Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms

Mousavi, Khadijeh; Niknahad, Hossein; Mostofi, Amin Ghalamfarsa; Mohammadi, Hamidreza; Azarpira, Negar; Ommati, Mohammad Mehdi; Heidari, Reza

doi:10.5114/ceh.2020.99513

Cited by 33 publications

(26 citation statements)

References 125 publications

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“…In the same context, it has been mentioned that an important problem of cirrhosis is the heart injury, which can be assimilated with the use of bile duct ligated (BDL) animals. When taurine is administered to BDL animals for 42 consecutive days, it can rescue heart injury, by restoring mitochondrial function in the myocardium of animals ( 152 ). Taurine can ameliorate heart failure, by increasing energy expenditure (NAD + /NADH) and by interfering with acetylation of p53 transcription factor ( 153 ).…”

Section: The Anti-oxidant Efficacy Of Taurine Against Cardiac- Associmentioning

confidence: 99%

Protective role of taurine against oxidative stress (Review)

et al. 2021

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Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuroassociated disorders, hepatic cirrhosis, cardiac dysfunction and ischemia/reperfusion are examples of some injuries that are linked with oxidative stress. The present review gives a comprehensive description of all the underlying mechanisms of taurine, with the aim to explain its anti-oxidant actions. Taurine is regarded as a cytoprotective molecule due to its ability to sustain normal electron transport chain, maintain glutathione stores, upregulate anti-oxidant responses, increase membrane stability, eliminate inflammation and prevent calcium accumulation. In parallel, the synergistic effect of taurine with other potential therapeutic modalities in multiple disorders are highlighted. Apart from the results derived from research findings, the current review bridges the gap between bench and bedside, providing mechanistic insights into the biological activity of taurine that supports its potential therapeutic efficacy in clinic. In the future, further clinical studies are required to support the ameliorative effect of taurine against oxidative stress. Contents1. Introduction 2. The role of taurine in homeostasis 3. The role of taurine against oxidative stress and its underlying molecular mechanisms 4. The beneficial effect of taurine against neuro-associated disorders 5. The anti-oxidant efficacy of taurine against cardiacassociated oxidative stress 6. The regulatory importance of taurine in ischemia and reperfusion 7. The anti-oxidant efficacy of taurine against muscle-associated disorders 8. The anti-oxidant efficacy of taurine against hepatic-associated stress 9. The anti-oxidant properties of taurine in various toxicmediated insults 10. Conclusions

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Section: The Anti-oxidant Efficacy Of Taurine Against Cardiac- Associmentioning

confidence: 99%

Protective role of taurine against oxidative stress (Review)

et al. 2021

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“…Interestingly, in TAU transporter knockout models, ultrastructural changes in cardiomyocytes' mitochondria have been detected [7]. Recently we found that TAU could significantly improve mitochondrial function and blunted oxidative stress in the heart tissue of cirrhotic animals [178]. Moreover, it has been repeatedly reported that TAU could normalize various types of arrhythmia [179].…”

Section: Discussionmentioning

confidence: 99%

Cellular and mitochondrial taurine depletion in bile duct ligated rats: a justification for taurine supplementation in cholestasis/cirrhosis

