Taurine acts on presynaptic autoreceptors for GABA in the cerebellum: Effects on Ca2+ influx and GABA release.

Namima, Misako; Okamoto, Koichi; Sakai, Yutaka

doi:10.1254/jjp.32.746

Cited by 12 publications

(7 citation statements)

References 15 publications

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“…Knowing that glycine and taurine are important amino acid neurotransmitters that are known to modulate GABA neurochemistry (Namima et al, 1982; Hernandes and Troncone, 2009), it was logical that we measure them in the dialysate too. We found that GAT function is attenuated by Mn exposure, and that the resulting increase in GABA EC alters taurine but not glycine homeostasis.…”

Section: Discussionmentioning

confidence: 99%

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Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats

et al. 2010

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Manganese (Mn) accumulation in the brain has been shown to alter the neurochemistry of the basal ganglia. Mn-induced alterations in dopamine biology are fairly well understood, but recently more evidence has emerged characterizing the role of γ-aminobutyric acid (GABA) in this dysfunction. The purpose of this study was to determine if the previously observed Mn-induced increase in extracellular GABA (GABA EC ) was due to altered GABA transporter (GAT) function, and whether Mn perturbs other amino acid neurotransmitters, namely taurine and glycine (known modulators of GABA). Extracellular GABA, taurine, and glycine concentrations were collected from the striatum of control (CN) or Mn-exposed Sprague-Dawley rats using in vivo microdialysis, and the GAT inhibitor nipecotic acid (NA) was used to probe GAT function. Tissue and extracellular Mn levels were significantly increased, and the Fe:Mn ratio was decreased 36-fold in the extracellular space due to Mn exposure. NA led to a 2-fold increase in GABA EC of CNs, a response that was attenuated by Mn. Taurine responded inversely to GABA, and a novel 10-fold increase in taurine was observed after the removal of NA in CNs. Mn blunted this response and nearly abolished extracellular taurine throughout collection. Striatal taurine transporter (Slc6a6) mRNA levels were significantly increased with Mn exposure, and Mn significantly increased 3 H-Taurine uptake after 3-minute exposure in primary rat astrocytes. These data suggest that Mn increases GABA EC by inhibiting the function of GAT, and that perturbed taurine homeostasis potentially impacts neural function by jeopardizing the osmoregulatory and neuromodulatory functions of taurine in the brain.

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Section: Discussionmentioning

confidence: 99%

“…It is also possible that Mn may alter some sort of feedback mechanism such as an autoreceptor (e.g., GABA B or GABA A ). Being that taurine is a known modulator of GABA receptors (del Olmo et al, 2000; Kamisaki et al, 1993; Jia et al, 2008; Namima et al, 1982, 1983), perturbations in taurine biology may play a role in GABA homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats

et al. 2010

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“…As in the present study, Tau concentrations in the globus pallidus of rats measured in vivo by NMR spectroscopy (Zwingmann et al, 2007) after MnCl 2 infusion demonstrated significant decreases compared with control rats. Taurine is also an important neurotransmitter known to modulate GABA neurochemistry (Namima et al, 1982(Namima et al, , 1983 and share GABA transporters in the brain. Here, due to Mn 2 + exposure taurine responded inversely to GABA.…”

Section: Spectroscopic Analysis Of the Hypothalamus Energy Metabolismmentioning

confidence: 99%

Effect of Manganese Chloride on the Neurochemical Profile of the Rat Hypothalamus

Just

Cudalbu

Lei

et al. 2011

J Cereb Blood Flow Metab

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Manganese (Mn 2 + )-enhanced magnetic resonance imaging studies of the neuronal pathways of the hypothalamus showed that information about the regulation of food intake and energy balance circulate through specific hypothalamic nuclei. The dehydration-induced anorexia (DIA) model demonstrated to be appropriate for studying the hypothalamus with Mn 2 + -enhanced magnetic resonance imaging. Manganese is involved in the normal functioning of a variety of physiological processes and is associated with enzymes contributing to neurotransmitter synthesis and metabolism. It also induces psychiatric and motor disturbances. The molecular mechanisms by which Mn 2 + produces alterations of the hypothalamic physiological processes are not well understood.1 H-magnetic resonance spectroscopy measurements of the rodent hypothalamus are challenging due to the distant location of the hypothalamus resulting in limited measurement sensitivity. The present study proposed to investigate the effects of Mn 2 + on the neurochemical profile of the hypothalamus in normal, DIA, and overnight fasted female rats at 14.1 T. Results provide evidence that c-aminobutyric acid has an essential role in the maintenance of energy homeostasis in the hypothalamus but is not condition specific. On the contrary, glutamine, glutamate, and taurine appear to respond more accurately to Mn 2 + exposure. An increase in glutamine levels could also be a characteristic response of the hypothalamus to DIA.

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“…Paying attention to a neuromodulatory role for taurine, especially its interaction with other transmitter candidates, presynaptically this amino acid has been shown to influence the release of transmitter candidates, L glutamate (L-glu), r-aminobutyric acid (GABA), noradrenaline and acetyl choline (1)(2)(3). On the other hand, many reports have provided evidence for the postsynaptic actions of taurine such as the increase of membrane conductance (4,5), the decrease of the firing rate (6) and the reduction of synaptic potential induced by electrical stimulation (7).…”

mentioning

confidence: 99%

Effect of taurine on depolarizations induced by L-glutamate and other excitatory amino acids in the isolated spinal cord of the frog.

1983

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Taurine acts on presynaptic autoreceptors for GABA in the cerebellum: Effects on Ca2+ influx and GABA release.

Cited by 12 publications

References 15 publications

Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats

Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats

Effect of Manganese Chloride on the Neurochemical Profile of the Rat Hypothalamus

Effect of taurine on depolarizations induced by L-glutamate and other excitatory amino acids in the isolated spinal cord of the frog.

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