing attention. The recent observation showing that these cells express alpha-synuclein, a presynaptic neuronal protein genetically and neuropathologically linked to PD came to reinforce the assumption that EEC might be a key component of th… Show more

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(2 citation statements)
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“…Accumulating evidence suggest that α‐syn aggregates can spread from the brain to the periphery or from the gut to the brain, supporting a “dual‐hit” hypothesis of PD 177 . Moreover, recent studies have also reported that EECs, which are exposed to the gut lumen and are in close contact with both enteric neurons and glial cells, express both tau and α‐syn 45,178 . Due to their close anatomical connection with afferent nervous fibers, EECs might have a key role in the propagation of misfolded proteins form the gut to the brain, especially when subject to dysbiosis and ER stress 179,180 …”
Section: The Role Of Er Stress Along the Gut–brain Axismentioning
confidence: 97%
See 1 more Smart Citation
“…Accumulating evidence suggest that α‐syn aggregates can spread from the brain to the periphery or from the gut to the brain, supporting a “dual‐hit” hypothesis of PD 177 . Moreover, recent studies have also reported that EECs, which are exposed to the gut lumen and are in close contact with both enteric neurons and glial cells, express both tau and α‐syn 45,178 . Due to their close anatomical connection with afferent nervous fibers, EECs might have a key role in the propagation of misfolded proteins form the gut to the brain, especially when subject to dysbiosis and ER stress 179,180 …”
Section: The Role Of Er Stress Along the Gut–brain Axismentioning
confidence: 97%
“…177 Moreover, recent studies have also reported that EECs, which are exposed to the gut lumen and are in close contact with both enteric neurons and glial cells, express both tau and α-syn. 45,178 Due to their close anatomical connection with afferent nervous fibers, EECs might have a key role in the propagation of misfolded proteins form the gut to the brain, especially when subject to dysbiosis and ER stress. 179,180 Inflammation of the gastrointestinal tract is a possible starting point of α-syn pathology and transmission since it has been considered the main factor responsible for cell-to-cell transmission of α-syn oligomers along the vagus nerve.…”
Section: The Role Of Er S Tre Ss Along the G Ut-b R Ain A Xismentioning
confidence: 99%