“…The ability of taurine to regulate ion channels [131,132], modulate Ca 2+ homeostasis [133][134][135], and enhance endothelial function [136][137][138][139][140] may contribute to its antihypertensive properties. Additionally, its antioxidant activity [54,126,[141][142][143] may help protect blood vessels from oxidative stress, further contributing to its beneficial effects on blood pressure regulation.…”
Taurine, a naturally occurring sulfur-containing amino acid, has attracted significant attention in recent years due to its potential health benefits. Found in various foods and often used in energy drinks and supplements, taurine has been studied extensively to understand its impact on human physiology. Determining its exact functional roles represents a complex and multifaceted topic. We provide an overview of the scientific literature and present an analysis of the effects of taurine on various aspects of human health, focusing on aging and cardiovascular pathophysiology, but also including athletic performance, metabolic regulation, and neurological function. Additionally, our report summarizes the current recommendations for taurine intake and addresses potential safety concerns. Evidence from both human and animal studies indicates that taurine may have beneficial cardiovascular effects, including blood pressure regulation, improved cardiac fitness, and enhanced vascular health. Its mechanisms of action and antioxidant properties make it also an intriguing candidate for potential anti-aging strategies.
“…The ability of taurine to regulate ion channels [131,132], modulate Ca 2+ homeostasis [133][134][135], and enhance endothelial function [136][137][138][139][140] may contribute to its antihypertensive properties. Additionally, its antioxidant activity [54,126,[141][142][143] may help protect blood vessels from oxidative stress, further contributing to its beneficial effects on blood pressure regulation.…”
Taurine, a naturally occurring sulfur-containing amino acid, has attracted significant attention in recent years due to its potential health benefits. Found in various foods and often used in energy drinks and supplements, taurine has been studied extensively to understand its impact on human physiology. Determining its exact functional roles represents a complex and multifaceted topic. We provide an overview of the scientific literature and present an analysis of the effects of taurine on various aspects of human health, focusing on aging and cardiovascular pathophysiology, but also including athletic performance, metabolic regulation, and neurological function. Additionally, our report summarizes the current recommendations for taurine intake and addresses potential safety concerns. Evidence from both human and animal studies indicates that taurine may have beneficial cardiovascular effects, including blood pressure regulation, improved cardiac fitness, and enhanced vascular health. Its mechanisms of action and antioxidant properties make it also an intriguing candidate for potential anti-aging strategies.
“…Taurine is an endogenous sulfur‐containing amino acid usually synthesized in the liver via the cysteine sulfonic acid pathway 24 . Human beings obtain taurine via dietary sources (e.g., meat and fish) and pharmaceutical supplement 25,26 . Taurine is a safe and well tolerated chemoprotective agent in humans 27,28 .…”
Section: Introductionmentioning
confidence: 99%
“…24 Human beings obtain taurine via dietary sources (e.g., meat and fish) and pharmaceutical supplement. 25,26 Taurine is a safe and well tolerated chemoprotective agent in humans. 27,28 It is interesting to know that taurine is found in the vascular endothelial cells, Leydig cells and interstitial cells of the testis, 29 where they enhance reproductive function.…”
The broad contemporary applications of silver nanoparticles (AgNPs) have been associated with various toxicities including reproductive toxicity. Taurine is well acknowledged for its potent pharmacological role in numerous disease models and chemically‐mediated toxicity. We investigated the effect of taurine on AgNPs‐induced reproductive toxicity in male rats. The animals were intraperitoneally injected with AgNPs (200 μg/kg) alone or co‐administered with taurine at 50 and 100 mg/kg for 21 successive days. Exogenous taurine administration significantly abated AgNPs‐induced oxidative injury by decreasing the levels of oxidative stress indices while boosting antioxidant enzymes activities and glutathione level in the hypothalamus, testes and epididymis of exposed animals. Taurine administration alleviated AgNPs‐induced inflammatory response and caspase‐3 activity, an apoptotic biomarker. Moreover, taurine significantly improved spermiogram, reproductive hormones and the marker enzymes of testicular function in AgNPs‐treated animals. The ameliorative effect of taurine on pathological lesions induced by AgNPs in the exposed animals was substantiated by histopathological data. This study provides the first mechanistic evidence that taurine supplementation affords therapeutic effect against reproductive dysfunction associated with AgNPs exposure in male rats.
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