TB or Not TB

Heller, Israel; Biner, Simon; Isakov, Aharon; Kornitzky, Yulia; Shapira, Itzhak; Marmor, Sylvia; Topilsky, M

doi:10.1378/chest.120.2.674

Cited by 16 publications

(10 citation statements)

References 14 publications

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“…Possible pulmonary lesions included unilateral or bilateral patchy consolidations in subpleural or peribronchial distribution, multiple nodules, single nodule, or mass, etc. All of them may be with or without air bronchograms, cavitations, or reverse halo sign [8,[26][27][28][29][30][31][32]. However, in our opinion, at least half of all cases could be diagnosed much earlier if diagnosed properly.…”

Section: Discussionmentioning

confidence: 86%

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Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

et al. 2011

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Section: Discussionmentioning

confidence: 86%

“…OP is often found in association with non-resolving infectious pneumonia [3]. However, in clinical practice, it is not easy to distinguish between OP and non-resolving infectious pneumonia [6][7][8]. Moreover, OP may be related to lymphoma [9] or carcinoma [10].…”

Section: Introductionmentioning

confidence: 99%

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

et al. 2011

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“…Plain radiograph findings include the following:[72632105–108] Bilateral or unilateral patchy alveolar airspace consolidation is revealed, often subpleural and peribronchial in location and mainly in the lower zones.Generally, the infiltrates gradually enlarge from their original size or new infiltrates appear.Consolidation is often nonsegmental and varies from 2 to 6 cm in diameter.Cavitary BOOP that mimics tuberculosis and cavitating opacity after lung transplantation has been reported.An air bronchogram may be present.Nodules 3-5 mm in diameter are seen in approximately one half of patients; nodules may be migratory.Basal linear opacities are linked to a poorer prognosis.Unilateral focal or lobar consolidation occurs in 5-31% of patients.Miliary pattern is rare.Pleural thickening occurs but pleural effusions are rare.…”

Section: Imaging Findingsmentioning

confidence: 99%

“…HRCT findings have been well described in BOOP[426–286872108–127]: Neither conventional radiographs nor CT findings are specific to BOOP and are seen in a variety of lung-infective, inflammatory and neoplastic processes. However, CT is more sensitive than chest radiography in the assessment of disease pattern and distribution of disease.…”

Section: Hrctmentioning

confidence: 99%

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Bronchiolitis obliterans organizing pneumonia: Pathogenesis, clinical features, imaging and therapy review

et al. 2008

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Bronchiolitis obliterans organizing pneumonia (BOOP) was first described in the early 1980s as a clinicopathologic syndrome characterized symptomatically by subacute or chronic respiratory illness and histopathologically by the presence of granulation tissue in the bronchiolar lumen, alveolar ducts and some alveoli, associated with a variable degree of interstitial and airspace infiltration by mononuclear cells and foamy macrophages. Persons of all ages can be affected. Dry cough and shortness of breath of 2 weeks to 2 months in duration usually characterizes BOOP. Symptoms persist despite antibiotic therapy. On imaging, air space consolidation can be indistinguishable from chronic eosinophilic pneumonia (CEP), interstitial pneumonitis (acute, nonspecific and usual interstitial pneumonitis, neoplasm, inflammation and infection). The definitive diagnosis is achieved by tissue biopsy. Patients with BOOP respond favorably to treatment with steroids.

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Two cases of cryptogenic organizing pneumonia masquerading as tuberculosis (TB) in a TB endemic area

Hamid

Selvarajah

Nuratiqah

et al. 2021

Respirology Case Reports

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Before the era of COVID‐19 pandemic, organizing pneumonia (OP) is often underdiagnosed while tuberculosis (TB) is overdiagnosed especially in an endemic area. We report two patients with cryptogenic OP mimicking TB. First, a 56‐year‐old lady with right upper lobe air space opacity and, second, a 37‐year‐old lady with left upper lobe cavitary lesion. They were treated empirically for pulmonary TB as they had chronic cough with typical chest imaging findings. As there were no improvements despite anti‐TB and investigations for TB were negative, they underwent image‐guided biopsy which confirmed OP. Both patients received 6 months of corticosteroids therapy and made complete recovery. These cases highlight the rare presentation of OP and serves as a reminder that patients tested negative for TB, despite typical history and chest imaging findings, warrant further investigations as many diseases may mimic TB and vice versa.

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TB or Not TB

Cited by 16 publications

References 14 publications

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

Bronchiolitis obliterans organizing pneumonia: Pathogenesis, clinical features, imaging and therapy review

Two cases of cryptogenic organizing pneumonia masquerading as tuberculosis (TB) in a TB endemic area

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