Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks

Weinstein, Gerald D.; Koo, John; Krueger, Gerald G.; Lebwohl, Mark; Lowe, Nicholas J.; Menter, M. Alan; Lew‐Kaya, Deborah A.; Sefton, John; Gibson, John R.; Walker, Patricia S.

doi:10.1067/mjd.2003.103

Cited by 111 publications

(83 citation statements)

References 10 publications

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“…These studies showed that as early as at week 1, tazarotene 0.1% formulation showed a statistically significant improvement as compared to the vehicle, with the 0.05% tazarotene formulations showing statistically significant improvement at week 4. Twelve weeks after the discontinuation of therapy (post-treatment phase), both 0.1% and 0.05% tazarotene cream were significantly better as compared to the vehicle (Weinstein et al, 2003). Comparative studies between calcipotriol and tazarotene monotherapy have been carried out, showing superior efficacy of calcipotriol during the first 8 weeks but equal efficacy after 12 weeks' treatment (Tzung et al, 2005).…”

Section: Retinoidsmentioning

confidence: 99%

“…The efficacy of once-daily topical tazarotene has been studied in four randomized, double or single blinded clinical trials; two trials on the tazarotene gel formulation (Lebwohl et al, 1998;Weinstein et al, 1997) and two trials on tazarotene cream formulation (Weinstein et al, 2003) in patients at least 18 years old and having plaque psoriasis in at least 2% of the total body surface area. The duration of active treatment was 12 weeks and an additional 12 weeks follow-up period without active treatment was incorporated in these studies.…”

Section: Retinoidsmentioning

confidence: 99%

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Topical Therapies for Psoriasis

Mitra¹,

Atillasoy²

2012

Psoriasis

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Section: Retinoidsmentioning

confidence: 99%

Section: Retinoidsmentioning

confidence: 99%

Topical Therapies for Psoriasis

Mitra¹,

Atillasoy²

2012

Psoriasis

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“…Furthermore, two vehicle-controlled phase 3 studies have indicated beneficial effects in terms of antipsoriatic efficacy and safety for tazarotene 0.05 and 0.1% as cream formulations [13]. In order to establish more acceptable patient tolerability, tazarotene is optimally used by daily application in combination with glucocorticoids or other treatment options such as UVB and PUVA phototherapy.…”

Section: Treatment Strategiesmentioning

confidence: 99%

Tazarotene: Therapeutic Strategies in the Treatment of Psoriasis, Acne and Photoaging

Roeder

Schaller

Schäfer‐Korting

et al. 2004

Skin Pharmacol Physiol

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Tazarotene is a member of the new generation of receptor-selective, synthetic retinoids for the topical treatment of mild to moderate plaque psoriasis, acne vulgaris and photoaging. Though they are effective in monotherapy, clinical studies with a focus on novel combination treatments and a comparison of different agents for these skin disorders are accumulating. The concomitant use of tazarotene with a mid-potency or high-potency corticosteroid enhances the efficacy in psoriatic plaques and reduces the risk of steroid-induced skin atrophy. Combining phototherapy with adjunctive tazarotene accelerates the clinical response and reduces the cumulative UVB or PUVA exposure load. Tazarotene applied once daily is superior to adapalene monotherapy in acne vulgaris and is efficacious in the treatment of photodamage. Novel therapeutic regimens such as short-contact therapy have been developed for both acne and psoriasis in order to diminish the major adverse events like pruritus, burning, local skin irritation and erythema.

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“…[17][18][19][20][21][22][23][24][25][26][27] Topical Steroids. Topical steroids have been the mainstays of treatment for many years.…”

Section: Topical Therapiesmentioning

confidence: 99%

“…A topical retinoid, tazarotene (Zorac®), also improves chronic plaque psoriasis. 19 The authors of one RCT 20 found tazarotene to be as effective as topical steroids, with a treatment success rate at 12 weeks for knee and elbow lesions of 65 percent with tazarotene 0.1% versus 66 percent with fluocinonide. In a second RCT, 21 tazarotene 0.1% plus a steroid was more effective and better tolerated than tazarotene alone.…”

mentioning

confidence: 99%

Chronic Plaque Psoriasis

Luba

Stulberg

2006

South African Family Practice

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Chronic plaque psoriasis, the most common form of psoriasis, is a papulosquamous disease defined by erythematous plaques with a silvery scale. The diagnosis usually is clinical, but occasionally a biopsy is necessary. Psoriasis affects 0.6 to 4.8 percent of the U.S. population, and about 30 percent of affected patients have a first-degree relative with the disease. Psoriasis is a T-cell-mediated autoimmune disease, but certain medications and infections are well-known risk factors. Management of psoriasis includes education about chronicity, realistic expectations, and use of medication. Steroids and vitamin D derivatives (e.g., calcipotriene) are the mainstays of topical therapy. Topical steroids and calcipotriene together may work better than either agent alone. Patients with psoriasis involving more than 20 percent of their skin or those not responding to topical therapy are candidates for light therapy; traditional systemic therapy; or systemic treatment with immunomodulatory drugs such as alefacept, efalizumab, and etanercept.Reprinted from American Family Physician

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Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks

Cited by 111 publications

References 10 publications

Topical Therapies for Psoriasis

Topical Therapies for Psoriasis

Tazarotene: Therapeutic Strategies in the Treatment of Psoriasis, Acne and Photoaging

Chronic Plaque Psoriasis

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