Taurine up-regulated 1 accelerates tumorigenesis of colon cancer by regulating miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis in vitro and in vivo

Tian, Li; Zhao, Zhifeng; Xie, Lin; Zhu, Jinpeng

doi:10.1016/j.lfs.2019.117035

Cited by 31 publications

(30 citation statements)

References 20 publications

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“…Similarly, another study identified that knockdown of TUG1 blocks the proliferation of colon cancer cells, and impedes tumor growth in vivo [23]. Mechanistically, TUG1 overexpression elevates p-p38 mitogen-activated protein kinase (p-p38 MAPK), and pheat shock protein 27 (p-Hsp27) levels in colon cancer [23]. LncRNA small nucleolar RNA host gene 7 (SNHG7) is overexpressed in colon advanced adenomas and early-stage colon cancer, and SNHG7 downregulation in HT29 cells retards cell proliferation via interacting with miR-193b and suppressing K-ras/ERK/cyclin D1 [76].…”

Section: Lncrnas Regulate Cell Proliferationmentioning

confidence: 90%

“…Moreover, knockdown of TUG1 suppresses the proliferation of HCT116 and LoVo cells [79]. Similarly, another study identified that knockdown of TUG1 blocks the proliferation of colon cancer cells, and impedes tumor growth in vivo [23]. Mechanistically, TUG1 overexpression elevates p-p38 mitogen-activated protein kinase (p-p38 MAPK), and pheat shock protein 27 (p-Hsp27) levels in colon cancer [23].…”

Section: Lncrnas Regulate Cell Proliferationmentioning

confidence: 96%

“…Emerging evidence has implicated that lncRNAs play vital roles in colon carcinogenesis and progression [17,18], with one study identifying approximately 200 differentially expressed lncRNAs in colon tumors using RNA sequencing data from TCGA dataset [19]. LncRNAs are involved in patient outcome [20], cell proliferation, [21], cell apoptosis [22], cell metastasis and invasion [23], cell cycle [24], epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and drug resistance (Fig. 1).…”

Section: Role Of Lncrnas In Colon Cancermentioning

confidence: 99%

“…LncRNA HULC knockdown inhibits cell migration and invasion by modulating miR-613/RTKN expression in colon cancer cells [48]. Silencing of TUG1 impedes cell invasion in vitro and in mice via regulation of the miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis [23]. Inhibition of ENST00000455974 causes disrupts the migration of colon cancer cells, whereas ENST00000455974 upregulation enhances the metastasis of colon cancer via the upregulation of JAG2 [39].…”

Section: Lncrnas Regulate Invasion and Metastasismentioning

confidence: 99%

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Long noncoding RNAs: functions and mechanisms in colon cancer

2020

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Evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the carcinogenesis and progression of a wide variety of human malignancies including colon cancer. In this review, we describe the functions and mechanisms of lncRNAs involved in colon oncogenesis, such as HOTAIR, PVT1, H19, MALAT1, SNHG1, SNHG7, SNHG15, TUG1, XIST, ROR and ZEB1-AS1. We summarize the roles of lncRNAs in regulating cell proliferation, cell apoptotic death, the cell cycle, cell migrative and invasive ability, epithelial-mesenchymal transition (EMT), cancer stem cells and drug resistance in colon cancer. In addition, we briefly highlight the functions of circRNAs in colon tumorigenesis and progression, including circPPP1R12A, circPIP5K1A, circCTIC1, circ_0001313, circRNA_104916 and circRNA-ACAP2. This review provides the rationale for anticancer therapy via modulation of lncRNAs and circular RNAs (circRNAs) in colon carcinoma.

show abstract

Section: Lncrnas Regulate Cell Proliferationmentioning

confidence: 90%

Section: Lncrnas Regulate Cell Proliferationmentioning

confidence: 96%

Section: Role Of Lncrnas In Colon Cancermentioning

confidence: 99%

Section: Lncrnas Regulate Invasion and Metastasismentioning

confidence: 99%

See 2 more Smart Citations

Long noncoding RNAs: functions and mechanisms in colon cancer

2020

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“…Currently, the traditional therapies, such as chemotherapy [2], surgical resection [3], radiotherapy [4], and combined therapy [5] are used for CRC treatment. Over the past decade, many clinical or experimental studies have provided many fundamental insights into the pathogenesis of CRC [5][6][7]. There are a number of risk factors for CRC reported in published studies, such as diet [8], obesity [9], and alcohol intake [10].…”

Section: Introductionmentioning

confidence: 99%

Low circulating 25-hydroxyvitamin D level is associated with increased colorectal cancer mortality: a systematic review and dose–response meta-analysis

Wu¹,

Xue

Zhao³

et al. 2020

Bioscience Reports

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Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D (25(OH)D) and survival in patients with colorectal cancer (CRC). The aim of this study was to quantitatively assess these associations. PubMed, EMBASE and Web of Science databases were systematically searched for eligible studies. Subgroup analyses based on study geographic location, publication year, length of follow-up time, sample size, and stage were conducted to explore potential sources of heterogeneity. Dose-response relationships and pooled hazard ratios (HR) for overall and CRC-specific survival comparing the highest versus the lowest categories of circulating 25(OH)D concentrations were assessed. Overall, 17 original studies with a total of 17770 CRC patients were included. Pooled HR (95% confidence intervals) comparing highest versus lowest categories were 0.64 (0.55-0.72) and 0.65 (0.56-0.73) for overall and CRC-specific survival, respectively. Studies conducted in the USA, with median follow-up time ≥ 8 years, larger sample size, and including stage I-III patients showed a more prominent association between 25(OH)D concentrations and overall survival. The dose-response analysis showed that the risk of all-cause mortality was reduced by 7% (HR = 0.93; 95% CI: 0.90, 0.95), and the risk of CRC-specific mortality was reduced by 12% (HR = 0.88; 95% CI: 0.84, 0.93) for each 20 nmol/L increment of 25(OH)D concentration. This meta-analysis provides evidences that a higher 25(OH)D concentration is associated with lower overall mortality and CRC-specific mortality.

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LncRNA TUG1 regulates the balance of HuR and miR-29b-3p and inhibits intestinal epithelial cell apoptosis in a mouse model of ulcerative colitis

Tian

Wáng

et al. 2020

Human Cell

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Taurine up-regulated 1 accelerates tumorigenesis of colon cancer by regulating miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis in vitro and in vivo

Cited by 31 publications

References 20 publications

Long noncoding RNAs: functions and mechanisms in colon cancer

Long noncoding RNAs: functions and mechanisms in colon cancer

Low circulating 25-hydroxyvitamin D level is associated with increased colorectal cancer mortality: a systematic review and dose–response meta-analysis

LncRNA TUG1 regulates the balance of HuR and miR-29b-3p and inhibits intestinal epithelial cell apoptosis in a mouse model of ulcerative colitis

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