Taurine supplementation ameliorates glucose homeostasis, prevents insulin and glucagon hypersecretion, and controls β, α, and δ-cell masses in genetic obese mice

Santos-Silva, Junia Carolina; Ribeiro, Rosane Aparecida; Vettorazzi, Jean Franciesco; Irles, Esperanza; Rickli, Sarah; Borck, Patrícia Cristine; Porciúncula, Patrı́cia Marafon; Quesada, Iván; Nadal, Ángel; Boschero, Antônio Carlos; Carneiro, Everardo M.

doi:10.1007/s00726-015-1988-z

Cited by 50 publications

(22 citation statements)

References 58 publications

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“…Surprisingly, taurine treatment abolished the daily pattern of glucose-stimulated insulin secretion in isolated islets from HFD-fed mice. The reason is not known, but it could be possible that taurine could modulate important metabolic genes involved in the regulation of insulin secretion and beta-cell mass, as shown in previous studies with taurine supplementation in obese animals4142.…”

Section: Discussionmentioning

confidence: 99%

Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet

Figueroa

Alves-Figueiredo

Rebuffat

et al. 2016

Sci Rep

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Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T). They were administered 2% taurine in their drinking water for 10 weeks. Mice were euthanized at 6:00, 12:00, 18:00, and 24:00. HFD mice increased body weight, visceral fat and food intake, as well as higher levels of glucose, insulin and leptin, throughout the 24 h. Taurine prevented increments in food intake, body weight and visceral fat, improved glucose tolerance and insulin sensitivity and reduced disturbances in the 24 h patterns of plasma insulin and leptin. HFD downregulated the expression of clock genes Rev-erbα, Bmal1, and Per1 in pancreatic islets. Taurine normalized the gene and protein expression of PER1 in beta-cells, which suggests that it could be beneficial for the correction of daily rhythms and the amelioration of obesity and diabetes.

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Section: Discussionmentioning

confidence: 99%

Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet

Figueroa

Alves-Figueiredo

Rebuffat

et al. 2016

Sci Rep

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“…During each enteral-hepatic cycle, about 95% of the liver-derived bile salts are reabsorbed to the liver. ASBT apical sodium-dependent bile salt/acid transporter (in ileal enterocytes), BA bile acids (unconjugated), BSEP bile salt export pump, CBA conjugated bile acids, Gly glycine, GlyT glycine transporters, M3 multidrug resistance protein-3, MBSL microbial bile salt hydrolases, NTCP Na + -taurocholate cotransporting polypeptide, OATP organic anion transporting polypeptide family, OSTα/β organic solute transporter subunit α/β, PD passive diffusion, Tau taurine, TauT taurine transporters taurine can ameliorate structural abnormalities of the pancreas (Santos-Silva et al 2015), while improving insulin production by pancreatic β-cells (Nakatsuru et al 2018) and whole-body insulin sensitivity in subjects with hyperglycemia (Sarkar et al 2017). This role of taurine in diabetic patients are highly significant, because they have a 25% lower concentration of taurine in plasma than normal subjects (Sak et al 2019) and that the number of type-2 diabetic patients is increasing globally (Willet et al 2019).…”

Section: Health Benefits Of Taurine Supplementationmentioning

confidence: 99%

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

2020

Amino Acids

352

192

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Taurine (a sulfur-containing β-amino acid), creatine (a metabolite of arginine, glycine and methionine), carnosine (a dipeptide; β-alanyl-l-histidine), and 4-hydroxyproline (an imino acid; also often referred to as an amino acid) were discovered in cattle, and the discovery of anserine (a methylated product of carnosine; β-alanyl-1-methyl-l-histidine) also originated with cattle. These five nutrients are highly abundant in beef, and have important physiological roles in anti-oxidative and antiinflammatory reactions, as well as neurological, muscular, retinal, immunological and cardiovascular function. Of particular note, taurine, carnosine, anserine, and creatine are absent from plants, and hydroxyproline is negligible in many plant-source foods. Consumption of 30 g dry beef can fully meet daily physiological needs of the healthy 70-kg adult human for taurine and carnosine, and can also provide large amounts of creatine, anserine and 4-hydroxyproline to improve human nutrition and health, including metabolic, retinal, immunological, muscular, cartilage, neurological, and cardiovascular health. The present review provides the public with the much-needed knowledge of nutritionally and physiologically significant amino acids, dipeptides and creatine in animal-source foods (including beef). Dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline are beneficial for preventing and treating obesity, cardiovascular dysfunction, and ageing-related disorders, as well as inhibiting tumorigenesis, improving skin and bone health, ameliorating neurological abnormalities, and promoting well being in infants, children and adults. Furthermore, these nutrients may promote the immunological defense of humans against infections by bacteria, fungi, parasites, and viruses (including coronavirus) through enhancing the metabolism and functions of monocytes, macrophages, and other cells of the immune system. Red meat (including beef) is a functional food for optimizing human growth, development and health.

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“…Also, it can induce apoptosis and inhibit the proliferation of HCC HepG2 cells [26] and induced apoptosis of human colon cancer [27]. Tau also could prevent the development of ameliorates glycemia, the action of insulin, and dyslipidemia in type 2 diabetes mellitus (T2DM) [28]. Another study showed that post-treatment supplemention of taurine is recommended for T2DM [29].…”

Section: Introductionmentioning

confidence: 99%

Comparison between Fibroscan and Serum Taurine for Early Diagnosis of Liver Fibrosis in Egyptian Patients Infected with HCV

Agouza¹,

Fouad²,

Ahmed³

et al. 2017

Clin Med Biochemistry

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Aim: The aim is to evaluate the role of measuring serum taurine level as an early biomarker for detection and staging of hepatic fibrosis in comparison to Fibroscan. Patients and methods:70 patients who are positive HCV are classified into five groups according to the scoring of Fibroscan. 10 healthy subjects were also enrolled as control group. Full clinical examination and complete biochemical analysis in addition to fibroscan and serum taurine as new marker are performed for all the selected patients and volunteers. Results:Results showed non-significant changes in the most Analytical data between the five groups of patients and control group, but a significant Increment in the serum level of ALT and AST in F4 Stage is noticed and marked decrease in platelets also found in F4. The most interesting point recorded is that Serum taurine levels were exhibited a value markedly lower than that recorded in control group and its decline was related to the severity of the diseases. Conclusion:It is suggested that the assessment of taurine level in sera of all hepatic patients beside fibroscan are of great value in the early diagnosis of any fibrotic changes in liver.

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Taurine supplementation ameliorates glucose homeostasis, prevents insulin and glucagon hypersecretion, and controls β, α, and δ-cell masses in genetic obese mice

Cited by 50 publications

References 58 publications

Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet

Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

Comparison between Fibroscan and Serum Taurine for Early Diagnosis of Liver Fibrosis in Egyptian Patients Infected with HCV

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