TBG-Dependency of Age Related Variations of Thyroxine and Triiodothyronine

Hesch, R. D.; Gatz, Jennifer; Jüppner, H.; Stubbe, P

doi:10.1055/s-0028-1093563

Cited by 54 publications

(23 citation statements)

References 2 publications

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“…Um estudo com idosos internados demonstrou que os níveis de FT4 diminuem com a idade, mas aumentam proporcionalmente com a gravidade da doença (41). Com relação aos níveis séricos de T3, vários estudos demonstraram uma diminuição progressiva com a idade (9,18,19,23,25,26), chegando a 5,1ng/dl por década (25), embora o T3 reverso não tenha mostrado a mesma tendência (23,26). Por outro lado, outros trabalhos não confirmaram esta tendência na queda do T3 em função da idade (14,24,27).…”

Section: Nívei Dos Hormônios Tiroideanos Tsh E Tbgunclassified

“…Para a TBG, o envelhecimento poderia levar a aumento (19), diminuição (47) ou nenhuma alteração (23), como foi descrito em alguns estudos.…”

Section: Nívei Dos Hormônios Tiroideanos Tsh E Tbgunclassified

“…Alguns autores concordam que, com a idade, ocorra uma diminuição dos níveis séricos de T3, T4 e FT4 (9,14,(18)(19)(20)(21)(22)(23)25,26), enquanto para outros estes se mantém inalterados (14,23,24,27) com o envelhecimento. Níveis elevados (4,8,14) de TSH, baixos (15)(16)(17) ou inalterados (18) já foram descritos na população idosa.…”

Section: Introductionunclassified

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Estudo da Função Tiroideana em Uma População com Mais de 50 Anos

Mendonça

Jorge

2002

Arq Bras Endocrinol Metab

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RESUMOCom objetivo de analisar a freqüência de disfunção tiroideana e de identificar possíveis alterações hormonais decorrentes do envelhecimento, estudamos 198 indivíduos com idade variando de 50 a 85 anos e 106 filhos com idade entre 11 e 49 anos. A prevalência de disfunção tiroideana foi semelhante em ambos grupos (12,6% no grupo de estudo e 14,1% entre os filhos). A presença de um ou dois anticorpos antitiroideanos positivos foi também semelhante entre os grupos (9,1% e 12,3% para os idosos e filhos respectivamente), embora sem correlação disfunção tiroideana. nos idosos. Os níveis séricos de T3 e FT4 foram significantemente menores entre os indivíduos mais velhos quando comparados com os filhos (1,27±0,27 x 1,39±0,31 ng/ml e 0,97±0,29 x 1,18±0,76 ng/dl, respectivamente). Não houve diferença entre os grupos quanto aos níveis de TSH, T4 total e TBG. Concluímos que a prevalência de disfunção tiroideana não foi diferente entre os grupos e que a presença de anticorpos antitiroideanos esteve associada com disfunção da tiróide apenas nos indivíduos mais jovens. A correlação inversa dos níveis de T3 e FT4 com a idade pode refletir uma adaptação à menor necessidade dos hormônios com o envelhecimento. ABSTRACT Thyroid Function Studies in a Population Sample Over 50 Years of Age.We evaluated 198 subjects between 50 and 85 years of age (older group) and 106 individuals of their offspring in the age group 11-49 years (younger group) in order to determine the frequency of thyroid dysfunction and also identify possible hormonal changes due to aging. The prevalence of thyroid dysfunction was similar in both groups (12.6% in the older and 14.1% in the younger groups). The positivity to one or two antithyroid antibodies was also similar between the groups (9.1% and 12.3% for the elderly and the young, respectively), although no correlation with the thyroid dysfunction was found in the elderly. Serum T3 and FT4 levels were significantly lower in the older as compared with the younger subjects (1.27±0.27 vs 1.39±0,31 ng/mL and 0.97±0.29 vs 1.18±0.76 ng/dL, respectively). No statistical significant difference was found between the groups regarding TSH, total T4 and TBG levels. We conclude that the prevalence of thyroid dysfunction was similar between the groups and that the positivity to anti-thyroid antibodies was associated with thyroid dysfunction only in the younger subjects. The inverse correlation between T3 and FT4 levels and the age can reflect an adaptation to the lowest requirements for the hormones with the aging.

