Taxonomy and anticancer potential of Streptomyces niphimycinicus sp. nov. against nasopharyngeal carcinoma cells

Huang, Yiying; Hu, Wenjin; Huang, Shushi; Chu, Jiemei; Liang, Yushan; Tao, Zhanhua; Wang, Guiwen; Zhuang, Junlian; Zhang, Zhe; Zhang, Xiaoxin; Pan, Xinli

doi:10.1007/s00253-023-12707-w

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…IMB7-145 and 255, 257 and 258 displayed antibacterial effects on MRSA and vancomycin-resistant enterococci (VRE) with MIC values of 8-64 µg/mL [142]. Moreover, compound 255 exhibited significant anti-M. tuberculosis activity (MIC = 32 µg/mL) and significantly inhibited the growth of the phytopathogenic fungus Fusarium oxysporum f. sp.cubense (EC 50 = 1.20 µg/mL) as well as demonstrating cytotoxic activity against nasopharyngeal carcinoma cell lines TW03 and 5-8F (IC 50 = 12.24 µg/mL and 9.44 µg/mL, respectively) [143,144]. The increase in malonyl substituents had a negative effect on its biological activity.…”

Section: Miscellaneous Alkaloidsmentioning

confidence: 99%

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Liu,

Sun,

et al. 2024

Marine Drugs

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Natural alkaloids originating from actinomycetes and synthetic derivatives have always been among the important suppliers of small-molecule drugs. Among their biological sources, Streptomyces is the highest and most extensively researched genus. Marine-derived Streptomyces strains harbor unconventional metabolic pathways and have been demonstrated to be efficient producers of biologically active alkaloids; more than 60% of these compounds exhibit valuable activity such as antibacterial, antitumor, anti-inflammatory activities. This review comprehensively summarizes novel alkaloids produced by marine Streptomyces discovered in the past decade, focusing on their structural features, biological activity, and pharmacological mechanisms. Future perspectives on the discovery and development of novel alkaloids from marine Streptomyces are also provided.

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Section: Miscellaneous Alkaloidsmentioning

confidence: 99%

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Liu,

Sun,

et al. 2024

Marine Drugs

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“…In order to find novel molecular structures, several different strategies are being followed, from manipulating the genome to forcing the expression of cryptic clusters (genome mining) [22] or looking for new strains in barely explored environments such as the Earth's poles, insect teguments, high altitudes, caves or marine sources [20,[23][24][25][26][27]. Several different cytotoxic compounds have been recently isolated from Streptomyces [28][29][30][31] In this work, we isolated microorganisms from marine sediments in Indonesia. One of the strains isolated was a bacterium from the genus Streptomyces.…”

mentioning

confidence: 99%

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Ceniceros,

Cañedo,

Méndez

et al. 2023

Metabolites

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Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment. Structural elucidation of the three compounds showed they belong to the nonribosomal peptides family, and they all contain an acylated alanine, three piperazic acids, a methylated glycine, and an N-hydroxylated alanine. The difference between the three compounds resides in the acyl chain bound to the alanine residue. All three compounds showed cytotoxic activity against human cancer cell lines. Genome sequence and bioinformatics analysis allowed the identification of the gene cluster responsible for the biosynthesis. Inactivation of a nonribosomal peptide synthase of this cluster abolished the biosynthesis of the three compounds, thus demonstrating the involvement of this cluster in the biosynthesis of these lipopeptides.

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Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Liu,

Sun,

et al. 2023

Preprint

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Natural alkaloids of actinomycetes origin and synthetic derivatives have always been among the important suppliers of small-molecule drugs. Among their biological sources, Streptomyces is the highest and most extensively researched genus. Marine-derived Streptomyces strains harbor unconventional metabolic pathways and have been demonstrated to be efficient producers of biologically active alkaloids since more than 60% of these compounds exhibit valuable activity such as antibacterial, antitumor, anti-inflammatory activity, etc. This review comprehensively summarizes novel alkaloids produced by marine Streptomyces discovered in the past decade, focusing on their structural features, biological activity and pharmacological mechanisms. Future perspectives on the discovery and development of novel alkaloids from marine Streptomyces are also provided.

show abstract

Taxonomy and anticancer potential of Streptomyces niphimycinicus sp. nov. against nasopharyngeal carcinoma cells

Cited by 3 publications

References 51 publications

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

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