Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

Moon, Phil‐Dong; Kim, Minho; Lim, Hyunsun; Oh, Hyun‐A; Nam, Sun‐Young; Han, Ning; Kim, Myong Jo; Jeong, Hyun‐Ja; Kim, Hyung-Min

doi:10.1002/biof.1213

Cited by 25 publications

(14 citation statements)

References 51 publications

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“…Exact mechanism for the upregulation of IGF-1 by taurine is unclear in fishes. However, GH secretion of animals was induced by taurine in previous studies (Collu et al 1978;Ikuyama et al 1988;Huxtable 1992;Moon et al 2015). Also, production of IGF-1 in gilthead sea bream (Sparus aurata) was enhanced by GH administration (Pérez-Sánchez et al 1994).…”

Section: Discussionmentioning

confidence: 95%

Effects of taurine supplementation in low fish meal diets for red seabream (Pagrus major) in low water temperature season

et al. 2019

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Background: Taurine is a conditional essential amino acid for fish. A study was conducted to investigate the compensating effect of supplemental taurine in diets for red seabream (Pagrus major) on impaired growth performance by fish meal (FM) replacement with soybean meal (SM) at low water temperature (14.15 ± 1.95°C). Methods: A FM-based diet was considered as a high FM diet and three other experimental diets were formulated to replace FM with SM by 20, 35, or 50% (HFM, SM20, SM35, or SM50, respectively) without taurine and other four diets were formulated by adding 1% taurine to the diets (HFM-T, SM20-T, SM35-T, or SM50-T, respectively). Triplicate groups of fish (108.9 ± 1.58 g/fish) were distributed into 24 polyvinyl circular tanks (215 L) with 20 fish per tank and fed one of the diets to satiation for 20 weeks. Results: Growth performance and feed utilization of red seabream were significantly improved by the dietary taurine supplementation. SM20-T and SM35-T diets increased fish growth that are comparable to HFM diet. Feed intake, feed conversion ratio, and protein efficiency ratio of fish fed SM20-T and SM35-T diets were not significantly different from those of HFM group. Dietary taurine supplementation in each FM replaced group numerically increased innate immunity of the fish. Lysozyme and superoxide dismutase activities were significantly decreased in fish fed SM35, SM50, and SM50-T diets compared to those of fish fed HFM diet while they were not significantly lower in SM20, SM20-T, SM35, and SM35-T groups. Glutathione peroxidase activity was significantly lower in fish group fed SM50 diet while SM50-T group did not significantly lower compared to that of HFM group. The relative expression level of hepatic IGF-1 mRNA was improved in fish fed taurine-supplemented diets compared to their respective SM diets. Conclusions: Growth performance and feed utilization of red seabream can be accelerated or restored by 1% taurine supplementation when they are fed high level of SM up to 35% in diets during low water temperature season.

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Section: Discussionmentioning

confidence: 95%

Effects of taurine supplementation in low fish meal diets for red seabream (Pagrus major) in low water temperature season

et al. 2019

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“…They suggested that the observed effect was conducted through the ERK2 signaling pathway. Moreover, Moon et al 23 observed that Tau over-expressed Insulin-like growth factor 1 (IGF-1) and serum level of IGF-1 through the phosphorylations of JAK2 and STAT5. They observed that these molecular changes enhance growth plate length, bone volume density (BV/TV), trabecular thickness (Tb.Th), and total porosity.…”

Section: Resultsmentioning

confidence: 99%

“…It is a sulfurated β-amino acid that is found in free form in animal sources 20 , 21 . It is documented that Tau is involved in calcium modulation, osmoregulation, antioxidation, membrane stabilization, neuromodulation, protein phosphorylation regulation 19 , 22 , 23 . Accordingly, in the current study, we aimed to combine the positive biological activities of electrospun (GNFs) and Tau with the structural features of the TIP-based scaffold to develop an innovative tissue engineering approach for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

A tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration

Samadian

Farzamfar

Vaez

et al. 2020

Sci Rep

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The focus of the current study was to develop a functional and bioactive scaffold through the combination of 3D polylactic acid (PLA)/polycaprolactone (PCL) with gelatin nanofibers (GNFs) and Taurine (Tau) for bone defect regeneration. GNFs were fabricated via electrospinning dispersed in PLA/PCL polymer solution, Tau with different concentrations was added, and the polymer solution converted into a 3D and porous scaffold via the thermally-induced phase separation technique. The characterization results showed that the scaffolds have interconnected pores with the porosity of up to 90%. Moreover, Tau increased the wettability and weight loss rate, while compromised the compressive strengths. The scaffolds were hemo- and cytocompatible and supported cell viability and proliferation. The in vivo studies showed that the defects treated with scaffolds filled with new bone. The computed tomography (CT) imaging and histopathological observation revealed that the PLA/PCL/Gel/Tau 10% provided the highest new bone formation, angiogenesis, and woven bone among the treatment groups. Our finding illustrated that the fabricated scaffold was able to regenerate bone within the defect and can be considered as the effective scaffold for bone tissue engineering application.

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“…In addition, it is well known that oyster meat is a high-quality marine food resource that contains several vitamins and minerals [ 2 ]. Numerous studies have reported that oysters and their bioactive peptides have pharmacological benefits including anti-oxidant [ 3 ], anti-microbial [ 4 ], osteogenic [ 5 , 6 ], anti-inflammatory [ 7 ], postprandial blood glucose control [ 8 ], and anti-coagulant properties [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats

Lee

Hwangbo

et al. 2020

Molecules

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Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulation and the proximal tibial growth plate. Therefore, in this study, we investigated the effect of FO oral administration on hepatic and serum growth regulator levels and the development of the proximal tibial growth plate in young Sprague-Dawley rats. Both oral administration of FO (FO 100, 100 mg/kg FO and FO 200, 200 mg/kg FO) and subcutaneous injection of recombinant human growth hormone (rhGH, 200 μg/kg of rhGH) for two weeks showed no toxicity. Circulating levels of growth hormone (GH) significantly increased in the FO 200 group. The expression and secretion of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were enhanced by FO administration. FO administration promoted the expression of bone morphogenic proteins IGF-1 and IGFBP-3 in the proximal tibial growth plate. This positive effect of FO resulted in incremental growth of the entire plate length by expanding the proliferating and hypertrophic zones in the proximal tibial growth plate. Collectively, our results suggested that oral administration of FO is beneficial for bone health, which may ultimately result in increased height.

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Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

Cited by 25 publications

References 51 publications

Effects of taurine supplementation in low fish meal diets for red seabream (Pagrus major) in low water temperature season

Effects of taurine supplementation in low fish meal diets for red seabream (Pagrus major) in low water temperature season

A tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration

Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats

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