Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway

Lv, Chaoxiang; Li, Yuanguo; Wang, Tiecheng; Zhang, Qiqi; Qi, Jing; Sima, None Mingwei; Li, Entao; Shi, Zhuangzhuang; Li, Fangxu; Wang, Xuefeng; Sun, Wenzhao; Feng, Na; Wang, Cuiling; Xia, Xianzhu; Jin, Ningyi; Zhou, Yifa; Gao, Yuwei

doi:10.1016/j.virs.2022.11.010

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…NF-κB is a major mediator of proinflammatory cytokines, which can exert antiviral activities [ 204 , 205 ] or mediate pathogenic inflammatory responses [ 206 , 207 ]. Interestingly, many studies have demonstrated a pro-viral role for NF-κB in influenza virus replication [ 208–212 ], specifically in promoting viral RNA replication [ 208 , 209 , 213 , 214 ], suggesting that influenza viruses can convert this antiviral and proinflammatory pathway for viral replication.…”

Section: Host Factors and Cell Signalling Contribute To Viral Replica...mentioning

confidence: 99%

Pathogenicity and virulence of influenza

Liang

2023

Virulence

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Influenza viruses, including four major types (A, B, C, and D), can cause mild-to-severe and lethal diseases in humans and animals. Influenza viruses evolve rapidly through antigenic drift (mutation) and shift (reassortment of the segmented viral genome). New variants, strains, and subtypes have emerged frequently, causing epidemic, zoonotic, and pandemic infections, despite currently available vaccines and antiviral drugs. In recent years, avian influenza viruses, such as H5 and H7 subtypes, have caused hundreds to thousands of zoonotic infections in humans with high case fatality rates. The likelihood of these animal influenza viruses acquiring airborne transmission in humans through viral evolution poses great concern for the next pandemic. Severe influenza viral disease is caused by both direct viral cytopathic effects and exacerbated host immune response against high viral loads. Studies have identified various mutations in viral genes that increase viral replication and transmission, alter tissue tropism or species specificity, and evade antivirals or pre-existing immunity. Significant progress has also been made in identifying and characterizing the host components that mediate antiviral responses, pro-viral functions, or immunopathogenesis following influenza viral infections. This review summarizes the current knowledge on viral determinants of influenza virulence and pathogenicity, protective and immunopathogenic aspects of host innate and adaptive immune responses, and antiviral and pro-viral roles of host factors and cellular signalling pathways. Understanding the molecular mechanisms of viral virulence factors and virus-host interactions is critical for the development of preventive and therapeutic measures against influenza diseases.

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Section: Host Factors and Cell Signalling Contribute To Viral Replica...mentioning

confidence: 99%

Pathogenicity and virulence of influenza

Liang

2023

Virulence

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A comprehensive review of highly pathogenic avian influenza (HPAI) H5N1: An imminent threat at doorstep

Charostad,

Rezaei Zadeh Rukerd,

Mahmoudvand

et al. 2023

Travel Medicine and Infectious Disease

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Comprehensive Theoretical Insights on Spectroscopic Characterization, Solvent Effect (Polar and Nonpolar) in Electronic behavior, Topological Insights, and Molecular Docking Prediction of Taurolidine

2024

Int. Res. J. multidiscip. Technovation

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In recent decades, sulfur-containing compounds have played a significant role in biological applications because of their unique biological and chemical characteristics. Taurolidine, a sulfur-containing derivative of the amino acid taurine, has been characterized theoretically utilizing Density Functional Theory (DFT) at the B3LYP approach along with a 6-311++G(d,p) basis set. The impact of solvents on electronic characteristics, Molecular electrostatic potential (MEP), and Fourier Molecular Orbital (FMO) in polar (water and ethanol) and nonpolar (toluene and chloroform) has been analyzed. The bond distances of S1-C16 and S1-C17 have been simulated at 1.817 Å and observed at 1.743 and 1.739 Å, respectively. These distances are increased compared to other bond distances due to the influence of sulfur atoms. The distinctive simulated vibrational wavenumbers of taurolidine revealed peaks for SO2, CH2, CN, and NH groups. The intramolecular interactions responsible for stabilizing the molecular structure of taurolidine have been addressed using NBO analysis shows significant stabilization energy from electron-donating lone pair oxygen O6 to antibonding S2-N10 with the stabilizing energy of 19.88 KJ/mol by the transition of LP(3)- σ*. The bonding characteristics and reactive sites (electron-rich and electron-poor) have been confirmed with Mulliken and MEP analysis. The carbons (C17 and C16) emphasize the increased negative potential due to the sulfonyl (SO2) group in the ortho position. The topological insights, ELF and LOL, were spotted using Multiwfn software, highlighting the localized and delocalized electron regions within the crystal structure. In addition, molecular docking was performed to predict the antagonist activity of taurolidine against β-catenin protein, yielding a binding energy of -6.86 KJ/mol, which confirms its antiproliferative property.

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Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway

Cited by 3 publications

References 39 publications

Pathogenicity and virulence of influenza

Pathogenicity and virulence of influenza

A comprehensive review of highly pathogenic avian influenza (HPAI) H5N1: An imminent threat at doorstep

Comprehensive Theoretical Insights on Spectroscopic Characterization, Solvent Effect (Polar and Nonpolar) in Electronic behavior, Topological Insights, and Molecular Docking Prediction of Taurolidine

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