Taxol promising fungal endophyte, Pestalotiopsis species isolated from Taxus cuspidata

Kumaran, Rangarajulu Senthil; Kim, Hyung Joo; Hur, Byung‐Ki

doi:10.1016/j.jbiosc.2010.06.007

Cited by 100 publications

(36 citation statements)

References 22 publications

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“…[259] [263] Pestalotiopsis terminaliae T. arjuna [264] Pestalotiopsis versicolor T. cuspidata [262] Pezicula sp. T. chinensis [223] Phoma betae G. biloba [265] Phyllosticta melochiae Melochia corchorifolia [267] Phyllosticta sp.…”

Section: W Nobilis Catharanthus Roseusunclassified

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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Section: W Nobilis Catharanthus Roseusunclassified

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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“…54,57 Fungi such as Taxomyces andreanae, Pestalotiopsis microspora, Tubercularia sp., Phyllosticta citricarpa, Nodulisporium sylviforme, Colletotrichum gloeosporoides, Colletotrichum annutum, Fusarium maire and Pestalotiopsis versicolor produce it. 54,[58][59][60][61][62][63][64] The endophyte F. maire produces 225 μg l − 1 . Production by P. citricarpa amounted to 265 μg l − 1 .…”

Section: Antineoplastic Drugsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

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“…Recently, several reports have been published claiming that endophytic fungi contain genes previously identified in Taxus spp. that encode the corresponding pathway enzymes (Zhang et al 2008;Staniek et al 2009;Miao et al 2009;Kumaran et al 2010). The publication of Stierle and colleagues also resulted in a huge proliferation of studies of endophytes from Taxus species (Rivera-Orduña et al 2011) and other medicinal plants (Kumar and Hyde 2004;Huang et al 2009;Lin et al 2010) as it generally became accepted that horizontal gene transfer was commonplace and that fungal endophytes within these plants could probably also produce the bioactive medicinal compounds produced by the plants (Chandra 2012).…”

Section: Introductionmentioning

confidence: 99%

Getting to the bottom of Taxol biosynthesis by fungi

2013

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Taxol (paclitaxel) is a highly-oxygenated diterpenoid natural product first isolated from the pacific yew tree (Taxus brevifolia). It is one of the most widely used anticancer drugs. Soon after the discovery of its unique mode of action and the resulting high demand, an extensive search was initiated for alternative sources to replace the slow-growing and scarce pacific yew. Thus far, however, Taxol and related compounds have only been found in the genus Taxus, which comprises a small number of slow-growing plants with a broad but generally isolated geographical distribution. In 1993, Stierle and colleagues reported the independent biosynthesis of Taxol in an endophytic fungus isolated from Taxus brevifolia, which resulted in more than 160 subsequent publications and patents addressing the biosynthesis of Taxol and related taxanes by microorganisms. The literature on fungal taxane synthesis contains numerous inconsistencies, prompting us to thoroughly re-examine Taxol biosynthesis in endophytic fungi associated with Taxus spp. Using a combination of phytochemistry, molecular biology and genome sequencing, we were unable to find any evidence for independent taxane biosynthesis in any of the endophytes, including the isolate described in the original publication (Taxomyces andreanae) and several more recent isolates from Taxus trees. Our findings therefore resolve a long-standing mystery concerning the evolution of a complex terpenoid biosynthetic pathway in two distantly-related organisms.

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Taxol promising fungal endophyte, Pestalotiopsis species isolated from Taxus cuspidata

Cited by 100 publications

References 22 publications

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Production of valuable compounds by molds and yeasts

Getting to the bottom of Taxol biosynthesis by fungi

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