TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway

Jiang, Qiuli; Guan, Yingying; Zheng, Jingmei; Lu, Hua-Dong

doi:10.1002/iid3.796

Cited by 6 publications

(1 citation statement)

References 40 publications

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“…MAZ can also be recruited by G-quadruplexes (G4s) to the promoter of Cyclin D1 (CCND1), forming a MAZ/CCND1-G4 condenser, thereby enhancing the transcription of CCND1 and facilitating the proliferation of Hepatocellular carcinoma cells (HCC) (15). Similar regulatory roles of MAZ have been reported in triple-negative breast cancer (TNBC) and thyroid cancer (THCA) (19)(20). Moreover, MAZ not only directly regulates target gene transcription but also interacts with other TFs.…”

supporting

confidence: 64%

Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma

Zhu,

Feng,

et al. 2024

Preprint

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Myc-associated Zinc-finger Protein (MAZ) has been implicated in the malignant progression of various tumors. However, its expression and functional relationship of MAZ in melanoma have not been previously investigated. This study confirms elevated expression of MAZ in melanoma, correlating with poor patient prognosis. Furthermore, our findings demonstrate that MAZ enhances melanoma progression by promoting proliferation, migration and invasion. It is worth noting that we found that MAZ can target and regulate NDUFS3 transcription to promote melanoma malignant progression. Predictive modeling indicates that the co-expression of MAZ and NDUFS3 could serve as a novel prognostic marker for melanoma patients.

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confidence: 64%

Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma

Zhu,

Feng,

et al. 2024

Preprint

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miR-144-3p Targets GABRB2 to Suppress Thyroid Cancer Progression In Vitro

Xiu,

Deng,

Deng

et al. 2024

Cell Biochem Biophys

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In Silico Insights: QSAR Modeling of TBK1 Kinase Inhibitors for Enhanced Drug Discovery

Ivanov,

Tenchov,

Ralhan

et al. 2024

J. Chem. Inf. Model.

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TBK1, or TANK-binding kinase 1, is an enzyme that functions as a serine/threonine protein kinase. It plays a crucial role in various cellular processes, including the innate immune response to viruses, cell proliferation, apoptosis, autophagy, and antitumor immunity. Dysregulation of TBK1 activity can lead to autoimmune diseases, neurodegenerative disorders, and cancer. Due to its central role in these critical pathways, TBK1 is a significant focus of research for therapeutic drug development. In this paper, we explore data from the CAS Content Collection regarding TBK1 and its implication in a large assortment of diseases and disorders. With the demand for developing efficient TBK1 inhibitors being outlined, we focus on utilizing a machine learning approach for developing predictive models for TBK1 inhibition, derived from the fragment-functional analysis descriptors. Using the extensive CAS Content Collection, we assembled a training set of TBK1 inhibitors with experimentally measured IC50 values. We explored several machine learning techniques combined with various molecular descriptors to derive and select the best TBK1 inhibitor QSAR models. Certain significant structural alerts that potentially contribute to inhibition of TBK1 are outlined and discussed. The merit of the article stems from identifying the most adequate TBK1 QSAR models and subsequent successful development of advanced positive training data to facilitate and enhance drug discovery for an important therapeutic target such as TBK1 inhibitors, based on an extensive, wide-ranging set of scientific information provided by the CAS Content Collection.

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TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway

Cited by 6 publications

References 40 publications

Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma

Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma

miR-144-3p Targets GABRB2 to Suppress Thyroid Cancer Progression In Vitro

In Silico Insights: QSAR Modeling of TBK1 Kinase Inhibitors for Enhanced Drug Discovery

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