Taxonomic Distribution of Neoplasia among Non-Domestic Felid Species under Managed Care

Moresco, Anneke; Muñoz, Karina E; Gutiérrez, Federico H.; Arias-Bernal, Leonardo; Yarto-Jaramillo, Enrique; Teixeira, Rodrigo Hidalgo Friciello; Peña-Stadlin, Juliana; Troan, Brigid V.

doi:10.3390/ani10122376

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…High cancer risk in managed populations of Carnivora has previously been reported 23,24 . Possible explanations include the use of hormonal contraception (for example, progestins) and pregnancy postponement in zoo carnivores, both being significant risk factors for certain cancers in humans as well as non-domestic felids [24][25][26] .…”

Section: Cancer Across the Mammalian Phylogenymentioning

confidence: 92%

“…Pairwise comparison between sexes revealed no sex bias in either measure of cancer mortality risk (phylogenetic paired t -tests, CMR: t = 0.52, df = 33, P = 0.6061; ICM: t = −0.6815, df = 27, P = 0.5014) (ref. 23 ). Therefore, the generally high cancer risk in Carnivora is unlikely to be driven solely by the carcinogenic effects of reproductive management in zoo populations.…”

Section: Cancer Across the Mammalian Phylogenymentioning

confidence: 99%

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Cancer risk across mammals

Vincze

Colchero

Lemaître

et al. 2021

Nature

148

173

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Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations1,2. While elevated cancer risk with larger body size and/or longevity has been documented within species3–5, Peto’s paradox indicates the apparent lack of such an association among taxa6. Yet, unequivocal empirical evidence for Peto’s paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto’s paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.

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Section: Cancer Across the Mammalian Phylogenymentioning

confidence: 92%

Section: Cancer Across the Mammalian Phylogenymentioning

confidence: 99%

Cancer risk across mammals

Vincze

Colchero

Lemaître

et al. 2021

Nature

148

173

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“…It has been suggested that there may be a genetic predisposition/propensity for the development of neoplasia at the Panthera genus (or higher) level, which may be compounded by mutations from in‐breeding in captive populations (Moresco et al., 2020). In a study of 195 cases of neoplasia in 16 species of non‐domesticated felid species living under managed care (80 and 115 cases of Pathera and non‐ Panthera species, respectively), the Panthera species had a significantly higher prevalence of neoplasia than non‐ Panthera species (50% vs. 13%, respectively), with the percentage of malignant neoplasms also significantly higher in the Panthera species (86% vs. 61% respectively) (Moresco et al., 2020). The reproductive system (reproductive organs and mammary glands) was the most commonly affected system (21% of cases), followed by the haematolymphoid system (18%) and the respiratory system (16%) (Moresco et al., 2020), with only one case involving the urinary system (UC of the urinary bladder in a lion).…”

Section: Discussionmentioning

confidence: 99%

“…In a study of 195 cases of neoplasia in 16 species of non‐domesticated felid species living under managed care (80 and 115 cases of Pathera and non‐ Panthera species, respectively), the Panthera species had a significantly higher prevalence of neoplasia than non‐ Panthera species (50% vs. 13%, respectively), with the percentage of malignant neoplasms also significantly higher in the Panthera species (86% vs. 61% respectively) (Moresco et al., 2020). The reproductive system (reproductive organs and mammary glands) was the most commonly affected system (21% of cases), followed by the haematolymphoid system (18%) and the respiratory system (16%) (Moresco et al., 2020), with only one case involving the urinary system (UC of the urinary bladder in a lion). Prior to the case presented here, it was the only reported case of UC in a member of the Panthera species, consistent with the rarity of reports of UC of the urinary bladder in non‐domestic felids, having been reported in fishing cats (Sutherland‐Smith et al., 2004), and a Pallas’ cat (Moresco et al., 2020), and the relatively low incidence of UC in domestic cats.…”

Section: Discussionmentioning

confidence: 99%

“…Urothelial carcinoma (UC; formerly known as transitional cell carcinoma) is the most common type of bladder cancer in dogs and cats, although the incidence in cats is comparatively low (∼2% versus 0.38–0.56% of all malignancies, respectively) (Meuten & Meuten, 2017; Shida et al., 2010; Wimberly & Lewis, 1979). UC has rarely been reported in non‐domesticated felids, with cases mentioned only in captive‐bred fishing cats (Prionailurus viverrinus) (Sutherland‐Smith et al., 2004), a Pallas’ cat ( Otocolobus manul ) and a lion ( Panthera leo ) (Moresco et al., 2020). In a recent study of neoplasia in captive Panthera species, which included 70 tigers and a total of 108 neoplasms, there was only one report of a neoplasia in the urinary system, specifically a renal papillary adenoma (Kloft et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

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Metastatic urothelial carcinoma of the urinary bladder in a Sumatran tiger (Panthera tigris sondaica)

Weyden

Tibbs²,

Knott³

et al. 2022

Veterinary Medicine & Sci

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A 15‐year‐old spayed female Sumatran tiger (Panthera tigris sondaica) was presented with a short history of haematuria and dysuria, non‐responsive to antibiotics, and a gradual decline to inappetence over a period of 2–3 months. Ultrasound examination showed a thickened urinary bladder wall and the renal pelvis of right kidney was dilated and cystic. A presumptive diagnosis of renal failure was made, and the tigress was euthanised due to deteriorating quality of life and pronounced weight loss. Histopathology revealed extensive erosion of the urinary bladder wall and marked congestion of the submucosal vasculature, a potential cause of the haematuria observed clinically. Numerous foci of neoplastic cells were also observed throughout the lung parenchyma as well as within lymphatic vessels of the lung, the liver and the kidney. A diagnosis of a metastatic non‐papillary high‐grade urothelial carcinoma (UC) of the urinary bladder was made. Consistent with this diagnosis, immunohistochemistry revealed the neoplastic cells were negative for uroplakin III, as has been reported for a subset of high‐grade, infiltrative urinary bladder UCs of canines and humans. This is the first report of a primary tumour of the urinary bladder in a tiger and the first report of UC in a tiger.

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