Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats

Abstract

Objective: To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in rats. Methods: A total of 18 female Wistar albino rats were randomly and equally divided into three groups: the sham group, the ovarian ischemia reperfusion group, and the 50 mg/kg taxifolin+ovarian ischemia reperfusion group. The ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion protocol. Biochemical and histopathologic examinations were performed on the extracted ovaries. Results: Levels of malondialdehyde and cyclooxygenase-2 were increased, while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion group. However, these values were reversed in the taxifolin+ovarian ischemia reperfusion group. Similarly, the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group, while they were within normal range in the taxifolin+ovarian ischemia reperfusion group. Conclusions: Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury, and taxifolin may be useful for protecting ovarian tissue from such injury.

Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats

“…A higher concentration of androgen may occasion deterioration of follicles by increasing the number of pycnotic granulosa cells and degenerating oocytes. 50,61 In addition, edema, cell degeneration, hemorrhage, and vascular congestion in the PCOS group’s ovarian tissues suggest prooxidant and proinflammatory ovarian tissue lesions. In this sense, there is a statistically significant injury in the PCOS group compared to the control and PCOS+CES in cell degeneration, vascular congestion, and interstitial edema, and hemorrhage results obtained in these histopathological examinations.…”

Tocilizumab is effective in preventing ovarian injury induced by ischemia- reperfusion in rats

“…In a previous experimental study, this dose of tocilizumab protected nerve tissues from oxidant and proinflammatory cytokine damage (Abdelrahman et al 2019). We chose a 2-h duration of torsion based on the study of Kiremitli et al (Kiremitli et al 2021).…”