Taurine abated subacute dichlorvos toxicity

Akande, Motunrayo Ganiyat; Ahmed, Usman

doi:10.1016/j.toxrep.2017.08.001

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…Oxidative stress is a pathological condition caused by the disparity between the development and removal of reactive oxygen species (ROS) derived from free radicals and the potential of a biological system to get rid of the reactive intermediates and return the system to its regular state [38,39]. Oxidative stress causes base damage by the formation of ROS such as O − 2 (superoxide radical), OH −1…”

Section: Resultsmentioning

confidence: 99%

“…No visible lesions seen Journal of Food Quality (hydroxyl radical), and H 2 O 2 hydrogen peroxide in addition to fragmentation of the genetic material, the DNA [38]. Superoxide dismutase, catalase, and glutathione peroxidase, as well as nonenzymatic compounds such as tocopherol ascorbic acid and glutathione, give protection to cells against oxidative stress by reducing free radical concentrations [39,40].…”

Section: Concentrationmentioning

confidence: 99%

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Biochemical and Histopathological Studies of Key Tissues in Healthy Male Wistar Rats Fed on African Yam Bean Seed and Tuber Meals

Ojuederie

Ajiboye

Babalola

2020

Journal of Food Quality

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Food insecurity and malnutrition are currently major issues affecting most developing countries, especially on the African continent. To mitigate this effect, focus is being given to orphan or underutilized crops with immense potentials to boost food and nutrition security in Africa, such as the African yam bean (AYB) Sphenostylis stenocarpa. The effect of AYB seed and tuber meals on the tissues of the kidney, liver, and testis of healthy male Wistar rats were investigated in this study. Four accessions of AYB were used for this study, TSs 107, TSs 140, AYB 45, and AYB 57. Thirty rats were randomly assigned into five groups (n = 6). Group I was fed on standard pelletized rat chow (control), Group II fed on 50% seed meal, Group III fed on 100% seed meal, Group IV fed on 50% tuber meal, and Group-V fed on 100% tuber meal. At the end of the treatments, the animals were sacrificed after 72 h under light ether anesthesia, and biochemical and histopathological analyses were conducted on the tissues. Phytate concentration was higher in the seeds (TSs140 (550 mg 100g−1), AYB45 (460 mg 100g−1), and AYB57 (485 mg 100g−1)) compared to the tubers (TSs140 (14.8 mg 100g−1), AYB 45 (275 mg 100g−1), and AYB57 (240 mg 100g−1)). The consumption of 100% unprocessed AYB seeds caused liver and kidney damage in rats due to increased levels of aspartate aminotransferase (5.04 ± 1.62 U L−I), alanine aminotransferase (8.46 ± 2.43 U L−I), and lipid peroxidation (0.27 ± 0.02-unit mg−1protein). AYB tubers were innocuous to Wistar rats investigated. Good processing of AYB seeds is required for safe consumption by humans and livestock. This study has shown that tubers of AYB are safe for human consumption and should be utilized in meals as it contains fewer antinutrients and had no significant effect on the tissues examined in Wistar rats.

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Section: Resultsmentioning

confidence: 99%

Section: Concentrationmentioning

confidence: 99%

Biochemical and Histopathological Studies of Key Tissues in Healthy Male Wistar Rats Fed on African Yam Bean Seed and Tuber Meals

Ojuederie

Ajiboye

Babalola

2020

Journal of Food Quality

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“…The protective effects of Tau on the antioxidant systems of the body are also shown in pesticide toxicity (methiocarb; [ 342 ] and lambda-cyhalothrin: [ 343 ]) and insecticide-related toxicity (permethrin: [ 344 ], endosulfan: [ 345 ], dichlorvos: [ 346 ]). Tau showed high protective efficacy against typical prooxidants such as butyl hydroperoxide [ 347 ], peroxynitrite [ 348 ], H 2 O 2 [ 349 ] and ozone [ 350 ].…”

Section: Antioxidant Properties Of Taumentioning

confidence: 99%

Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models

2021

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Natural antioxidants have received tremendous attention over the last 3 decades. At the same time, the attitude to free radicals is slowly changing, and their signalling role in adaptation to stress has recently received a lot of attention. Among many different antioxidants in the body, taurine (Tau), a sulphur-containing non-proteinogenic β-amino acid, is shown to have a special place as an important natural modulator of the antioxidant defence networks. Indeed, Tau is synthesised in most mammals and birds, and the Tau requirement is met by both synthesis and food/feed supply. From the analysis of recent data, it could be concluded that the direct antioxidant effect of Tau due to scavenging free radicals is limited and could be expected only in a few mammalian/avian tissues (e.g., heart and eye) with comparatively high (>15–20 mM) Tau concentrations. The stabilising effects of Tau on mitochondria, a prime site of free radical formation, are characterised and deserve more attention. Tau deficiency has been shown to compromise the electron transport chain in mitochondria and significantly increase free radical production. It seems likely that by maintaining the optimal Tau status of mitochondria, it is possible to control free radical production. Tau’s antioxidant protective action is of great importance in various stress conditions in human life, and is related to commercial animal and poultry production. In various in vitro and in vivo toxicological models, Tau showed AO protective effects. The membrane-stabilizing effects, inhibiting effects on ROS-producing enzymes, as well as the indirect AO effects of Tau via redox balance maintenance associated with the modulation of various transcription factors (e.g., Nrf2 and NF-κB) and vitagenes could also contribute to its protective action in stress conditions, and thus deserve more attention.

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“…It belongs to the organophosphate (OP) contact insecticide family. It has been widely used to protect greenhouse plants, fruits, and vegetables from mushroom flies, aphids, spiders, mites, caterpillars, thrips, and white flies, as well as to control sucking, chewing, and boring insects and spider mites on a very wide range of crops [ [1] , [2] , [3] , [4] , [5] , [6] ]. Both domestic and agricultural fields widely use dichlorvos, a highly effective and low-toxic insecticide, to enhance global agricultural production, maintain hygienic conditions [ [7] , [8] , [9] , [10] , [11] , [12] ], and treat livestock infections [ [13] , [14] , [15] ].…”

Section: Introductionmentioning

confidence: 99%

Synthesized novel chromogenic reagent and sensor: Detection and identification of dichlorvos

Gedam,

Katiya,

Dhonde

et al. 2024

Heliyon

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Taurine abated subacute dichlorvos toxicity

Abstract: Graphical abstract

Cited by 9 publications

References 25 publications

Biochemical and Histopathological Studies of Key Tissues in Healthy Male Wistar Rats Fed on African Yam Bean Seed and Tuber Meals

Biochemical and Histopathological Studies of Key Tissues in Healthy Male Wistar Rats Fed on African Yam Bean Seed and Tuber Meals

Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models

Synthesized novel chromogenic reagent and sensor: Detection and identification of dichlorvos

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