2024
DOI: 10.1128/iai.00224-24
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Taurine modulates host cell responses to Helicobacter pylori VacA toxin

Mandy D. Westland,
Alexandra C. Schrimpe-Rutledge,
Simona G. Codreanu
et al.

Abstract: Colonization of the human stomach with Helicobacter pylori strains producing active forms of the secreted toxin VacA is associated with an increased risk of peptic ulcer disease and gastric cancer, compared with colonization with strains producing hypoactive forms of VacA. Previous studies have shown that active s1m1 forms of VacA cause cell vacuolation and mitochondrial dysfunction. In this study, we sought to define the cellular metabolic consequences of VacA intoxication. Untarge… Show more

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