Taurine et acides amin?s dans la r?tine des animaux

Kubícek, R; Dolenek, A

doi:10.1016/s0021-9673(00)93422-8

Cited by 40 publications

(2 citation statements)

References 3 publications

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“…The retina contains an abundant amount of taurine and in some animal species the taurine level is higher in the retina than in other tissues (2). Within the retina, taurine appears to be concentrated in the photoreceptor layer particularly in photoreceptor inner segments and synaptic terminals (3,4,5,6).…”

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confidence: 99%

Taurine in Gerbil Retina: Changes During Ischemia Reperfusion/Insult (I.R.I.) and Aging

Delbarre¹,

Delbarre²,

Calinon³

1996

Journal of Ocular Pharmacology and Therapeutics

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The retina contains a high amount of taurine which suggests a role in retinal function. The mongolian gerbil is well studied in stroke because of its incomplete circle of Willis. Two groups of gerbils were used: one served as control and the other was subjected to unilateral left carotid occlusion during 30 minutes, followed by 60 minutes of reperfusion. Gerbils were selected by ocular fundus and only sensitive gerbils were retained for the experimentation. We studied the level of taurine in gerbil retina of different ages: 3, 9, 15 and 24 months old (sham operated and ischemic groups). Level of taurine was determined by HPLC/electrochemical method. Compared to sham operated groups, level of taurine was significantly increased in ischemic groups for all ages studied. In the sham operated groups, level of taurine was low at birth, reached a plateau, and then decreased with aging. In the ischemic groups, level of taurine regularly increased from 3 to 24 months of age. With comparison evaluated for each age (modification ischemic versus sham operated groups expressed in percentage), level of taurine was quite equal at 3 and 9 months of age, but increased in 15 and 24 months old gerbils.

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Taurine in Gerbil Retina: Changes During Ischemia Reperfusion/Insult (I.R.I.) and Aging

Delbarre¹,

Delbarre²,

Calinon³

1996

Journal of Ocular Pharmacology and Therapeutics

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“…The concentration of taurine in the retina is one of the highest found in animal tissues (12-45 mM) (Kubicek andDolenk, 1958: Pasantes-Morales et al, 1972;Orr et al, 1976). In spite of these strikingly high levels, the role of taurine in retinal function is still unknown.…”

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confidence: 99%

Light‐Stimulated Release of Taurine from Retinas of Kainic Acid‐Treated Chicks

Pasantes‐Morales

Quesada

Cárabez

1981

Journal of Neurochemistry

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The light-stimulated release of [3H]taurine from chick retina was studied in chicks intraocularly injected with kainic acid (60 nmol). This treatment produced a loss of more than 80% of the inner nuclear and the inner synaptic layers, sparing the outer retinal layers. Concomitantly, the treatment produced a marked decrease of endogenous GABA and glycine but not of taurine. The activity of glutamate decarboxylase was also markedly decreased in the kainic acid-treated retinas. The release of [3H]taurine, either spontaneous or stimulated by light, was unaffected by the treatment. These results suggest that the light-stimulated efflux of taurine occurs from the retinal layers which are not affected by the kainic acid treatment.

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Uptake, release, and binding of taurine in degenerated rat retinas

Salceda

Pasantes‐Morales

1982

J of Neuroscience Research

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High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor layer (IAM). MSG treatment decreased GABA uptake by more than 60%. Also, the potassium-stimulated release of this amino acid was markedly diminished (90%) in retinas lesioned by MSG. MSG treatment decreased 3H-GABA binding by 45%. Uptake, release or binding of GABA were unaffected by IAM-treatment. Taurine uptake was reduced by a similar degree by both MSG and IAM treatment, 57% and 38% respectively. Potassium-stimulated release of taurine was unchanged by MSG and 50% reduced by IAM. Both treatments reduced the spontaneous release of endogenous taurine. Binding of taurine to receptors in retinal membranes was practically unaffected by any of the treatments utilized. These results are consistent with a neurotransmitter action of GABA at the inner retinal layers, while they do not support a major role for taurine as a synaptic transmitter in retina.

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Taurine et acides amin?s dans la r?tine des animaux

Cited by 40 publications

References 3 publications

Taurine in Gerbil Retina: Changes During Ischemia Reperfusion/Insult (I.R.I.) and Aging

Taurine in Gerbil Retina: Changes During Ischemia Reperfusion/Insult (I.R.I.) and Aging

Light‐Stimulated Release of Taurine from Retinas of Kainic Acid‐Treated Chicks

Uptake, release, and binding of taurine in degenerated rat retinas

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