Fermentation engineering is a technology that uses engineering technology to produce useful biological products for human beings by using certain functions of organisms (mainly microorganisms) and active isolated enzymes, or to directly control certain industrial production processes with the participation of microorganisms. With the progress of science and technology, fermentation technology has also developed greatly, and has entered the stage of modern fermentation engineering that can artificially control and modify microorganisms to make these microorganisms produce products for human beings. As an important part of modern biotechnology, modern fermentation engineering has a broad application prospect. The grain fermentation process quality evaluation is a classical MADM issues. In such paper, the generalized weighted Bonferroni mean (WBM) operator is constructed for MADM with single-valued neutrosophic sets (SVNSs). Then, the generalized single-valued neutrosophic number WBM (GSVNNWBM) operator is built and then the MADM decision methods are proposed based on the GSVNNWBM operator. Finally, an example about grain fermentation process quality comprehensive evaluation and some comparative analysis were given to demonstrate the GSVNNWBM method.