Taurine supplementation enhances nutrient‐induced insulin secretion in pancreatic mice islets

Abstract

TAU supplementation improves glucose tolerance and insulin sensitivity in mice, as well as insulin secretion from isolated islets. The latter effect seems to be, at least in part, dependent on a better Ca(2+) handling by the islets.

Post-exercise taurine administration enhances glycogen repletion in tibialis anterior muscle

“…2B). This effect of taurine treatment is in agreement with some rodent studies that showed taurine administration attenuated the increase of blood glucose concentration during glucose tolerance testing [11][12][13][14][15][16][17] . In general, most glucose (>80%) is taken up by skeletal muscle 21) .…”

“…Glycogen repletion in skeletal muscle after exercise is one of the major determinants of performance during subsequent exercise since higher pre-exercise glycogen content in skeletal muscle resulted in improving performance during both prolonged endurance and high-intensity intermittent exercise [2][3][4][5] . Some rodent studies have shown the possibility that taurine administration enhances glucose uptake in tissues [11][12][13][14][15][16][17] , which is one of the limiting factors for glycogen synthesis in skeletal muscle. Therefore, we hypothesized that taurine administration enhanced postexercise glycogen repletion in skeletal muscle.…”

“…Although we should consider that there are possibilities that taurine admin- treatment is stimulation of insulin secretion. Some studies demonstrated that taurine administration improved glucose tolerance in rodents without altering the plasma insulin concentration 11,13) ; whereas others reported that taurine administration increased insulin secretion from islets 14,16,17) . In our experiment, no significant difference was observed in the plasma insulin concentration between the two groups ( Fig.…”

“…These results suggest that taurine administration has some positive effects during the post-exercise phase. Some rodent studies have demonstrated the possibility that taurine administration enhances glucose uptake, one of the rate-limiting factors for glycogen resynthesis in skeletal muscle [11][12][13][14][15][16][17] . Moreover, Kulakowski et al showed that a single dose of taurine was able to increase glycogen content in the liver at resting state in non-diabetic rats 11) .…”

Developmental programming of the metabolic syndrome - critical windows for intervention

“…Studies have shown that taurine concentrations are low in diabetic and pre-diabetic states and that physiological plasma taurine levels are important for adequate β-cell function and insulin action [135] . In MLP rat offspring, β-cell mass is decreased at birth and metabolic perturbations last through adulthood even though a normal diet is given after birth or after weaning [136] .…”