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Section: Nívei Dos Hormônios Tiroideanos Tsh E Tbgunclassified

“…Para a TBG, o envelhecimento poderia levar a aumento (19), diminuição (47) ou nenhuma alteração (23), como foi descrito em alguns estudos.…”

Section: Nívei Dos Hormônios Tiroideanos Tsh E Tbgunclassified

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Estudo da Função Tiroideana em Uma População com Mais de 50 Anos

Mendonça

Jorge

2002

Arq Bras Endocrinol Metab

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“…Die radioimmunchemische zu einer Unsicherheit gegenüber der TBG-BestimBestimmung von TBG hat in den letzten Jahren im-mung geführt. Wir haben daher TBG erneut hochgemer mehr zu einer wertvollen Bereicherung in der reinigt und chemisch charakterisiert, worüber an anSchilddrüsendiagnostik selbst beigetragen (3,(8)(9)(10)(11)(12)(13)(14)(15)(16). derer Stelle berichtet wird.…”

Section: Einführungunclassified

Methodische und klinische Evaluation einer neuen enzymimmunologischen Methode zur Bestimmung des Thyroxin bindenden Globulins (TBG) und des T4/TBG-Quotienten: Eine multizentrische Studie

Kessler¹,

Rudorff²,

Oellerich³

et al. 1985

Clinical Chemistry and Laboratory Medicine

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Melhodological and clinical evaluation ofa new enzyme immunological methodfor the determinaüon ofthyroxine binding globulin (TBG) and the T^TBG ratioSummary: A heterogeneous enzyme immunoassay for the determination of thyroxine binding globulin (TBG) was developed and assessed in clinical trials in 12 laboratories. The assay is based on the competition principle and employs plastic tubes coated with goat anti-TBG. CV's between 1.4-8.9% for intra-assay precision and 2.9 -8.6% for inter-assay precision were found over the concentration ränge of 4-40 mg/1 TBG. In comparative studies using highly purified TBG äs Standard, values with Enzymun-Test® TBG were found to be on average 30% lower than those obtained by various TBG-RIAs. A broad-base study, to determine reference values, was carried out on a group of control persons 18 to 50 years old without previous history of thyroid disease. This study revealed a median of 14.33 mg/1 TBG, with 95% of all values between 9.6 and 18.5 mg/1 TBG. The median in wpmen of 14.5 mg/1 TBG was significantly higher than in men (l 3.4 mg/1 TBG). TBG values in hyperthyroid patients were within the reference ränge while those in hypothyroid individuals were elevated. Highly elevated TBG values were seen in women receiving oestrogen (median: 22.2 mg/1 TBG) and in pregnant women (median: 28.5 mg/1 TBG). The T 4 /TBG ratios made it possible to distinguish between euthyroid, hyperthyroid and hypothyroic subjects (median: 4.9, 11.3 and 1.0, respectively). These ratios were significantly lower in pregnant women (median: 3.1) than in the control persons. EinführungThyroxin bindende Globulin (T 4 /TBG)-Verhältnis kann die Fraktion des freien T 4 errechnet werden Das Thyroxin bindende Globulin (TBG) ist das (14). Wir sehen in der getrennten Bestimmung von Transportprotein für lodthyronine mit der höchsten zwei kenngrößenabhängigen Größen einen großen Affinität (l). Seine Aminosäurenzusammensetzung ist klinischen Vorteil gegenüber der direkten Bestimbekannt, obwohl sie in unterschiedlichen Arbeiten mung von freiem T 4 . Die Problematik der TBGverschieden angegeben wird (2, 3). Seine Aminosäure-Bestimmung liegt in ihrer bisher mangelnden Startsequenz ist nur teilweise aufgeklärt, da genügende dardisierung. Aus Mangel an genügend hochreinem, Mengen an hochreinem TBG für solche Analysen chemisch gut charakterisierten TBG liegt keine ehl·-bislang nicht vorlagen (4). Trotz dieses Mangels ist heitliche Referenzpräparation und damit kein gültiger die physiko-chemische Funktion von TBG hinrei-Referenzbereich vor. Dies hat vor allem in der Klinik chend untersucht (1-7). Die radioimmunchemische zu einer Unsicherheit gegenüber der TBG-BestimBestimmung von TBG hat in den letzten Jahren im-mung geführt. Wir haben daher TBG erneut hochgemer mehr zu einer wertvollen Bereicherung in der reinigt und chemisch charakterisiert, worüber an anSchilddrüsendiagnostik selbst beigetragen (3,(8)(9)(10)(11)(12)(13)(14)(15)(16). derer Stelle berichtet wird. Mit dem so gewonnenen Dies gilt vor allem auch für extrathyreoidale ...

