2018
DOI: 10.1021/acs.est.8b00414
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TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways

Abstract: Tetrabromobisphenol A (TBBPA), as well as its alternatives Tetrabromobisphenol S (TBBPS) and Tetrachlorobisphenol A (TCBPA), are widely used halogenated flame retardants. Their high detection rates in human breast milk and umbilical cord serum have raised wide concerns about their adverse effects on human fetal development. In this study, we evaluated the cytotoxicity and neural developmental toxicity of TBBPA, TBBPS, and TCBPA with a mouse embryonic stem cell (mESC) system, at human body fluid and environment… Show more

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Cited by 87 publications
(49 citation statements)
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“…Out of 53 articles, 43 articles included cell viability as the test for neurotoxicity (Reistad et al 2006;Lyng et al 2007;Yoot et al 2007;Costa et al 2007Costa et al , 2016Giordano et al 2008;Le et al 2008;Slotkin et al 2008Slotkin et al , 2017Dingemans et al 2009;Giordano et al 2009;Götz et al 2009; Ndountse and Chan 2009; Rodrigo et al 2009;Fan et al 2010;Tagliaferri et al, 2010;Dishaw et al 2011;Tofighi et al 2011;Chen et al 2011Chen et al , 2017Al-Mousa and Michelangeli 2012;Ziemińska et al 2012;Fanelli et al 2012;Jiang et al 2012;Hendriks et al 2012Hendriks et al , 2014T. Li et al, 2013;Gassmann et al 2014;Ishido and Suzuki 2014;Xu et al 2014;Wu et al 2014Wu et al , 2016Yin et al 2015Yin et al , 2018bYin et al , 2018aSzychowski and Wójtowicz 2016;Hirsch et al 2017;Li et al 2017;Canzoniero et al 2017;Cho et al 2018;Sirenko et al 2019;Wójtowicz et al 2019).…”
Section: Translational In Vitromentioning
confidence: 99%
“…Out of 53 articles, 43 articles included cell viability as the test for neurotoxicity (Reistad et al 2006;Lyng et al 2007;Yoot et al 2007;Costa et al 2007Costa et al , 2016Giordano et al 2008;Le et al 2008;Slotkin et al 2008Slotkin et al , 2017Dingemans et al 2009;Giordano et al 2009;Götz et al 2009; Ndountse and Chan 2009; Rodrigo et al 2009;Fan et al 2010;Tagliaferri et al, 2010;Dishaw et al 2011;Tofighi et al 2011;Chen et al 2011Chen et al , 2017Al-Mousa and Michelangeli 2012;Ziemińska et al 2012;Fanelli et al 2012;Jiang et al 2012;Hendriks et al 2012Hendriks et al , 2014T. Li et al, 2013;Gassmann et al 2014;Ishido and Suzuki 2014;Xu et al 2014;Wu et al 2014Wu et al , 2016Yin et al 2015Yin et al , 2018bYin et al , 2018aSzychowski and Wójtowicz 2016;Hirsch et al 2017;Li et al 2017;Canzoniero et al 2017;Cho et al 2018;Sirenko et al 2019;Wójtowicz et al 2019).…”
Section: Translational In Vitromentioning
confidence: 99%
“…Nowadays, in vitro toxicology, which is based on tissue culture techniques, has been slowly gaining ground as an alternative to animal assays. Although many different kinds of cells have been employed in toxicology, stem cells are the most promising tools, in particular for developmental toxicity investigations (Faiola et al, 2015;Genschow et al, 2002;Liu et al, 2017;Yao et al, 2016;Yin et al, 2018c;Yin et al, 2018b;Yin et al, 2018a).…”
Section: Discussionmentioning
confidence: 99%
“…All the previous developmental neurotoxicity studies were based on live animal assays and may have missed some important toxicity information in the earliest stages of embryonic development. The recently established stem cell toxicology models (Faiola et al, ; Genschow et al, ; Liu et al, ; Yao et al, ; Yin et al, ; Yin et al, ; Yin et al, ) may help solve these issues effectively. In fact, stem cell differentiation can mimic in vitro the developmental process and allow the accumulation of toxicity data at many time points in a time‐efficient and cost‐efficient way.…”
Section: Introductionmentioning
confidence: 99%
“…Tetrabromobisphenol A (TBBPA), a persistent compound synthesized by bromination of BPA initially replaced polybrominated diphenylthers, at present is the most widely employed brominated flame retardant, with a reported 2011 volume of 120 million pounds in the United States [43]. In the last years, tetrabromobisphenol S (TBBPS) and tetrachlorobisphenol A (TCBPA) have been extensively used as alternatives to TBBPA [44]. TBBPA is measured in the environment and in human body [45], and TBBPA exposure represents a significant health risk especially for children residing in an e-waste processing region [46] (Table 1c).…”
Section: Bisphenols In the Environment And Humansmentioning
confidence: 99%