Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells

Yanagita, Teruyoshi; Han, Sang Hoon; Hu, Ying; Nagao, Koji; Kitajima, Hideaki; Murakami, Shigeru

doi:10.1186/1476-511x-7-38

Cited by 57 publications

(44 citation statements)

References 22 publications

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“…More recently the effects of taurine on cholesterol and lipid levels have been reported[49]. Zhang et al (2003) showed a hypocholesterolemic effect of dietary taurine in overweight adults[50] and in a 2008 study, taurine was shown to reduce the secretion of apolipoprotein B100 and lipids in liver cells[51]. Hence, taurine supplementation may be beneficial for the prevention of artherosclorosis.…”

Section: Functions Of Vanin In Diseasementioning

confidence: 99%

Diverse biological activities of the vascular non-inflammatory molecules – The Vanin pantetheinases

Kaskow

Proffit

Blangero

et al. 2012

Biochemical and Biophysical Research Communications

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The Vanin genes are a family that encode pantetheinases involved in recycling Coenzyme A, caytalysing the breakdown of intermediate panetheine to vitamin B5 for reuse in CoA biosynthesis. The role of pantetheinase in this most fundamental of cellular processes, was substantially characterised by the 1970s. The next 20 years saw little further interest in pantetheinase until various genetic studies implicated the vanin locus in a range of normal and disease phenotypes, and a consequent interest in the other product of pantetheinase activity, cysteamine. This report seeks to bring together the early biochemical studies with recent biological data implicating cysteamine as a regulator of the oxidative state of a cell. Numerous studies now report a role for Vanin in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease.

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Section: Functions Of Vanin In Diseasementioning

confidence: 99%

Diverse biological activities of the vascular non-inflammatory molecules – The Vanin pantetheinases

Kaskow

Proffit

Blangero

et al. 2012

Biochemical and Biophysical Research Communications

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“…Yanagita T et al noted that the cellular cholesterol levels decreased and synthesis of cholesterol ester was inhibited when the HepG2 cells were incubated in DMEM medium with taurine for 24 h [22]. Lam NV et al reported that taurine significantly increased CYP7A1 mRNA level and promoted cholesterol degradation regardless of whether the HepG2 cells were cultured under the conditions of high cholesterol or not [7], and Hoang HM et al indicated that CYP7A1 mRNA levels increased 3 times when the H4IIE cells were treated with taurine [23].…”

Section: Discussionmentioning

confidence: 99%

Cholesterol-lowing effect of taurine in HepG2 cell

et al. 2017

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BackgroundA number of studies indicate that taurine promotes cholesterol conversion to bile acids by upregulating CYP7A1 gene expression. Few in vitro studies are concerned the concentration change of cholesterol and its product of bile acids, and the molecular mechanism of CYP7A1 induction by taurine.MethodsThe levels of intracellular total cholesterol (TC), free cholesterol (FC), cholesterol ester (EC), total bile acids (TBA) and medium TBA were determined after HepG2 cells were cultured for 24/48 h in DMEM supplemented with taurine at the final concentrations of 1/10/20 mM respectively. The protein expressions of CYP7A1, MEK1/2, c-Jun, p-c-Jun and HNF-4α were detected.ResultsTaurine significantly reduced cellular TC and FC in dose —and time-dependent ways, and obviously increased intracellular/medium TBA and CYP7A1 expressions. There was no change in c-Jun expression, but the protein expressions of MEK1/2 and p-c-Jun were increased at 24 h and inhibited at 48 h by 20 mM taurine while HNF4α was induced after both of the 24 h and 48 h treatment.ConclusionTaurine could enhance CYP7A1 expression by inducing HNF4α and inhibiting MEK1/2 and p-c-Jun expressions to promote intracellular cholesterol metabolism.

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“…In a study conducted by Yanagita and colleagues taurine is found to reduce the secretion of apolipoprotein B100 and lipids in HepG2 cells [43]. Higher concentrations of serum lipids and apolipoprotein B100 (apoB -essential structural component of VLDL and LDL) are major individual risk factors of atherosclerosis and coronary heart disease.…”

Section: Taurinementioning

confidence: 99%

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

Yotova¹

2015

IJNFS

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Email address: M_jotova@mu-pleven Abstract: Caffeine, Taurine and Arginine are one of the most widely used supplements from people of all ages. There are lot of controversial information about their proper use and effects and side effects. Our goal is to determine the reasonable boundaries of using these supplements in healthy people and more important in people with socially important diseases like high blood pressure, diabetes and dementia.

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Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells

Cited by 57 publications

References 22 publications

Diverse biological activities of the vascular non-inflammatory molecules – The Vanin pantetheinases

Diverse biological activities of the vascular non-inflammatory molecules – The Vanin pantetheinases

Cholesterol-lowing effect of taurine in HepG2 cell

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

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