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“…Normal aging in men is accompanied by a decline in testicu lar function with decrease of serum testoster one levels [4][5][6] and an increase of LH and FSH levels [5][6][7][8], although there is increasing evidence of a secondary failure of the hypo thalamic-pituitary axis [9], Most studies have shown that serum T3 decreases with age [ 10,11], although an effect of disease and not age itself on serum T3 was also suggested [12]. Serum T4 levels are either unaffected [10,11] or slightly diminished [13,14] and serum TSH levels are elevated in some relatively healthy persons over the age of 60 [11], Although hormonal changes in pa tients with severely uncontrolled, insulin-de pendent diabetes mellitus aged between 17 and 50 years have been reported [15], the changes of serum hormone levels in elderly patients with non-insulin-dependent diabetes mellitus (NIDDM) have not been clearly elu cidated. This study was undertaken to assess the influence of NIDDM on hormonal changes in elderly men.…”

Section: Introductionmentioning

confidence: 99%

Hormonal Changes in Elderly Men with Non-Insulin-Dependent Diabetes mellitus and the Hormonal Relationships to Abdominal Adiposity

1994

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To elucidate the hormonal changes in elderly men with non-insulin-dependent diabetes mellitus (NIDDM) and the hormonal relationship to abdominal adiposity, we measured serum insulin-like growth factor 1 (IGF-1), T₃, T₄, TSH, testosterone, LH, and FSH levels, body mass index (BMI), skinfold thickness and waist-to-hip circumference ratio (W/H) in 40 elderly men (aged over 60 years), 20 elderly men with NIDDM (aged over 60 years) and 30 men aged 21-40 years (controls). The results showed that elderly men with and without NIDDM had lower serum T₃, testosterone and IGF-1 levels and higher serum LH and FSH levels compared with controls. Elderly men with NIDDM had even lower serum testosterone levels compared with elderly men without NIDDM. Elderly men had a higher W/H ratio compared with controls. Elderly men with NIDDM had a higher W/H ratio, BMI and skinfold thickness than elderly men without NIDDM. Age was positively correlated with the W/H ratio. Serum LH and FSH levels were positively correlated with the W/H ratio, and serum IGF-1, T3 and testosterone levels were negatively correlated with W/H ratio. Age, serum IGF-1, T₃, T₄, TSH, LH and FSH levels were not related to BMI or skinfold thickness. Only serum testosterone levels were negatively correlated with BMI or skinfold thickness. In conclusion, elderly men with NIDDM were associated with a marked decrease in serum testosterone levels and an increase of the W/H ratio compared to other groups in addition to the age-associated decrease of serum T₃, IGF-1 and testosterone levels and increase of the W/H ratio and serum LH and FSH levels. W/H ratio, a parameter of abdominal adiposity, was associated with changes of serum hormone levels, including IGF-1, testosterone, LH, FSH and T₃, to a greater degree than BMI or skinfold thickness.

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TBG-Dependency of Age Related Variations of Thyroxine and Triiodothyronine

Cited by 54 publications

References 2 publications

Estudo da Função Tiroideana em Uma População com Mais de 50 Anos

Estudo da Função Tiroideana em Uma População com Mais de 50 Anos

Methodische und klinische Evaluation einer neuen enzymimmunologischen Methode zur Bestimmung des Thyroxin bindenden Globulins (TBG) und des T4/TBG-Quotienten: Eine multizentrische Studie

Hormonal Changes in Elderly Men with Non-Insulin-Dependent Diabetes mellitus and the Hormonal Relationships to Abdominal Adiposity

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