Tavşanlarda Tarantula Cubensis Ekstraktı ve Düşük Enerjili Lazer Uygulanan Deneysel Kemik Defektlerinin İyilesmesinde Osteonektin ve Ostekalsinin Etkilerinin Araştırılması

Altan, Semih

doi:10.47027/duvetfd.815371

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…[ 9 ] In addition, it has been reported that applications of Theranekron in bone defect models in rabbits may have important potential in promoting early bone healing. [ 10 , 11 ]…”

Section: Introductionmentioning

confidence: 99%

“…[9] In addition, it has been reported that applications of Theranekron in bone defect models in rabbits may have important potential in promoting early bone healing. [10,11] To the best of our knowledge, there is no study examining the effect of Theranekron, which has been used in many studies in recent years, on a bone fracture model in the literature. In the present study, we, therefore, aimed to investigate the radiological, biomechanical, histopathological, and immunohistochemical effects of Theranekron on fracture healing in a rat model.…”

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confidence: 99%

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The effect of Theranekron on femur fracture healing in an experimental rat model

Güven

Özkan²,

Türközü³

et al. 2022

Jt Dis Relat Surg

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Objectives The aim of this study was to investigate the radiological, biomechanical, histopathological and immunohistochemical effects of Theranekron on fracture healing in an experimental rat model. Materials and methods Forty-eight male albino Wistar rats were used. Four groups were formed, with 12 rats in each of Theranekron groups 1 and 2, and control groups 1 and 2. After a fracture was created in the right femur of the rats included in the study, fixation was performed with an intramedullary Kirschner wire. Theranekron was administered subcutaneously to Theranekron groups 1 and 2 at a dose of 0.3 mg/kg on days 0, 5 and 10. After radiographic analysis of the femurs of Theranekron group 1 and control group 1 rats at four weeks of the study was performed, both groups were divided into two equal subgroups (six femurs in each group). Histopathological and immunohistochemical examinations were performed in one subgroup and biomechanical examination in the other subgroup. At the end of six weeks, the rats in Theranekron group 2 and control group 2 were evaluated after applying the same procedure as in the fourth week. Results When the mean radiological scores of the Theranekron and control groups were compared, a statistically significant difference was found in favor of the Theranekron group at four and six weeks (p=0.028 and p=0.006, respectively). At four weeks, statistically significant higher biomechanical forces were obtained in the Theranekron group compared to the control group (p=0.030). In the histopathological evaluation, the inflammation value of the control group at four weeks was statistically significantly higher than the Theranekron group (p=0.027). The angiogenesis, osteoblast proliferation, and bone formation values of the Theranekron group were significantly higher than the control group (p=0.014, p=0.014, and p=0.005, respectively). At six weeks, the bone formation values of the Theranekron group were statistically significantly higher than the control group (p=0.021). The difference between the Theranekron group and the control group scores of the immunohistochemical evaluation were statistically significantly different at four and six weeks (p=0.006 and p=0.011, respectively). Conclusion Theranekron may play a role in accelerating fracture healing by reducing acute inflammation process in the early period of fracture union, increasing fracture strength, angiogenesis, osteoblast proliferation, and bone formation.

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“…[ 9 ] In addition, it has been reported that applications of Theranekron in bone defect models in rabbits may have important potential in promoting early bone healing. [ 10 , 11 ]…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

The effect of Theranekron on femur fracture healing in an experimental rat model

Güven

Özkan²,

Türközü³

et al. 2022

Jt Dis Relat Surg

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Biogenic selenium nanoparticles: their dual impact on spleen and growth in arthritic mice

Qamar,

John

2024

JOBM

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Selenium is known to be an important element for growth and splenic microenvironment regulation. About 5–10% of RA patients presented enlarged spleen along with low levels of selenium than the normal individuals. The current study aims to determine the effects of biogenic selenium nanoparticles (SeNPs) on the growth and spleen of healthy and arthritic mice. Biogenic SeNPs were evaluated for their adverse as well as therapeutic effects on the growth rate and splenic integrity of healthy and arthritic Balb/c mice. The tested doses of SeNPs significantly reduced the growth of mice along with splenomegaly in biosafety profiling while the treatment revealed dose-independent improvement in the growth of arthritic mice as compared to untreated arthritic control with no adverse effect on spleen. Concluding, selenium levels directly affect the growth of mice with no harm to splenic integrity in arthritic mice, however further investigation is required to develop a new method for evaluating the efficacy of Se sources.

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Tavşanlarda Tarantula Cubensis Ekstraktı ve Düşük Enerjili Lazer Uygulanan Deneysel Kemik Defektlerinin İyilesmesinde Osteonektin ve Ostekalsinin Etkilerinin Araştırılması

Cited by 2 publications

References 36 publications

The effect of Theranekron on femur fracture healing in an experimental rat model

The effect of Theranekron on femur fracture healing in an experimental rat model

Biogenic selenium nanoparticles: their dual impact on spleen and growth in arthritic mice

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