Taurine treatment decreases inflammation and oxidative stress in lungs of adult mice exposed to cigarette smoke

Ramos, Camila de Oliveira; Campos, Keila Karine Duarte; Costa, Guilherme de Paula; Cangussú, Sílvia Dantas; Talvani, André; Bezerra, Frank Silva

doi:10.1016/j.yrtph.2018.07.008

Cited by 26 publications

(15 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rodents treated with taurine prior to and after bleomycin-induced acute lung injury showed an absence of pulmonary fibrosis and reduced inflammation markers, including iNOS, intracellular adhesion molecule, TNFα, NF-Kβ, and interleukin (IL) 2, when compared with the untreated group [127][128][129][130][131]. Similar anti-inflammatory effects of taurine have been replicated in endotoxin [132,133] and cigarette smoke [134] models of acute lung injury. After spinal cord injuries, treatment with taurine was able to reduce inflammation, decrease accumulation of neutrophils and secondary degenerative consequences in gray matter, attenuate motor disturbances, and promote axonal regeneration [135,136].…”

Section: Taurine Toll-like Receptors and Cardiovascular Diseasementioning

confidence: 72%

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

et al. 2020

View full text Add to dashboard Cite

Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With its unique sulfonic acid makeup, taurine influences cellular functions, including osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids. Taurine exerts anti-inflammatory effects that improve diabetes and has shown benefits to the cardiovascular system, possibly by inhibition of the renin angiotensin system. The beneficial effects of taurine are reviewed.

show abstract

Section: Taurine Toll-like Receptors and Cardiovascular Diseasementioning

confidence: 72%

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The right lung was collected, and 100 mg of tissue was homogenized with 1 mL phosphate buffer (pH 7.8), the samples were centrifuged for 10 min at 4°C and 13000 r/min, and the supernatant was collected and stored at −80°C. 24…”

Section: Methodsmentioning

confidence: 99%

Sigh maneuver protects healthy lungs during mechanical ventilation in adult Wistar rats

Silva

Matos

Souza

et al. 2020

Exp Biol Med (Maywood)

Self Cite

View full text Add to dashboard Cite

Mechanical ventilation (MV) is a tool used for the treatment of patients with acute or chronic respiratory failure. However, MV is a non-physiological resource, and it can cause metabolic disorders such as release of pro-inflammatory cytokines and production of reactive oxygen species. In clinical setting, maneuvers such as sigh, are used to protect the lungs. Thus, this study aimed to evaluate the effects of sigh on oxidative stress and lung inflammation in healthy adult Wistar rats submitted to MV. Male Wistar rats were divided into four groups: control (CG), mechanical ventilation (MVG), MV set at 20 sighs/h (MVG20), and MV set at 40 sighs/h (MVG40). The MVG, MVG20, and MVG40 were submitted to MV for 1 h. After the protocol, all animals were euthanized and the blood, bronchoalveolar lavage fluid, and lungs were collected for subsequent analysis. In the arterial blood, MVG40 presented higher partial pressure of oxygen and lower partial pressure of carbon dioxide compared to control. The levels of bicarbonate in MVG20 were lower compared to CG. The neutrophil influx in bronchoalveolar lavage fluid was higher in the MVG compared to CG and MVG40. In the lung parenchyma, the lipid peroxidation was higher in MVG compared to CG, MVG20, and MVG40. Superoxide dismutase and catalase activity were higher in MVG compared to CG, MVG20, and MVG40. The levels of IL-1, IL-6, and TNF in the lung homogenate were higher in MVG compared to CG, MVG20, and MVG40. The use of sigh plays a protective role as it reduced redox imbalance and pulmonary inflammation caused by MV.

show abstract

“…They were stained with the Quick Panoptic Kit (Laborclin, Pinhais, Paraná, Brazil). A total of 100 leukocytes were counted per slide, which were differentiated into monocytes, neutrophils, and lymphocytes [31].…”

Section: Methodsmentioning

confidence: 99%

Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice

Bezerra

Ramos

Castro

et al. 2019

ICMx

Self Cite

View full text Add to dashboard Cite

Background In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects during hyperoxia. Methods Male BALB/c mice (8–10 weeks), a strain highly sensitive to hyperoxia, received the exogenous surfactant-containing protein SP-B and SP-C by intranasal instillation 12 h before starting 24 h of exposure to hyperoxia in an inhalation chamber and were compared to mice receiving hyperoxia alone and to controls subjected to normoxia. Results Compared to the hyperoxia group, the administration of exogenous surfactant was able to reduce lung inflammation through a reduction in the influx of neutrophils and inflammatory biomarkers such as TNF, IL-17, and HMGB1 expression. The antioxidant activity prevented oxidative damage by reducing lipid peroxidation and protein carbonylation and increasing superoxide dismutase activity when compared to the hyperoxia group. Conclusion Our results offer new perspectives on the effects and the mechanism of exogenous surfactant in protecting the airway and lungs, in oxygen-rich lung microenvironment, against oxidative damage and aggravation of acute inflammation induced by hyperoxia.

show abstract

Taurine treatment decreases inflammation and oxidative stress in lungs of adult mice exposed to cigarette smoke

Cited by 26 publications

References 54 publications

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

Sigh maneuver protects healthy lungs during mechanical ventilation in adult Wistar rats

Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice

Contact Info

Product

Resources

About