Taurine supplementation modulates glucose homeostasis and islet function

Carneiro, Everardo M.; Latorraca, Márcia Queiroz; Araujo, Eliana P.; Beltrá, Marta; Oliveras, Maria J.; Navarro, Mónica; Berná, Genoveva; Bedoya, Francisco J.; Velloso, Lı́cio A.; Soria, Bernat; Martı́n, Franz

doi:10.1016/j.jnutbio.2008.05.008

Cited by 122 publications

(76 citation statements)

References 35 publications

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“…2B). This effect of taurine treatment is in agreement with some rodent studies that showed taurine administration attenuated the increase of blood glucose concentration during glucose tolerance testing [11][12][13][14][15][16][17] . In general, most glucose (>80%) is taken up by skeletal muscle 21) .…”

Section: Discussionsupporting

confidence: 90%

“…Glycogen repletion in skeletal muscle after exercise is one of the major determinants of performance during subsequent exercise since higher pre-exercise glycogen content in skeletal muscle resulted in improving performance during both prolonged endurance and high-intensity intermittent exercise [2][3][4][5] . Some rodent studies have shown the possibility that taurine administration enhances glucose uptake in tissues [11][12][13][14][15][16][17] , which is one of the limiting factors for glycogen synthesis in skeletal muscle. Therefore, we hypothesized that taurine administration enhanced postexercise glycogen repletion in skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

“…Although we should consider that there are possibilities that taurine admin- treatment is stimulation of insulin secretion. Some studies demonstrated that taurine administration improved glucose tolerance in rodents without altering the plasma insulin concentration 11,13) ; whereas others reported that taurine administration increased insulin secretion from islets 14,16,17) . In our experiment, no significant difference was observed in the plasma insulin concentration between the two groups ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…These results suggest that taurine administration has some positive effects during the post-exercise phase. Some rodent studies have demonstrated the possibility that taurine administration enhances glucose uptake, one of the rate-limiting factors for glycogen resynthesis in skeletal muscle [11][12][13][14][15][16][17] . Moreover, Kulakowski et al showed that a single dose of taurine was able to increase glycogen content in the liver at resting state in non-diabetic rats 11) .…”

Section: Introductionmentioning

confidence: 99%

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Post-exercise taurine administration enhances glycogen repletion in tibialis anterior muscle

Takahashi

Matsunaga

Tamura

et al. 2014

JPFSM

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Previous studies suggested that taurine (2-aminoethanesulfonic acid) administration enhances glucose uptake, one of the rate-limiting factors for glycogen synthesis. In this study, we investigated the effects of post-exercise taurine administration on glycogen repletion in skeletal muscle in ICR mice. In experiment 1, we orally administered either taurine (0.5 mg/ g body weight) solution or physiological saline immediately after treadmill running at 25 m/ min for 90 min. The serum free fatty acid (FFA) concentration at 60 min after the exercise was significantly higher in the taurine-treated group compared with the control group (p < 0.05). At 120 min after the exercise, the tibialis anterior muscle glycogen concentration in the taurinetreated group was significantly higher than that in the control group (p < 0.05). In experiment 2, we orally administered either glucose (1 mg/g body weight) solution or glucose solution containing taurine immediately after and at 60 min after the exercise. The area under the curve (AUC) for blood glucose concentration from 0 to 60 min after the exercise was significantly smaller in the taurine-treated group compared with the control group (p < 0.01). Our results show that post-exercise taurine administration enhances glycogen repletion in skeletal muscle. Higher skeletal muscle glycogen concentration by taurine administration may be partly due to the acceleration of glucose uptake. In addition, as the elevation of blood FFA level leads to an increase in fat oxidation, it is possible that a higher serum FFA concentration by taurine treatment is related to the sparing of carbohydrate for glycogen repletion.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Post-exercise taurine administration enhances glycogen repletion in tibialis anterior muscle

Takahashi

Matsunaga

Tamura

et al. 2014

JPFSM

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“…Animal models of protein malnutrition have provided important insights into the adaptive mechanisms involved in insulin secretion in malnutrition (88) . Mice supplemented with taurine (2 %) have higher insulin content, and insulin secretion from isolated islets accompanied by higher expression of genes required for glucose-stimulated insulin secretion including GK (89,90) . Regulation of glucokinase by dietary fat: liver.…”

Section: Rattus Norvegicusmentioning

confidence: 99%

Nutritional regulation of glucokinase: a cross-species story

Panserat

Rideau²,

Polakof

2014

Nutr. Res. Rev.

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The glucokinase (GK) enzyme (EC 2.7.1.1.) is essential for the use of dietary glucose because it is the first enzyme to phosphorylate glucose in excess in different key tissues such as the pancreas and liver. The objective of the present review is not to fully describe the biochemical characteristics and the genetics of this enzyme but to detail its nutritional regulation in different vertebrates from fish to human. Indeed, the present review will describe the existence of the GK enzyme in different animal species that have naturally different levels of carbohydrate in their diets. Thus, some studies have been performed to analyse the nutritional regulation of the GK enzyme in humans and rodents (having high levels of dietary carbohydrates in their diets), in the chicken (moderate level of carbohydrates in its diet) and rainbow trout (no carbohydrate intake in its diet). All these data illustrate the nutritional importance of the GK enzyme irrespective of feeding habits, even in animals known to poorly use dietary carbohydrates (carnivorous species).

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Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation

Sarnobat

Moffett

et al. 2023

BioFactors

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The semi-essential ubiquitous amino acid taurine has been shown to alleviate obesity and hyperglycemia in humans; however, the pathways underlying the antidiabetic actions have not been characterized. We explored the effect of chronic taurine exposure on cell biology of pancreatic islets, in degenerative type 1-like diabetes. The latter was modeled by small dose of streptozotocin (STZ) injection for 5 days in mice, followed by a 10-day administration of taurine (2% w/v, orally) in the drinking water. Taurine treatment opposed the detrimental changes in islet morphology and β-/α-cell ratio, induced by STZ diabetes, coincidentally with a significant 3.9 ± 0.7-fold enhancement of proliferation and 40 ± 5% reduction of apoptosis in β-cells. In line with these findings, the treatment counteracted an upregulation of antioxidant (Sod1, Sod2, Cat, Gpx1) and downregulation of islet expansion (Ngn3, Itgb1) genes induced by STZ, in a pancreatic β-cell line. At the same time, taurine enhanced the transdifferentiation of α-cells into β-cells by 2.3 ± 0.8-fold, echoed in strong non-metabolic elevation of cytosolic Ca 2+ levels in pancreatic α-cells. Our data suggest a bimodal effect of dietary taurine on islet β-cell biology, which combines the augmentation of α-/β-cell transdifferentiation with downregulation of apoptosis. The dualism of action, stemming presumably from the intra-and extracellular modality of the signal, is likely to explain the antidiabetic potential of taurine supplementation.

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Taurine supplementation modulates glucose homeostasis and islet function

Cited by 122 publications

References 35 publications

Post-exercise taurine administration enhances glycogen repletion in tibialis anterior muscle

Post-exercise taurine administration enhances glycogen repletion in tibialis anterior muscle

Nutritional regulation of glucokinase: a cross-species story

Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation

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