Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: The role of hydrogen sulfide

Guizoni, Daniele M.; Freitas, Israelle N.; Victório, Jamaira A.; Possebom, Isabela R.; Araújo, Thiago R.; Carneiro, Everardo M.; Davel, Ana Paula

doi:10.1016/j.metabol.2021.154701

Cited by 18 publications

(16 citation statements)

References 54 publications

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“…With respect to Sirt1, both its activity and its expression can be increased by endogenously generated hydrogen sulfide (H 2 S), which directly sulfhydrates Sirt1 111. This might rationalise several reports that supplemental taurine can boost Sirt1 activity; taurine has been shown to enhance expression of the H 2 S-generating enzymes cystathionine β-synthase and cystathionine γ-lyase in vascular tissues, an effect which might be generalisable to other tissues 112–116. Likewise, administration of N-acetylcysteine, a delivery form of the cysteine that serves as substrate for H 2 S biosynthesis, has been found to increase Sirt1 activity or expression in rodents 117 118…”

Section: Ancillary Nutraceuticals May Amplify the Beneficial Impacts ...mentioning

confidence: 84%

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

et al. 2022

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Ferulic acid, a bacterial metabolite of anthocyanins, seems likely to be a primary mediator of the health benefits associated with anthocyanin-rich diets, and has long been employed in Chinese cardiovascular medicine. In rodent studies, it has exerted wide-ranging antioxidant and anti-inflammatory effects, the molecular basis of which remains rather obscure. However, recent studies indicate that physiologically relevant concentrations of ferulic acid can boost expression of Sirt1 at mRNA and protein levels in a range of tissues. Sirt1, a class III deacetylase, functions to detect a paucity of oxidisable substrate, and in response works in various ways to promote cellular survival and healthful longevity. Sirt1 promotes ‘cell cleansing’ and cell survival by boosting autophagy, mitophagy, mitochondrial biogenesis, phase 2 induction of antioxidant enzymes via Nrf2, and DNA repair—while inhibiting NF-kB-driven inflammation, apoptosis, and cellular senescence, and boosting endothelial expression of the protective transcription factor kruppel-like factor 2. A deficit of the latter appears to mediate the endothelial toxicity of the SARS-CoV-2 spike protein. Ferulic acid also enhances the activation of AMP-activated kinase (AMPK) by increasing expression and activity of its activating kinase LKB1—whereas AMPK in turn amplifies Sirt1 activity by promoting induction of nicotinamide phosphoribosyltranferase, rate-limiting for generation of Sirt1’s obligate substrate NAD+. Curiously, AMPK acts by independent mechanisms to potentiate many of the effects mediated by Sirt1. Hence, it is proposed that ferulic acid may exert complementary or synergistic health-promoting effects when used in conjunction with clinically useful AMPK activators, such as the nutraceutical berberine. Additional nutraceuticals which might have potential for amplifying certain protective effects of ferulic acid/berberine are also discussed.

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Section: Ancillary Nutraceuticals May Amplify the Beneficial Impacts ...mentioning

confidence: 84%

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

et al. 2022

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“…In addition, poor nutrient status, the inflammation, and oxidative stress were closely related, which may have a vital impact on the immune system ( 28 ). Finally, nutritional status was closely related to endothelial dysfunction ( 29 , 30 ) and sympathetic activity ( 31 , 32 ). Numerous previous studies from basic science have confirmed that oxidative stress, inflammatory processes, endothelial dysfunction, and insulin resistance play important roles in developing LVH ( 33 – 36 ).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Famine Exposure During Early Life and Left Ventricular Hypertrophy in Adulthood

