2018
DOI: 10.1002/mnfr.201800569
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Taurine: A Regulator of Cellular Redox Homeostasis and Skeletal Muscle Function

Abstract: Taurine is a nonproteinogenic ß-aminosulfonic acid. Important dietary sources of taurine are fish and seafood. Taurine interacts with ion channels, stabilizes membranes, and regulates the cell volume. These actions confirm its high concentrations in excitable tissues like retina, neurons, and muscles. Retinal degeneration, cardiomyopathy, as well as skeletal muscle malfunction are evident in taurine-deficient phenotypes. There is evidence that taurine counteracts lipid peroxidation and increases cellular antio… Show more

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Cited by 124 publications
(132 citation statements)
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References 178 publications
(210 reference statements)
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“…This was associated with increased mRNA expression of antioxidant genes (Nrf2, HO-1, SOD, CAT, GPx) and decreased the oxidative damage index (MDA, ROS, PC, 8-OhdG) in chicken breast muscle [296] and expression of Nrf2, HO-1, SOD and GPx in chicken liver mitochondria due to the dietary probiotic [297]. Furthermore, there is a range of other nutrients upregulating Nrf2 expression in different poultry tissues, including carnitine [90], taurine [298] and silymarin [91].…”
Section: Other Nutrients and Probioticsmentioning
confidence: 99%
“…This was associated with increased mRNA expression of antioxidant genes (Nrf2, HO-1, SOD, CAT, GPx) and decreased the oxidative damage index (MDA, ROS, PC, 8-OhdG) in chicken breast muscle [296] and expression of Nrf2, HO-1, SOD and GPx in chicken liver mitochondria due to the dietary probiotic [297]. Furthermore, there is a range of other nutrients upregulating Nrf2 expression in different poultry tissues, including carnitine [90], taurine [298] and silymarin [91].…”
Section: Other Nutrients and Probioticsmentioning
confidence: 99%
“…Note that the distribution of PHT1/2 in tissues is species-specific in that human skeletal muscle expresses PHT1 but no PHT2, whereas mouse skeletal muscle expresses both PHT1 and PHT2 to osmoregulation; (6) a key component of nerve and muscle conduction networks; (7) a stimulator of neurological development; and (8) an inhibitory neurotransmitter in the central nervous system (CNS) (Schaffer and Kim 2018). Thus, taurine exerts beneficial effects on cardiovascular (including protection against ischemia-reperfusion injury, maintaining cell membrane structure, and reducing blood pressure), digestive, endocrine, immune, muscular, neurological, reproductive, and visual systems (Ito et al 2014;Shimada et al 2015;Seidel et al 2019). For example, taurine protects cells and tissues (brain) from the toxicity of reactive oxygen species (ROS), excess metals [e.g., nickel (Xu et al 2015) and manganese (Ahmadi et al 2018)], and ammonia (Jamshidzadeh et al 2017a) by maintaining the integrity of plasma and organelle (especially mitochondrion) membranes of the cell.…”
Section: Physiological Functions Of Taurinementioning
confidence: 99%
“…Growing evidence shows that taurine, carnosine, anserine, creatine and 4-hydroxyproline play crucial roles in protecting mammalian cells from oxidative stress and injury (Abplanalp et al 2019;Avgerinos et al 2018;Seidel et al 2019;Wu et al 2019). These results indicate that red meat provides not only high-quality protein for the growth of children but also functional amino acids, dipeptides and creatine for optimal human nutrition and health.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies indicate that taurine exerts important physiological functions in modulation of intracellular calcium concentration, ion channel function, glucose and lipid homeostasis, cellular redox homeostasis, and anti-antioxidant and anti-inflammatory responses [43,44,45]. In this study, significant changes were observed in the metabolic pathway of taurine and hypotaurine, and taurocholate was involved in this pathway.…”
Section: Discussionmentioning
confidence: 52%