Najibi¹,

Rezaei²,

Manthari³

et al. 2022

ceh

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Taurine (TAU) is a free amino acid abundant in the human body. Various physiological roles have been attributed to TAU. At the subcellular level, mitochondria are the primary targets for TAU function. Meanwhile, it has been found that TAU depletion is associated with severe pathologies. Cholestasis is a severe clinical complication that can progress to liver fibrosis, cirrhosis, and hepatic failure. Bile duct ligation (BDL) is a reliable model for assessing cholestasis/cirrhosis and related complications. The current study was designed to investigate the effects of cholestasis/cirrhosis on tissue and mitochondrial TAU reservoirs. Cholestatic rats were monitored (14 and 42 days after BDL surgery), and TAU levels were assessed in various tissues and isolated mitochondria. There was a significant decrease in TAU in the brain, heart, liver, kidney, skeletal muscle, intestine, lung, testis, and ovary of the BDL animals (14 and 42 days after surgery). Mitochondrial levels of TAU were also significantly depleted in BDL animals. Tissue and mitochondrial TAU levels in cirrhotic animals (42 days after the BDL operation) were substantially lower than those in the cholestatic rats (14 days after BDL surgery). These data indicate an essential role for tissue and mitochondrial TAU in preventing organ injury induced by cholestasis/cirrhosis and could justify TAU supplementation for therapeutic purposes.

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“…Total antioxidant capacity of testicular tissue, LCs, and sperm specimens was measured using the FRAP assay ( 72 – 74 ). Briefly, the working FRAP mixture was freshly prepared by mixing 25 mL of acetate buffer (300 mmol/L, pH = 3.6), 2.5 mL of TPTZ (2, 4, 6-tripyridyl-s-triazine, 10 mmol/L in 40 mmol/L hydrochloric acid), and 2.5 mL of ferric chloride (20 mmol/L).…”

Section: Methodsmentioning

confidence: 99%

The Role of Mitochondrial Impairment and Oxidative Stress in the Pathogenesis of Lithium-Induced Reproductive Toxicity in Male Mice

et al. 2021

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Lithium (Li+) is prescribed against a wide range of neurological disorders. Besides its excellent therapeutic properties, there are several adverse effects associated with Li+. The impact of Li+ on renal function and diabetes insipidus is the most common adverse effect of this drug. On the other hand, infertility and decreased libido is another complication associated with Li+. It has been found that sperm indices of functionality, as well as libido, is significantly reduced in Li+-treated men. These adverse effects might lead to drug incompliance and the cessation of drug therapy. Hence, the main aims of the current study were to illustrate the mechanisms of adverse effects of Li+ on the testis tissue, spermatogenesis process, and hormonal changes in two experimental models. In the in vitro experiments, Leydig cells (LCs) were isolated from healthy mice, cultured, and exposed to increasing concentrations of Li+ (0, 10, 50, and 100 ppm). In the in vivo section of the current study, mice were treated with Li+ (0, 10, 50, and 100 ppm, in drinking water) for five consecutive weeks. Testis and sperm samples were collected and assessed. A significant sign of cytotoxicity (LDH release and MTT assay), along with disrupted testosterone biosynthesis, impaired mitochondrial indices (ATP level and mitochondrial depolarization), and increased biomarkers of oxidative stress were detected in LCs exposed to Li+. On the other hand, a significant increase in serum and testis Li+ levels were detected in drug-treated mice. Moreover, ROS formation, LPO, protein carbonylation, and increased oxidized glutathione (GSSG) were detected in both testis tissue and sperm specimens of Li+-treated mice. Several sperm anomalies were also detected in Li+-treated animals. On the other hand, sperm mitochondrial indices (mitochondrial dehydrogenases activity and ATP levels) were significantly decreased in drug-treated groups where mitochondrial depolarization was increased dose-dependently. Altogether, these data mention oxidative stress and mitochondrial impairment as pivotal mechanisms involved in Li+-induced reproductive toxicity. Therefore, based on our previous publications in this area, therapeutic options, including compounds with high antioxidant properties that target these points might find a clinical value in ameliorating Li+-induced adverse effects on the male reproductive system.

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Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms

Cited by 33 publications

References 125 publications

Protective role of taurine against oxidative stress (Review)

Protective role of taurine against oxidative stress (Review)

Cellular and mitochondrial taurine depletion in bile duct ligated rats: a justification for taurine supplementation in cholestasis/cirrhosis

The Role of Mitochondrial Impairment and Oxidative Stress in the Pathogenesis of Lithium-Induced Reproductive Toxicity in Male Mice

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