et al. 2022

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BackgroundAlthough the evidence was still limited, some studies suggested that childhood malnutrition might affect cardiac function and structure in adulthood. To address the knowledge gap, this study investigated if the Great Chinese Famine exposure during early life had affected left ventricular hypertrophy (LVH).MethodsThis research was a cross-sectional study. It included participants who had cardiac ultrasound assessments and were born in Guangdong, China, from 1 October 1952 to 30 September 1964. They were classified according to their exposure period to famine, namely, no exposure, fetal-, early-, mid-, and late childhood. Multivariate logistic regression and subgroup analysis have been conducted to determine the odds ratio (OR) and confidence intervals (CIs) between famine exposure and LVH.ResultsThis research included 2,543 participants, 1,612 women, their mean age was 59.07 ± 3.65 years, and 704 participants had LVH. LVH prevalence was 122 (23.6%), 87 (25.1%), 133 (27.3%), 184 (29.2%), and 178 (31.7%), in non-, fetal-, early-, mid-, and late-childhood exposed groups, respectively (p = 0.031), while in the non-exposed group, the ORs for developing carotid plaque as a result of fetal, early-, mid- to late-childhood exposure were 1.08 (95% CI: 0.76, 1.59, p = 0.619), 1.24 (95% CI: 1.03, 1.79, p = 0.031), 1.49 (95% CI: 1.10, 2.01, p = 0.009), and 1.64 (95% CI: 1.25, 2.18, p = 0.001), respectively (p for trend = 0.003). There was no interactive effect between gender, obesity, or hypertension history with how the famine influenced LVH, as the subgroups analyses demonstrated (all p for interaction > 0.05).ConclusionThis research has demonstrated the potential relationship between Great Chinese Famine exposure during childhood and LVH in adults.

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“…Although inorganic sulfide salts (NaHS and Na 2 S) have been the most widely employed in biological and preclinical studies, none of them are unlikely to be a suitable clinical option for a number of reasons, including poor water solubility, fast and uncontrollable release, and unpleasant odor. Given that it is not trivial to synthesize a clinically suitable H 2 S donor in a short time, three types of potential H 2 S donors or drugs should be considered to block viral entry: (1) natural H 2 S donors (e.g., garlic and onions) [ 127 , 128 ] or dietary micronutrients (e.g., L-cysteine and taurine) [ 129 , 130 ], (2) H 2 S-donating derivatives of clinically used drugs that link various H 2 S donating groups to clinically used drugs (e.g., ATB-346 [ 131 ] and GIC-1001 [ 132 ] which has completed phase 2 clinical trial), and (3) several clinically used drugs that have been verified to increase H 2 S levels (e.g., α -lipoic acid, [ 133 ] sodium thiosulfate, [ 134 ] zofenoprilat, [ 135 ] and N-acetylcysteine [ 136 ]). Sodium thiosulfate has been proposed as an inhalation therapy for COVID-19, [ 137 ] and it was confirmed that the combined application of N-acetylcysteine improved the symptoms in COVID-19 patient.…”

Section: Discussionmentioning

confidence: 99%

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS‐CoV‐2 and Its Potential Cell Surface Receptors

Dai

Teng

Jin

et al. 2021

Oxidative Medicine and Cellular Longevity

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The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing a great threat to the global economy and public health security. Together with the acknowledged angiotensin-converting enzyme 2, glucose-regulated protein 78, transferrin receptor, AXL, kidney injury molecule-1, and neuropilin 1 are also identified as potential receptors to mediate SARS-CoV-2 infection. Therefore, how to inhibit or delay the binding of SARS-CoV-2 with the abovementioned receptors is a key step for the prevention and treatment of COVID-19. As the third gasotransmitter, hydrogen sulfide (H2S) plays an important role in many physiological and pathophysiological processes. Recently, survivors were reported to have significantly higher H2S levels in COVID-19 patients, and mortality was significantly greater among patients with decreased H2S levels. Considering that the beneficial role of H2S against COVID-19 and COVID-19-induced comorbidities and multiorgan damage has been well-examined and reported in some excellent reviews, this review will discuss the recent findings on the potential receptors of SARS-CoV-2 and how H2S modulates the above receptors, in turn blocking SARS-CoV-2 entry into host cells.

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Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: The role of hydrogen sulfide

Cited by 18 publications

References 54 publications

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

The Relationship Between Famine Exposure During Early Life and Left Ventricular Hypertrophy in Adulthood

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS‐CoV‐2 and Its Potential Cell Surface Receptors

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