Taurine Prevents Ibuprofen-Induced Gastric Mucosal Lesions and Influences Endogenous Antioxidant Status of Stomach in Rats

Balasubramanian, T.; Somasundaram, Murali; Felix, A. John William

doi:10.1100/tsw.2004.207

Cited by 15 publications

(12 citation statements)

References 49 publications

(65 reference statements)

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“…Balasubramanian et al have already reported the formation of free radicals in the gastric mucosa of ibuprofen-induced rats. 28 Pre-treatment of glucosamine significantly maintained the activities of membrane bound ATPases by the counteraction of ibuprofen-induced free radicals by the free radical scavenging property of glucosamine. 29 Histopathological investigations showed that ibuprofen administration was characterized by cell damage (Fig.…”

Section: Discussionmentioning

confidence: 96%

Protective effect of glucosamine against ibuprofen‐induced peptic ulcer in rats

Santhosh

Anandan

Sini

et al. 2007

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 96%

Protective effect of glucosamine against ibuprofen‐induced peptic ulcer in rats

Santhosh

Anandan

Sini

et al. 2007

J of Gastro and Hepatol

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“…By blocking ion channels (mainly calcium) within a cell, lead causes autonomic system dysfunction resulting in increased hydrochloric acid secretion and mucosal erosion [25][26][27]. There are reports indicating that the primary pathogenetic factors in ulcers are free radicals [28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

The Content of Elements in Rainwater and Its Relation to the Frequency of Hospitalization for Gastric and Duodenal Peptic Ulcers in Opole Voivodship, Poland, During 2000–2002

Tubek

Bunio

Szyguła

et al. 2010

Biol Trace Elem Res

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The relationship between chemical elements in rainwater and the frequency of hospitalizations for gastric and duodenal peptic ulcers was studied on the population of the province (Voivodship) of Opole, Poland, during the years 2000-2002. There is a high positive correlation between hospitalized cases of gastric peptic ulcers with chromium in rainwater (r = 0.71), cadmium (r = 0.63), and lead (r = 0.70). Mild positive correlations were found with zinc (r = 0.55), copper (r = 0.56), iron (r = 0.57), chloride (r = 0.60), and sulfate (r = 0.52). These correlations were higher on men, suggesting that there are gender correlations involved. In duodenal peptic ulcers, we observed a high positive correlation between chromium in rainwater and hospitalized cases (r = 0.61) and mild positive correlations with lead (r = 0.57), copper (r = 0.52), and cadmium (r = 0.51). Significant gender differences were not found. These positive correlations may be due to the biological activity of the elements, such as their cytotoxic activity, enhanced local adrenergic stimulation on mucosal vasculature, ion channel (mainly calcium channels) remodeling, and, for example promoting infection by Helicobacter pylori.

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“…Such antidote effects of taurine or high capacity for taurine uptake into the cells (or conversely harmful effects of taurine depletion) have i.a . been found against alcohol (23–40), against the analgesic and fever-depressing drug acetaminophen (also called paracetamol) (41–44), against the aminoglycoside antibacterial drug gentamicin (45–47), against the immunosuppressant drug cyclosporine A (48, 49), against the anticancer drugs cisplatin (50–54), doxorubicin (also called adriamycin) (55–62), bleomycin (63–78), methotrexate (79) and taumustine (80), against the cytokine interleukin-2 (IL-2), which is used for immunotherapy of cancer (81–84), against the estrogen receptor modulator tamoxifen, which is used in therapy of breast cancer (85–87), against the antiarrhythmic drug amiodarone (88), against the beta -adrenergic agonists isoproterenol (55) and isoprenaline (89–92), against nicotine (93–95), against oxidized low-density lipoprotein (LDL) (96), against oxidized fish oil (97), against high glucose levels (96, 98–110), against fructose (111–122), against galactose (123), against advanced glycation end-products (AGEs) (100, 124, 125), against homocysteine (126–130), against the anti-inflammatory drugs ibuprofen (131) and indomethacin (132, 133), against the herbicide paraquat (65, 134, 135), against carbon tetrachloride (136–149), against menadione (150), against 1,4-naphtoquinone (137, 139), against hydrazine (137, 139), against trinitrobenzene sulfonic acid (151, 152), against acrylonitrile (153), against perchloroethylene (154), against methylene dianiline (155), against arsenic (156–164), against cadmium (…”

Section: Evidence Showing That Taurine Functions As a Biological Antimentioning

confidence: 99%

Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure.

Christophersen¹

2012

Microbial Ecology in Health & Disease

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There are several animal experiments showing that high doses of ionizing radiation lead to strongly enhanced leakage of taurine from damaged cells into the extracellular fluid, followed by enhanced urinary excretion. This radiation-induced taurine depletion can itself have various harmful effects (as will also be the case when taurine depletion is due to other causes, such as alcohol abuse or cancer therapy with cytotoxic drugs), but taurine supplementation has been shown to have radioprotective effects apparently going beyond what might be expected just as a consequence of correcting the harmful consequences of taurine deficiency per se. The mechanisms accounting for the radioprotective effects of taurine are, however, very incompletely understood. In this article an attempt is made to survey various mechanisms that potentially might be involved as parts of the explanation for the overall beneficial effect of high levels of taurine that has been found in experiments with animals or isolated cells exposed to high doses of ionizing radiation. It is proposed that taurine may have radioprotective effects by a combination of several mechanisms: (1) during the exposure to ionizing radiation by functioning as an antioxidant, but perhaps more because it counteracts the prooxidant catalytic effect of iron rather than functioning as an important scavenger of harmful molecules itself, (2) after the ionizing radiation exposure by helping to reduce the intensity of the post-traumatic inflammatory response, and thus reducing the extent of tissue damage that develops because of severe inflammation rather than as a direct effect of the ionizing radiation per se, (3) by functioning as a growth factor helping to enhance the growth rate of leukocytes and leukocyte progenitor cells and perhaps also of other rapidly proliferating cell types, such as enterocyte progenitor cells, which may be important for immunological recovery and perhaps also for rapid repair of various damaged tissues, especially in the intestines, and (4) by functioning as an antifibrogenic agent. A detailed discussion is given of possible mechanisms involved both in the antioxidant effects of taurine, in its anti-inflammatory effects and in its role as a growth factor for leukocytes and nerve cells, which might be closely related to its role as an osmolyte important for cellular volume regulation because of the close connection between cell volume regulation and the regulation of protein synthesis as well as cellular protein degradation. While taurine supplementation alone would be expected to exert a therapeutic effect far better than negligible in patients that have been exposed to high doses of ionizing radiation, it may on theoretical grounds be expected that much better results may be obtained by using taurine as part of a multifactorial treatment strategy, where it may interact synergistically with several other nutrients, hormones or other drugs for optimizing antioxidant protection and minimizing harmful posttraumatic inflammatory reactions, while using ...

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Taurine Prevents Ibuprofen-Induced Gastric Mucosal Lesions and Influences Endogenous Antioxidant Status of Stomach in Rats

Cited by 15 publications

References 49 publications

Protective effect of glucosamine against ibuprofen‐induced peptic ulcer in rats

Protective effect of glucosamine against ibuprofen‐induced peptic ulcer in rats

The Content of Elements in Rainwater and Its Relation to the Frequency of Hospitalization for Gastric and Duodenal Peptic Ulcers in Opole Voivodship, Poland, During 2000–2002

Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure.

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