Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits

Murakami, Shigeru; Kondo, Yukiko; Sakurai, Takanobu; Kitajima, Hideaki; Nagate, Takatoshi

doi:10.1016/s0021-9150(01)00764-x

Cited by 69 publications

(35 citation statements)

References 46 publications

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“…Inverse correlation between intake of antioxidants and cardiovascular diseases were shown in epidemiological studies (1)(2)(3). In FH model animals such as WHHL rabbits and KHC rabbits, natural antioxidative substances like vitamin E (30) and taurine (31), herbal medicines containing flavonoid (32,33), and hypocholesterolemic agent possessing antioxidative activity, probucol (34,35) were reported to suppress development of atherosclerosis. These antioxidative substances exert anti-atherosclerotic effect without decreasing plasma cholesterol.…”

Section: Discussionmentioning

confidence: 96%

Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits

Kurosawa

Itoh

Nozaki

et al. 2005

J Atheroscler Thromb

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We investigated the suppressive effect of cocoa powder (cacao polyphenol content: 7.8%) on atherosclerosis in a spontaneous familial hypercholesterolemic model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Six-month dietary administration of cocoa powder had no effects on body weight, hematology or blood chemistry parameters or a lipid profile in KHC rabbits. Antioxidative activity of lowdensity lipoprotein (LDL) was observed in the 2nd month and 3rd month of administration. Thiobarbituric acid reactive substances (TBARS), the marker of lipid peroxidation, in plasma were decreased in the cocoa powder treated group from the 2nd month of administration during the study period compared to that in the control group. The area of atherosclerotic lesions in th aorta was significantly smaller in the cocoa powder group (30.87%) than in the control (52.39%). Tissue cholesterol content also tended to decrease. Distensibility of the aortic wall was improved significantly in the cocoa powder treated group due to decreases in fatty streaks and intimal thickening compared to that in the control group. These results suggest that cocoa powder has suppressive effect on development of atherosclerotic lesions. We consider that antioxidative activity of polyphenols rich in cocoa powder may be a key factor for the anti-atherosclerotic effect. J Atheroscler Thromb, 2005; 12: 20-28.

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Section: Discussionmentioning

confidence: 96%

Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits

Kurosawa

Itoh

Nozaki

et al. 2005

J Atheroscler Thromb

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“…Several studies have demonstrated that dietary taurine showed a notable cholesterollowering effect in hypercholesterolemic rats fed a high cholesterol diet (Masuda and Horisaki, 1986;Murakami et al, 1999;Park and Lee, 1998;Hagar, 2004). It has been shown that taurine improves endothelial function and inhibits apoptosis of endothelial cell as well as decreases plasma level of LDL, which prevents initiation and progression of atherosclerosis (Fennessy et al, 2003;Murakami et al, 2002). Taurine exhibits antioxidative properties, membrane stabilizing effect, regulates intracellular Ca2+ concentration, inhibits apoptosis, reduces the levels of pro-inflammatory cytokines in various organs and controls blood pressure (Das et al, 2008;Manna et al, 2008;2009).…”

Section: Introductionmentioning

confidence: 99%

Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

Abdel-Rahman¹

2014

OnLine Journal of Biological Sciences

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A hypercholesterolemia diet has been associated with the hepatic and cardiac abnormalities and the pathological changes. The present work was designed to investigate the histological and immunohistochemical changes in the liver and heart of rabbits when fed high fat diet and the possible protective role of an antioxidant "taurine". Twenty-four male white New Zealand rabbits were divided into four groups, 6 rabbits each. Group 1, served as a control, rabbits fed with a normal diet. Group 2, (taurine group), rabbits were given orally taurine (10 mg Kg −1 b.w/day) for 8 weeks. Group 3 (hypercholesterolemic group), rabbits fed (2% cholesterol-enriched diet for 8 weeks. Group 4, rabbits fed 2% cholesterol-enriched diet plus taurine (10 mg Kg −1 b.w/day) orally for the same period. Histopathological examinations revealed that high cholesterol diet caused hepatic and myocardial tissue changes compared with rabbits fed with a normal diet. Including fatty degeneration, inflammations and necrosis of Hepatocytes and vacuolar degeneration, disorganization of myofibrils and necrosis of myocardial cells. Immunohistochemistry for caspase-3 for apoptosis were performed. Caspase-3 positive cells in the liver tissue and Caspase-3 positive area in myocardial tissue increased in high cholesterol diet group. Taurine markedly attenuate hypercholesterolemia-induced cardiac and hepatic histopathological changes in the cholesterol plus taurine group compared to the cholesterol group. Thus, the results suggest that taurine could play a beneficial role against hypercholesterolemiainduced complications in the liver and heart of the rabbits.

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“…LC and TAU can exert therapeutic effects on atherosclerosis [14,[16][17][18][22][23][24][25] . Our present data indicate that LC and TAU synergistically inhibit the proliferation and β-GP-induced osteoblastic differentiation of VSMCs.…”

Section: Discussionmentioning

confidence: 99%

“…The molecular mechanism underlying this protective effect is obscure; some researchers have attributed this effect to its cholesterol-lowering properties [36] . However, others reported that TAU could prevent atherosclerosis without significantly affecting the serum cholesterol level [14] . Currently, TAU and its analogues are reported to suppress the proliferation of VSMCs [16] .…”

Section: Discussionmentioning

confidence: 99%

“…This result suggested that TAU intake could be effective in preventing cardiovascular disease [13] . Murakami et al [14] showed that TAU prevented the progression of atherosclerosis in rabbits, indicating its potential therapeutic role in atherosclerosis. Moreover, our previous study demonstrated that TAU transporter (TAUT) was expressed in VSMCs [15] .…”

Section: Introductionmentioning

confidence: 99%

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L-carnitine and taurine synergistically inhibit the proliferation and osteoblastic differentiation of vascular smooth muscle cells

et al. 2010

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Aim: To investigate the synergistic action of L-carnitine (LC) and taurine (TAU) on the proliferation and osteoblastic differentiation of vascular smooth muscle cells (VSMCs). Methods: DNA and protein synthesis of VSMCs were assessed using scintillation counting. Alkaline phosphatase (ALP) activity and calcium content were determined to investigate the effects of LC and TAU on the osteoblastic differentiation and mineralization of VSMCs. TAU uptake by VSMCs was assayed. RNA interference was used to down-regulate the expression of the TAU transporter (TAUT) in rat VSMCs. Results: LC and TAU synergistically inhibited the proliferation and β-glycerophosphate (β-GP)-induced osteoblastic differentiation of VSMCs as evidenced by the decreased [ 3 H]thymidine incorporation, ALP activity and calcium deposition. Furthermore, LC stimulated the TAU uptake and TAUT expression in VSMCs. Suppression of TAUT with short hairpin RNA (shRNA) abolished the synergistic action of LC and TAU in VSMCs. Conclusion: The synergistic inhibitory action of LC and TAU on the proliferation and osteoblastic differentiation of VSMCs is attributable to the up-regulation of TAUT expression and TAU uptake by LC.

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Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits

Cited by 69 publications

References 46 publications

Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits

Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits

Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

L-carnitine and taurine synergistically inhibit the proliferation and osteoblastic differentiation of vascular smooth muscle cells

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