Taurine and
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            -acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice

García-Serrano, Alba M.; Vieira, Joao P P; Fleischhart, Veronika; Duarte, João M. N.

doi:10.1080/1028415x.2022.2131062

Cited by 19 publications

(33 citation statements)

References 48 publications

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“…In sum, despite previous reports on memory impairment in diet-induced obesity models (Lizarbe et al, 2019;Garcia-Serrano, Mohr et al, 2022;Garcia-Serrano, Vieira et al, 2022), mice under treatment with culture medium or bacteria do not show HFD-induced memory impairment in the present study.…”

Section: Behaviour Characterizationcontrasting

confidence: 99%

“…For that, we exposed mice to a high-fat diet (HFD), which is a well-characterized model of obesity with metabolic syndrome (Soares et al, 2018) and memory impairment (Garcia-Serrano, Vieira et al, 2022), and treated them with any of these four bacterial strains for two months. Afterwards, we evaluated metabolic health, and brain function and behaviour phenotypes such as memory, anxiety and depression.…”

Section: Introductionmentioning

confidence: 99%

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Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behavior in an obesity mouse model

Garcia-Serrano,

Skoug,

Axling

et al. 2023

Preprint

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Obesity is a risk factor for cardio-metabolic and neurological disease. The contribution of gut microbiota to derangements of the gut-brain axis in the context of obesity has been acknowledged, particularly through physiology modulation by short-chain fatty acids (SCFAs). Thus, probiotic interventions and administration of SCFAs have been employed with the purpose of alleviating symptoms in both metabolic and neurological disease. We have tested the effects of four butyrate-producing bacteria from the Lachnospiraceae family on the development of metabolic syndrome and behavioural alterations in a mouse model of diet-induced obesity. Male mice were fed either a high-fat diet (HFD) or an ingredient-matched control diet for 2 months, and bacteria cultures or culture medium were given by gavage to HFD-fed mice every second day. Assessment of the mice through a battery of metabolic and behaviour tests revealed that one of the administered bacteria affords some degree of protection against the development of obesity and its complications.

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Section: Behaviour Characterizationcontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behavior in an obesity mouse model

Garcia-Serrano,

Skoug,

Axling

et al. 2023

Preprint

Self Cite

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“…In a rat model of high-fat diet-induced obesity, NAC treatments improve glycemia and peripheral insulin resistance and reduce the oxidative stress/neuroinflammation/inflammasome activation axis in the cerebral cortex [ 132 ]. In a mouse model of obesity, NAC prevents hippocampal alterations and memory impairment [ 133 ]. In older humans, GlyNAC (a combination of glycine and N-acetylcysteine NAC) supplementation for 24 weeks decreases oxidative stress and mitochondrial dysfunction; reduces inflammation, insulin resistance, and endothelial dysfunction; and improves cognition [ 134 ].…”

Section: Obesity Induces Cognitive Declinementioning

confidence: 99%

Obesity-Induced Brain Neuroinflammatory and Mitochondrial Changes

Schmitt

Gaspar

2023

Metabolites

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Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is caused by an imbalance in energy homeostasis resulting from increased caloric intake associated with a sedentary lifestyle. However, the entire physiopathology linking obesity with neurodegeneration and cognitive decline has not yet been elucidated. During the progression of obesity, adipose tissue undergoes immune, metabolic, and functional changes that induce chronic low-grade inflammation. It has been proposed that inflammatory processes may participate in both the peripheral disorders and brain disorders associated with obesity, including the development of cognitive deficits. In addition, mitochondrial dysfunction is related to inflammation and oxidative stress, causing cellular oxidative damage. Preclinical and clinical studies of obesity and metabolic disorders have demonstrated mitochondrial brain dysfunction. Since neuronal cells have a high energy demand and mitochondria play an important role in maintaining a constant energy supply, impairments in mitochondrial activity lead to neuronal damage and dysfunction and, consequently, to neurotoxicity. In this review, we highlight the effect of obesity and high-fat diet consumption on brain neuroinflammation and mitochondrial changes as a link between metabolic dysfunction and cognitive decline.

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“…Male C57BL/6J mice (8-weeks old; Taconic, Skensved, Denmark) were group-housed on a 12h light-dark cycle in enriched cages with access to food and water ad libitum and, after acclimatization, were fed high-fat (HFD, 60% fat kcal) or control diets (CD, 10% fat kcal) (Research Diets, New Brunswick, NJ-USA) as previously described [11]. Experimenters were blinded to group allocation during sample processing and data analysis.…”

Section: Mouse Studymentioning

confidence: 99%

Plasma Galectin-4 Levels are Increased after Stroke in Mice and Humans

Vieira¹,

Jujić²,

Matušková³

et al. 2023

Preprint

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Background Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with increased risk of coronary artery disease, but data regarding possible associations with stroke are lacking. Methods We tested Gal-4 association with prevalent stroke in a population-based cohort, and whether Gal-4 increases after ischemic stroke in mice fed a high-fat diet (HFD). Results Gal-4 was higher in subjects with compared to without prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01-2.30; p=0.048) adjusted for age, sex and covariates of cardiometabolic health. Plasma Gal-4 increased after stroke in both controls and HFD-fed mice, but HFD exposure was devoid of impact in Gal-4 levels. Conclusions This study demonstrates higher plasma Gal-4 levels in both a stroke mouse model and individuals with prevalent stroke.

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Taurine and N -acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice

Cited by 19 publications

References 48 publications

Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behavior in an obesity mouse model

Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behavior in an obesity mouse model

Obesity-Induced Brain Neuroinflammatory and Mitochondrial Changes

Plasma Galectin-4 Levels are Increased after Stroke in Mice and Humans

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