Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats: involvement of Ach-M3R, Synt 1 and SNAP-25 proteins

Batista, Thiago M.; Ribeiro, Rosane Aparecida; Amaral, Andressa Godoy; Oliveira, Camila Aparecida Machado de; Boschero, Antônio Carlos; Carneiro, Everardo M.

doi:10.1016/j.jnutbio.2010.12.012

Cited by 48 publications

(54 citation statements)

References 47 publications

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“…In the hypothalamus, Tau decreases NPY expression and enhances the anorexigenic effects of insulin (Solon et al 2012). In the periphery, Tau also improves insulin secretion (Ribeiro et al 2009;Batista et al 2012), increases insulin receptor phosphorylation (Camargo et al 2013), and prevents obesity (Tsuboyama-Kasaoka et al 2006;Batista et al 2013b). Here, using a microarray analysis, we found that several genes involved in the hypothalamic control of food intake are altered in protein-restricted mice.…”

Section: Introductionmentioning

confidence: 61%

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

et al. 2015

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Malnutrition programs the neuroendocrine axis by disruption of food-intake control, leading to obesity. Taurine (Tau) is neuroprotective and improves anorexigenic actions in the hypothalamus. We evaluated the hypothalamic gene-expression profile and food-intake control in protein-restricted mice submitted to a high-fat diet (HFD) and Tau supplementation. Mice were fed on a control (14 % protein-C) or a protein-restricted diet (6 % protein-R) for 6 weeks. Thereafter, mice received, or not, HFD for 8 weeks (CH and RH) with or without 5 % Tau supplementation (CHT and RHT). Protein restriction led to higher food intake, but calories were matched to controls. Excessive calorie intake occurred in HFD mice and this was prevented by Tau supplementation only in the CH group. Additionally, RH and CH mice developed hypothalamic leptin resistance, which was prevented by Tau. Global alterations in the expressions of genes involved in hypothalamic metabolism, cellular defense, apoptosis and endoplasmic reticulum stress pathways were induced by dietary manipulations and Tau treatment. The orexigenic peptides NPY and AgRP were increased by protein restriction and lowered by the HFD. The anorexigenic peptide Pomc was increased by HFD, and this was prevented by Tau only in CH mice. Thus, food intake was disrupted by dietary protein restriction and obesity. HFD-induced alterations were not enhanced by previous protein deficiency, but the some beneficial effects of Tau supplementation upon food intake were blunted by protein restriction. Tau effects upon feeding behavior control are complex and involve interactions with a vast gene network, preventing hypothalamic leptin resistance.

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Section: Introductionmentioning

confidence: 61%

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

et al. 2015

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“…20,27 Acetylcholine, for example, when released from cholinergic terminals, binds to muscarinic receptors in pancreatic islets, potentiating nutrient-induced insulin secretion by activating phospholipase C, generating diacylglycerol (DAG) and inositol-1,4,5 triphosphate (IP3). DAG activates PKC, increasing the efficiency of cytosolic Ca 2+ on exocytosis of insulin granules; while IP3 releases Ca 2+ from endoplasmic reticulum.…”

Section: Resultsmentioning

confidence: 99%

“…DAG activates PKC, increasing the efficiency of cytosolic Ca 2+ on exocytosis of insulin granules; while IP3 releases Ca 2+ from endoplasmic reticulum. 27,28 We observed that trained animals, submitted to an acute exercise session, increase their insulin secretion stimulated by the cholinergic agent carbachol. Our group was the first to observe this fact.…”

Section: Resultsmentioning

confidence: 99%

Physical exercise and pancreatic islets

Almeida

Proença

Chimin

et al. 2012

Islets

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“…However, to induce protein malnutrition, after weaning, animals received low-protein diet containing 6% protein. The intake of this diet remained until the end of the experimental period (day 105) 11 . Body weight of animals and weight of retroperitoneal and perigonadal adipose tissues were used as variables for evaluation and characterization of obese and malnourished groups.…”

Section: Obesity and Protein Malnutrition Inductionmentioning

confidence: 99%

Imobilização articular: efeitos sobre o tecido muscular de camundongos obesos e desnutridos

Rissi

Lemos

Ide

et al. 2016

Rev. Bras. Cineantropom. Desempenho Hum.

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-Although it is a widely used resource for the treatment of musculoskeletal injuries, immobilization causes deleterious effects in muscle tissue after a short period of time. This study aimed to evaluate the gastrocnemius and tibialis anterior muscles of obese and protein malnourished animals under joint immobilization condition. Overall, 28 adult male mice were used (C57 / BL6), being divided into four groups (N = 7): Control Group (CG), Immobilized Control Group (ICG), Immobilized Obese Group (IOG) and Immobilized Malnourished Group (IMG). The immobilization protocol was performed by the use of adhesive tape and plaster. The conditions and obesity and protein malnutrition have been developed through the ingestion of diets specific for each group of animals. The histomorphometric analysis of muscles evaluated area and the diameter of muscle fibers. All immobilized groups showed reduction in the area and diameter of muscle fibers when compared to GC. Comparisons among immobilized groups showed that the area and diameter of muscle fibers of IOG and IMG were lower than ICG. The immobilization protocol caused reduction in muscle trophism in animals, and obese and malnourished animals suffered high losses under condition of muscle atrophy.Key words: Immobilization; Muscular atrophy; Protein malnutrition; Obesity. Resumo -Embora seja um recurso muito utilizado para tratamento de lesões musculoesqueléticas, a imobilização causa efeitos deletérios no tecido muscular após curto período de tempo. O presente estudo teve como objetivo avaliar os músculos gastrocnêmio e tibial anterior de animais obesos e desnutridos proteicamente sob a condição de imobilização articular. Foram utilizados 28 camundongos (C57/BL6) machos adultos, distribuídos em quatro grupos (N=7): Grupo controle (GC), Grupo Controle Imobilizado (GCI), Grupo Obeso imobilizado (GOI) e Grupo Desnutrido Imobilizado (GDI

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Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats: involvement of Ach-M3R, Synt 1 and SNAP-25 proteins

Cited by 48 publications

References 47 publications

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

Physical exercise and pancreatic islets

Imobilização articular: efeitos sobre o tecido muscular de camundongos obesos e desnutridos

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