Tayside–Fife clinical trial of cognitive–behavioural therapy for medication-resistant psychotic symptoms

Durham, Robert C.; Guthrie, Moyra; Morton, R. Victor; Reid, David A.; Treliving, Linda; Fowler, David; Macdonald, Ranald R.

doi:10.1192/bjp.182.4.303

Cited by 142 publications

(144 citation statements)

References 24 publications

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“…In this exploratory trial, the power calculation was based on the aim to detect a moderate to large effect size, comparable to effects in published trials on other forms of psychotherapy for persistent symptoms of schizophrenia (Kuipers et al 1997 ;Durham et al 2003). A trial with a total sample of 40-60 patients would provide 55 % power of detecting an effect size of 0 .…”

Section: Sample Sizementioning

confidence: 99%

Effect of body-oriented psychological therapy on negative symptoms in schizophrenia: a randomized controlled trial

2006

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Background. In order to improve the treatment of medication-resistant negative symptoms in schizophrenia, new interventions are needed. Neuropsychological considerations and older reports in the literature point towards a potential benefit of body-oriented psychological therapy (BPT). This is the first randomized controlled trial specifically designed to test the effectiveness of manualized BPT on negative symptoms in chronic schizophrenia.

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Section: Sample Sizementioning

confidence: 99%

Effect of body-oriented psychological therapy on negative symptoms in schizophrenia: a randomized controlled trial

2006

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“…CBT has been found to be superior to waiting list control, 59 structured activity and informal support, 60,61 routine care/treatment as usual (TAU), 62,66,67 supportive counselling and routine care, 63 supportive therapy in combination with clozapine, 64 befriending (BF) 65 and supportive psychotherapy (SP). 66 Table 60 (Appendix 1) shows the basic design, participants, outcomes and follow-up periods of trials of RCTs involving CBT for patients diagnosed with schizophrenia or similar condition, who had been followed up for longer than 12 months post-randomisation. A total of 23 papers describing 11 RCTs involving the comparison of CBT with at least one other treatment condition, involving a total of 1175 participants with a diagnosis of schizophrenia or similar, were identified.…”

Section: Schizophreniamentioning

confidence: 99%

“…[59][60][61][62][63][64][65][66][67] All these trials have involved providing CBT in conjunction with antipsychotic medication. CBT has been found to be superior to waiting list control, 59 structured activity and informal support, 60,61 routine care/treatment as usual (TAU), 62,66,67 supportive counselling and routine care, 63 supportive therapy in combination with clozapine, 64 befriending (BF) 65 and supportive psychotherapy (SP). 66 Table 60 (Appendix 1) shows the basic design, participants, outcomes and follow-up periods of trials of RCTs involving CBT for patients diagnosed with schizophrenia or similar condition, who had been followed up for longer than 12 months post-randomisation.…”

Section: Schizophreniamentioning

confidence: 99%

“…A full description of the trial method can be found in the original report. 66 In the original trial patients receiving CBT had shown greater improvement in overall symptom severity than those receiving either SP or TAU, and the CBT and SP groups had shown greater improvement in severity of delusions over the TAU group.…”

mentioning

confidence: 99%

“…Trial 9 -schizophrenia, schizo-affective disorder or delusional disorder, Tayside and Fife 66 Trial 9 was a collaborative study, carried out by two adjacent mental health services in Tayside and Fife. The original trial was conducted between 1997 and 2001.…”

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confidence: 99%

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Long-term outcome of cognitive behaviour therapy clinical trials in central Scotland

Durham

Chambers²,

Power³

et al. 2005

Health Technol Assess

110

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Cognitive behaviour therapy for schizophrenia

Cormac

Jones

Campbell³

2004

Cochrane Database of Systematic Reviews

178

108

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Background The National Institute for Health and Care Excellence (NICE) recommends that Cognitive Behaviour Therapy for psychosis (CBTp) is offered to all patients with a psychosis diagnosis. However, only a minority of psychosis patients in England and Wales are offered CBTp. This is attributable, in part, to the resource-intensive nature of CBTp. One response to this problem has been the development of CBTp in brief formats that are targeted at a single symptom and the mechanisms that maintain distress. We have developed a brief form of CBTp for distressing voices and reported preliminary evidence for its effectiveness when delivered by highly trained therapists (Clinical Psychologists). This study will investigate the delivery of this intervention by a cost-effective workforce of Assistant Psychologists following a brief training and evaluate the acceptability and feasibility of conducting a future, definitive, randomised control trial (RCT). Methods This is a feasibility study for a pragmatic three-arm parallel group superiority 1:1:1 RCT comparing a Guided self-help CBT intervention for voices and treatment as usual (GiVE) to Supportive Counselling and treatment as usual (SC) to Treatment as usual alone (TAU), recruiting across two sites, with blinded post-treatment and follow-up assessments. A process evaluation will quantitatively and qualitatively explore stakeholder experience. Discussion Expected outcomes will include an assessment of the feasibility of conducting a definitive RCT and data to inform the calculation of its sample size. If evidence from a subsequent fully powered RCT suggests that GiVE is clinically and cost effective when delivered by briefly trained Assistant Psychologists, CBTp offered in these less resource-intensive forms has the potential to generate benefits for individual patients (reduced distress, enhanced recovery and enhanced quality of life), service-level patient benefit (increased access to evidence-based psychological therapies) and economic benefits to the NHS (in terms of the reduced use of mental health inpatient services). Administrative Information Increasing access to CBT for psychosis patients: a feasibility, randomized co 4 Title {1} evaluating brief, targeted CBT for distressing voices delivered by Assistant (GiVE2) Trial registration {2a and 2b}. Current Controlled Trials ISRCTN registration number: 16166070.

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Tayside–Fife clinical trial of cognitive–behavioural therapy for medication-resistant psychotic symptoms

Cited by 142 publications

References 24 publications

Effect of body-oriented psychological therapy on negative symptoms in schizophrenia: a randomized controlled trial

Effect of body-oriented psychological therapy on negative symptoms in schizophrenia: a randomized controlled trial

Long-term outcome of cognitive behaviour therapy clinical trials in central Scotland

Cognitive behaviour therapy for schizophrenia

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