Four new species of the strophocheilid genus Anthinus are described from Brazil, being A. synchondrus from region of Unaí, Minas Gerais; A. vailanti from the region of Brasilândia de Minas, Minas Gerais; A. morenus from Paracatu region, Minas Gerais; and A. savanicus from Formosa region, Goiás. Another similar snail from Itacarambi, Minas Gerais, is described as a new genus and species: Catracca uhlei. All species are described conchologically and anatomically, with distinctions explored in almost all structures. For comparative purposes, a similar anatomical investigation on the Anthinus type species, A. multicolor, from Rio de Janeiro, is also performed. A detailed comparative analysis and discussion is provided, including taxonomic and initial phylogenetic inferences. The preliminary phylogenetic analysis is based on anatomically known species in the literature and in the presently study. A bulimulid, a simpulopsid and two dorcasiids are outgroups. The preliminary cladogram already shows a monophyletic Strophocheilidae (14 synapomorphies), divided into two also monophyletic subfamilies: Megalobuliminae (14 synapomorphies) and Strophocheilinae (5 synapomorphies). The new Catracca resulted as the most basal strophocheilid branch. Mirinaba and Anthinus were also supported as monophyletic (3 and 6 synapomorphies respectively. Register ZooBank: urn:lsid:zoobank.org:pub:FC4DD323-EF6A-404B-9755-F124F9DBB6D4.